The voltage dependent anion channel affects mitochondrial cholesterol distribution and function
Abstract
We have observed abnormally high membrane cholesterol levels and a subsequent deficiency of oxidative energy production in mitochondria from cultured Morris hepatoma cells (MH7777). Using cholesterol affinity chromatography and MALDI-TOF Mass Spectrometry, we have identified the voltage dependent anion channel (VDAC) as a necessary component of a protein complex involved in mitochondrial membrane cholesterol distribution. VDAC is known to associate strongly with hexokinase, particularly in glycolytic cancers. By constructing an E72Q mutant form of VDAC that inhibits its binding of hexokinase, we report an increase in oxidative phosphorylation activity of MH7777 cells, as well as reduced membrane cholesterol ratios to levels near that of normal liver mitochondria. This paper demonstrates that the ability of VDAC to influence mitochondrial membrane cholesterol distribution may have implications on mitochondrial characteristics such as oxidative phosphorylation and induction of apoptosis, as well as the propensity of cancer cells to exhibit a glycolytic phenotype.
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VDAC appears to play a significant, albeit poorly understood, role in cellular cholesterol homeostasis.
“Moreover, VDAC also appears to play a significant, albeit poorly understood, role in cellular cholesterol homeostasis (102).”
From Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies (2016) · cites this paper as [102]
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- Authors
- Campbell, A. M., & Chan, S. H. P.
- Affiliations
- Syracuse University (US)
- Corresponding author
- Campbell, Andrew M.
- Chan, Samuel H.P.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 466
- Issue
- 2
- Pages
- 203-210
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2072887098
- Cited by
- 47
- References
- 54
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 2 · 2017: 7 · 2016: 3 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 4
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Syracuse University Libraries (Syracuse University) (submittedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (CA-20454)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- voltage-dependent anion channel, cholesterol distribution, oxidative phosphorylation, hexokinase, glycolytic phenotype, cancer metabolism, apoptosis, mitochondrial protein complexes
- MeSH terms
- Animals, Cholesterol, Hexokinase, Male, Mitochondria, Liver, Mitochondrial Swelling, Mutation, Oxidative Phosphorylation, Signal Transduction, Rats, Sprague-Dawley, Apoptosis, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Cell Line, Tumor, Voltage-Dependent Anion Channels, Rats, Membrane Potential, Mitochondrial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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