Cited by 229Bone Metabolism and DiseasesNeuropeptides and Animal PhysiologyBone health and osteoporosis research

The DOI matches its Crossref record; 105 of the 106 references it cites were found in a registry or an index.

Regulation of bone remodeling by the central and peripheral nervous system

Open access

Elefteriou, Florent·2008·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2008.03.016PMC PMC2430105

Open this paper in CoChat — free account

Abstract

The homeostatic nature of bone remodeling has become a notion further supported lately by the demonstration that neuropeptides and their receptors regulate osteoblast and osteoclast function in vivo. Following initial studies reporting the presence of nerves and nerve-derived products within the bone microenvironment and the expression of receptors for these neuropeptides in bone cells, new experimental and mechanistic evidence based on in vivo murine genetic and pharmacologic models recently demonstrated that inputs from the central and peripheral nervous system feed into the already complex regulatory machinery controlling bone remodeling. The function of a number of "osteo-neuromediators" has been characterized, including norepinephrine and the beta2-adrenergic receptor, Neuropeptide Y and the Y1 and Y2 receptors, endocannabinoids and the CB1 and CB2 receptors, as well as dopamine, serotonin and their receptors and transporters, Calcitonin gene-related peptide, and neuronal NOS. This new body of evidence suggests that neurons in the central nervous system integrate clues from the internal and external milieux, such as energy homeostasis, glycemia or reproductive signals, with the regulation of bone remodeling. The next major tasks in this new area of bone biology will be to understand, at the molecular level, the mechanisms by which common central neural systems regulate and integrate these major physiological functions, the relative importance of the central and peripheral actions of neuropeptides present in both compartments and their relationship, and how bone cells signal back to central centers, because the definition of a homeostatic function implies the existence of feedback signals. Together, these findings shed a new light on the complexity of the mechanisms regulating bone remodeling and uncovered new potential therapeutic strategies for the design of bone anabolic treatments. This review summarizes the latest advances in this area, focusing on investigations based on in vivo animal studies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.abb.2008.03.016

Cites

105 of 105 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496
Endocrine regulation of energy metabolism by the skeleton
Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554
Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
Amara, S. G., Jonas, V., Rosenfeld, M. G., Ong, E. S., & Evans, R. M. (1982) · Nature · doi:10.1038/298240a0 · Cited by 2,105
Leptin Inhibits Bone Formation through a Hypothalamic Relay
Ducy, P., Amling, M., Takeda, S., Priemel, M., Schilling, A. F., Beil, F. T., Shen, J., Vinson, C., Rueger, J. M., & Karsenty, G. (2000) · Cell · doi:10.1016/s0092-8674(00)81558-5 · Cited by 2,077
Leptin Regulates Bone Formation via the Sympathetic Nervous System
Takeda, S., Elefteriou, F., Levasseur, R., Liu, X., Zhao, L., Parker, K. L., Armstrong, D., Ducy, P., & Karsenty, G. (2002) · Cell · doi:10.1016/s0092-8674(02)01049-8 · Cited by 1,735
Self-citation
Leptin
Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428
Leptin regulation of bone resorption by the sympathetic nervous system and CART
Elefteriou, F., Ahn, J. D., Takeda, S., Starbuck, M., Yang, X., Liu, X., Kondo, H., Richards, W. G., Bannon, T. W., Noda, M., et al. (2005) · Nature · doi:10.1038/nature03398 · Cited by 1,311
Self-citation
Hypothalamic CART is a new anorectic peptide regulated by leptin
Kristensen, P. L., Judge, M. E., Thim, L., Ribel, U., Christjansen, K. N., Wulff, B. S., Clausen, J. T., Jensen, P. B., Madsen, O. D., Vrang, N., et al. (1998) · Nature · doi:10.1038/29993 · Cited by 1,282
ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology
Yang, X., Matsuda, K., Bialek, P., Jacquot, S., Masuoka, H. C., Schinke, T., Li, L., Brancorsini, S., Sassone‐Corsi, P., Townes, T. M., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00344-7 · Cited by 822

Flagged first, then by citations

Show all 106 references

1 of the 106 references couldn’t be matched to a known paper.

Research works printed but not linked: 7

Baldock, 2002, J. Clin. Invest., 109, 915, 10.1172/JCI0214588 · DOI
Orzel, 1985, J. Nucl. Med., 26, 125
Yamada, 2007, Int. J. Mol. Med., 19, 791
Laroche, 1997, Rev. Rhum. Engl. Ed., 64, 106
Chenu, 2002, J. Musculoskelet. Neuronal Interact., 2, 282
Taylor, 2002, J. Musculoskelet. Neuronal Interact., 2, 285
Shih, 1997, Clin. Orthop. Relat. Res., 335

Sorted by citations

Items 101–200 of 228

Osteoporosis in the at-risk asthmatic
Aljubran, S. A., Whelan, G. J., Glaum, M. C., & Lockey, R. F. (2014) · Allergy · doi:10.1111/all.12438 · Cited by 22
Nociceptor mechanisms underlying pain and bone remodeling via orthodontic forces: toward no pain, big gain
Wang, S., Ko, C., & Chung, M. (2024) · Frontiers in Pain Research · doi:10.3389/fpain.2024.1365194 · Cited by 24
Microsurgical Techniques Used to Construct the Vascularized and Neurotized Tissue Engineered Bone
Fan, J., Bi, L., Jin, D., Wei, K.-H., Chen, B., Zhang, Z., & Pei, G. (2014) · BioMed Research International · doi:10.1155/2014/281872 · Cited by 22
Bone loss in MPTP mouse model of Parkinson's disease is triggered by decreased osteoblastogenesis and increased osteoclastogenesis
Ali, S. J., Ellur, G., Khan, M. T., & Sharan, K. (2018) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2018.12.003 · Cited by 22
Effects of propranolol on the development of glucocorticoid-induced osteoporosis in male rats
Folwarczna, J., Pytlik, M., Śliwiński, L., Cegieła, U., Nowińska, B., & Rajda, M. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70620-x · Cited by 22
Changes in the mRNA expression of osteoblast‐related genes in response to β3‐adrenergic agonist in UMR106 cells
Nuntapornsak, A., Wongdee, K., Thongbunchoo, J., Krishnamra, N., & Charoenphandhu, N. (2009) · Cell Biochemistry and Function · doi:10.1002/cbf.1617 · Cited by 22
β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis
Rösch, G., Muschter, D., Taheri, S., Bagdadi, K. E., Dorn, C., Meurer, A., Zaucke, F., Schilling, A. F., Grässel, S., Straub, R. H., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.801505 · Cited by 21
Mechanisms Supporting the Use of Beta-Blockers for the Management of Breast Cancer Bone Metastasis
Madel, M., & Elefteriou, F. (2021) · Cancers · doi:10.3390/cancers13122887 · Cited by 25
Self-citation
Stimulant use and bone health in US children and adolescents: analysis of the NHANES data
Fu, Y., Wang, G., Liu, J., Li, M., Dong, M., Zhang, C., Xu, R., & Liu, X. (2022) · European Journal of Pediatrics · doi:10.1007/s00431-021-04356-w · Cited by 20
Brain-Derived Neurotrophic Factor (BDNF) Enhances Osteogenesis and May Improve Bone Microarchitecture in an Ovariectomized Rat Model
Park, E. J.-J., Truong, V., Jeong, W., & Min, W. (2024) · Cells · doi:10.3390/cells13060518 · Cited by 20
Neuronal regulation of bone and tendon injury repair: a focused review
Xu, M., Zhu, M., Qin, Q., Xing, X., Archer, M., Ramesh, S., Cherief, M., Li, Z., Lévi, B., Clemens, T. L., et al. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae087 · Cited by 20
Low dose of propranolol does not affect rat osteotomy healing and callus strength
Smitham, P. J., Crossfield, L., Hughes, G., Goodship, A. E., Blunn, G. W., & Chenu, C. (2014) · Journal of Orthopaedic Research® · doi:10.1002/jor.22619 · Cited by 19
PTH Regulates β2‐Adrenergic Receptor Expression in Osteoblast‐Like MC3T3‐E1 Cells
Moriya, S., Hayata, T., Notomi, T., C, S. A. A., Nakamaoto, T., Izu, Y., Kawasaki, M., Yamada, T., Shirakawa, J., Kaneko, K., et al. (2014) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24953 · Cited by 19
Chronic Psychosocial Stress Impairs Bone Homeostasis: A Study in the Social Isolation Reared Rat
Schiavone, S., Morgese, M. G., Mhillaj, E., Bové, M., Giorgi, A. D., Cantatore, F. P., Camerino, C., Tucci, P., Maffulli, N., Cuomo, V., et al. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00152 · Cited by 19
Effects of Photoperiod Regime on Meat Quality, Oxidative Stability, and Metabolites of Postmortem Broiler Fillet (M. Pectoralis major) Muscles
Tuell, J. R., Park, J., Wang, W., Cooper, B. R., Sobreira, T. J. P., Cheng, H. W., & Kim, Y. H. B. (2020) · Foods · doi:10.3390/foods9020215 · Cited by 18
The Role of the Nervous System in Hematopoietic Stem Cell Mobilization
Saba, F., Soleimani, M., Atashi, A., Mortaz, E., Shahjahani, M., Roshandel, E., Jaseb, K., & Saki, N. (2013) · Laboratory Hematology · doi:10.1532/lh96.12013 · Cited by 18
Childhood socioeconomic status and adult femoral neck bone strength: Findings from the Midlife in the United States Study
Karlamangla, A. S., Mori, T., Merkin, S. S., Seeman, T. E., Greendale, G. A., Binkley, N., & Crandall, C. J. (2013) · Bone · doi:10.1016/j.bone.2013.06.021 · Cited by 18
CRMP4 Inhibits Bone Formation by Negatively Regulating BMP and RhoA Signaling
Abdallah, B. M., Figeac, F., Larsen, K. H., Ditzel, N., Keshari, P., Isa, A., Jafari, A., Andersen, T. L., Delaissé, J., Goshima, Y., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3069 · Cited by 20
The role of catecholamines in mesenchymal stem cell fate
Hajifathali, A., Saba, F., Atashi, A., Soleimani, M., Mortaz, E., & Rasekhi, M. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1984-8 · Cited by 18
Effects of Sympathetic Innervation Loss on Mandibular Distraction Osteogenesis
Wang, T., Cao, J., Du, Z.-J., Zhang, Y.-B., Liu, Y., Wang, L., & Lei, D. (2012) · Journal of Craniofacial Surgery · doi:10.1097/scs.0b013e31825daab2 · Cited by 18
A novel specialized staging system for cancellous fracture healing, distinct from traditional healing pattern of diaphysis corticalfracture?
Han, D., Han, N., Xue, F., & Zhang, P. (2015) · PubMed Central · Cited by 18
Femoral bone mineral density and bone mineral content in bromocriptine-treated pregnant and lactating rats
Suntornsaratoon, P., Wongdee, K., Krishnamra, N., & Charoenphandhu, N. (2009) · The Journal of Physiological Sciences · doi:10.1007/s12576-009-0059-1 · Cited by 17
Single-cell sequencing uncovers sensory neuron–mediated CGRP signaling as a driver of sarcoma progression
Ramesh, S., Qin, Q., Li, Z., Cherief, M., Zhong, L., Archer, M., Xing, X., Thottappillil, N., Balaji, D., Bae, S. S., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2500161122 · Cited by 18
Osteoporosis: From Bone Biology to Individual Treatment Decision
Gonçalves, M. J., Rodrigues, A. M., Canhão, H. M., & Fonseca, J. E. (2013) · Acta Médica Portuguesa · doi:10.20344/amp.4271 · Cited by 16
Endobiogeny: A Global Approach to Systems Biology (Part 2 of 2)
Lapraz, J.-C., Hedayat, K. M., & Pauly, P. (2013) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2013.013 · Cited by 17
Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing
Nazzal, M. K., Morris, A. J., Parker, R. S., White, F. A., Natoli, R. M., Kacena, M. A., & Fehrenbacher, J. C. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-023-00850-2 · Cited by 15
The role of exercise in enhancing brain and cerebrovascular health via the bone–brain axis: implications for surgical and clinical interventions
Shi, H., Huang, L., Wang, Q., Zhang, N., Lv, C., Lin, C., Shao, L., Xia, D., Zhao, Z., Yang, G., et al. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003030 · Cited by 15
Skeletal integration of energy homeostasis: Translational implications
Lecka‐Czernik, B., & Rosen, C. J. (2015) · Bone · doi:10.1016/j.bone.2015.07.026 · Cited by 14
Low-intensity pulsed ultrasound improves osseointegration of dental implant in mice by inducing local neuronal production of αCGRP
Jiang, Y., Yuan, Y., Xiong, Y., Wang, B., Guo, Y., Gong, P., & Zhang, L. (2020) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2020.104736 · Cited by 14
Selective serotonin reuptake inhibitors (SSRI) affect murine bone lineage cells
Durham, E. L., Zhang, Y., LaRue, A. C., Bradshaw, A. D., & Cray, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117827 · Cited by 13
Characterization of a composite injury model of severe lower limb bone and nerve trauma
Uhrig, B. A., Clements, I. P., Boerckel, J. D., Huebsch, N., Bellamkonda, R. V., & Guldberg, R. E. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1537 · Cited by 13
Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease
Contreras, M. A., Ries, W. L., Shanmugarajan, S., Arboleda, G., Singh, I., & Singh, A. K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.04.006 · Cited by 13
Elucidating the Mechanism(s) Underlying Antipsychotic- and Antidepressant-Mediated Fractures
Houseknecht, K. L. (2017) · JOURNAL OF MENTAL HEALTH AND CLINICAL PSYCHOLOGY · doi:10.29245/2578-2959/2018/1.1106 · Cited by 13
Dopamine Suppresses Osteogenic Differentiation of Rat Bone Marrow-Derived Mesenchymal Stem Cells via AKT/GSK-3β/β-Catenin Signaling Pathway
Kuang, Z., Chen, Z., Tu, S., Mai, Z., Chen, L., Kang, X., Chen, X., Wei, J., Wang, Y., Peng, Y. W., et al. (2022) · Stem Cells International · doi:10.1155/2022/4154440 · Cited by 13
Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish
Suárez‐Bregua, P., Saxena, A., Bronner-Fraser, M. E., & Rotllant, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186444 · Cited by 12
Expression of circulating Semaphorin3A and its association with inflammation and bone destruction in rheumatoid arthritis
Gao, H., Ma, X., Guo, Q., Xie, L., Zhong, Y., & Zhang, X. (2018) · Clinical Rheumatology · doi:10.1007/s10067-018-4070-x · Cited by 12
Loss of inhibition over master pathways of bone mass regulation results in osteosclerotic bone metastases in prostate cancer
Rentsch, C. A., Cecchini, M. G., & Thalmann, G. N. (2009) · Swiss Medical Weekly · doi:10.4414/smw.2009.12284 · Cited by 12
Unraveling the Bone–Brain Communication Network
Hansda, S., & Das, H. (2025) · Biology · doi:10.3390/biology14091279 · Cited by 13
Osteolytic cancer cells induce vascular/axon guidance processes in the bone/bone marrow stroma
Hensel, J., Wetterwald, A., Temanni, R., Keller, I., Riether, C., van der Pluijm, G., Cecchini, M. G., & Thalmann, G. N. (2018) · Oncotarget · doi:10.18632/oncotarget.25608 · Cited by 11
Small Vessel Disease/White Matter Disease of the Brain and Its Association With Osteoporosis
Alagiakrishnan, K., Hsueh, J., Zhang, E. M., Khan, K. A., & Senthilselvan, A. (2015) · Journal of Clinical Medicine Research · doi:10.14740/jocmr2119w · Cited by 11
Bone Balance within a Cortical BMU: Local Controls of Bone Resorption and Formation
Smith, D. W., Gardiner, B. S., & Dunstan, C. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040268 · Cited by 12
Biology of Bone and Cartilage
Boyce, B. F., Zuscik, M. J., & Xing, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804182-6.00011-3 · Cited by 14
The Effect of Sensory Innervation on the Inorganic Component of Bones and Teeth; Experimental Denervation – Review
Němec, I., Smrčka, V., & Pokorny, J. (2018) · Prague Medical Report · doi:10.14712/23362936.2019.1 · Cited by 10
Association between cerebral atrophy and osteoporotic vertebral compression fractures
Bae, I.-S., Kim, J. M., Cheong, J. H., Han, M., & Ryu, J. I. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224439 · Cited by 10
PQBP1, an intellectual disability causative gene, affects bone development and growth
Yang, S.-S., Ishida, T., Fujita, K., Nakai, Y., Ono, T., & Okazawa, H. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.12.097 · Cited by 10
Pharmacological tools to mobilise mesenchymal stromal cells into the blood promote bone formation after surgery
Fellous, T. G., Redpath, A. N., Fleischer, M. M., Gandhi, S. D., Hartner, S. E., Newton, M. D., François, M., Wong, S., Gowers, K. H. C., Fahs, A. M., et al. (2020) · npj Regenerative Medicine · doi:10.1038/s41536-020-0088-1 · Cited by 10
Effect of Substance P in Mandibular Osteotomies After Amputation of the Inferior Alveolar Nerve
He, H., Tan, Y., & Yang, M. (2010) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.joms.2010.02.016 · Cited by 10
Improved bone status by the β-blocker propranolol in an animal model of nutritional growth retardation
Lezón, C. E., Olivera, M. I., Bozzini, C., Mandalunis, P., Alippi, R. M., & Boyer, P. M. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450811145x · Cited by 10
Central adiponectin induces trabecular bone mass partly through epigenetic downregulation of cannabinoid receptor CB1
Jiang, H., Wu, Y., Valverde, P., Murray, D., Tang, J. H., Yao, Q., Han, Q., Zhang, J., Zhang, L., Sui, L., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27460 · Cited by 9
Pulsed Focused Ultrasound Treatment of Muscle Mitigates Paralysis-Induced Bone Loss in the Adjacent Bone: A Study in a Mouse Model
Poliachik, S. L., Khokhlova, T. D., Wang, Y.-N., Simon, J. C., & Bailey, M. R. (2014) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2014.02.027 · Cited by 9
A computational study of the dual effect of intermittent and continuous administration of parathyroid hormone on bone remodeling
Zhao, Y., & Zhang, G. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.007 · Cited by 9
Stem Cells in Bone Repair and Regeneration
Berika, M. Y., & El-Hashash, A. H. K. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220410215357 · Cited by 8
Mechanical mandible competence in rats with nutritional growth retardation
Lezón, C. E., Pintos, P. M., Bozzini, C., Romero, A. A., Casavalle, P. L., Friedman, S., & Boyer, P. M. (2017) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2017.03.009 · Cited by 8
Bone loss in adult offspring induced by low-dose exposure to teratogens
Torchinsky, A. M., Mizrahi, L., Savion, S., Shahar, R., Toder, V., & Kobyliansky, E. (2011) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-011-0311-7 · Cited by 8
Peripartal alterations of calcitonin gene‐related peptide and minerals in dairy cows affected by milk fever
Zebeli, Q., Beitz, D. C., Bradford, B. J., Dunn, S. M., & Ametaj, B. N. (2013) · Veterinary Clinical Pathology · doi:10.1111/vcp.12022 · Cited by 8
The Unknown Process Osseointegration
López-Valverde, N., Fraile, J. F., & López‐Valverde, A. (2020) · Biology · doi:10.3390/biology9070168 · Cited by 8
Neural regulation of bone: from central neural circuits to peripheral innervation of the skeletal stem cell niche
Chen, Z., Luo, Z., Greenblatt, M. B., Wu, Z., & Xu, R. (2026) · Bone Research · doi:10.1038/s41413-026-00534-4 · Cited by 9
The short-term effects of CGRP monoclonal antibodies on bone turnover: A prospective cohort study
Ray, J. C., Sztal‐Mazer, S., Baker, J., Matharu, M. S., & Hutton, E. J. (2023) · Cephalalgia · doi:10.1177/03331024231180562 · Cited by 7
Adult bone strength of children from single-parent families: the Midlife in the United States Study
Crandall, C. J., Karlamangla, A. S., Merkin, S. S., Binkley, N., Carr, D., Greendale, G. A., & Seeman, T. E. (2014) · Osteoporosis International · doi:10.1007/s00198-014-2990-0 · Cited by 7
Effects of Ultra-early Hyperbaric Oxygen Therapy on Femoral Calcitonin Gene-Related Peptide and Bone Metabolism of Rats With Complete Spinal Transection
Liu, M., Chen, H., Tong, M., Zhou, J., & Wu, X. (2018) · Spine · doi:10.1097/brs.0000000000002581 · Cited by 7
Biology of Bone and Cartilage
Boyce, B. F., Zuscik, M. J., & Xing, L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-387829-8.00001-9 · Cited by 8
Osteoclast activity sculpts craniofacial form to permit sensorineural patterning in the zebrafish skull
Miao, K., Cozzone, A., Caetano‐Lopes, J., Harris, M. P., & Fisher, S. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.969481 · Cited by 6
Nociceptors regulate osteoimmune transcriptomic response to infection
Lillis, K. V., Austah, O. N., Grinceviciute, R., Garlet, G. P., & Diogenes, A. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-44648-9 · Cited by 6
Fenoterol did not enhance glucocorticoid-induced skeletal changes in male rats.
Folwarczna, J., Nowińska, B., Śliwiński, L., Pytlik, M., Cegieła, U., & Betka, A. (2011) · Acta Biochimica Polonica · doi:10.18388/abp.2011_2241 · Cited by 6
A new approach to biological modeling: Introduction to the biology of functions
Hedayat, K. M., & Lapraz, J.-C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816903-2.00015-x · Cited by 5
Absence of positive effect of black cohosh (Cimicifuga racemosa) on fracture healing in osteopenic rodent model
Kolios, L., Daub, F., Sehmisch, S., Frosch, K., Tezval, M., Stürmer, K. M., Wuttke, W., & Stuermer, E. K. (2010) · Phytotherapy Research · doi:10.1002/ptr.3176 · Cited by 5
Bone biomechanical properties and tissue-scale bone quality in a genetic mouse model of familial dysautonomia
Vahidi, G., Flook, H., Sherk, V. D., Mergy, M. A., Lefcort, F. B., & Heveran, C. M. (2021) · Osteoporosis International · doi:10.1007/s00198-021-06006-1 · Cited by 5
Osteoporosis and diabetes mellitus: a modern viewpoint
Molitvoslovova, N. A., & Galstyan, G. R. (2013) · Diabetes Mellitus · doi:10.14341/2072-0351-3598 · Cited by 5
The Bone Biology and the Nanotechnology for Bone Engineering and Bone Diseases
Mitri, F. F., & Ingle, A. P. (2020) · Springer eBooks · doi:10.1007/978-3-030-35147-2_13 · Cited by 5
Effects of 180-day's Isolation on Bone, Glycolipid Metabolism and Their Correlation Analysis
Yang, C., Xu, Z., Li, K., ZHANG, H., Wang, H., Wu, F. Y., Xu, Z., Dai, Z., & Li, Y. (2021) · Chinese Journal of Space Science · doi:10.11728/cjss2021.02.293 · Cited by 4
Induced pluripotent stem cell-derived neural stem cells promote bone formation in mice with calvarial defects
Shiwaku, Y., Okawa, H., Suzuki, I., Sakai, S., Egusa, H., & Suzuki, O. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.08.054 · Cited by 4
Effect of rat brain tissue extracts on osteoblast proliferation and differentiation
Huang, G., Ma, X., Xia, X., Jiang, J., Wei-fang, J., Gao, J.-J., & Huang-yuan, H. (2011) · International Orthopaedics · doi:10.1007/s00264-011-1423-3 · Cited by 4
Do effects of propranolol on the skeletal system depend on the estrogen status?
Śliwiński, L., Folwarczna, J., Pytlik, M., Cegieła, U., Nowińska, B., Trzeciak, H., & Trzeciak, H. I. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71493-2 · Cited by 4
Endocrinology of bone/brain crosstalk
Metozzi, A., Bonamassa, L., Brandi, G., & Brandi, M. L. (2015) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2015.979787 · Cited by 4
Performance of Schwann cell transplantation into extracted socket after inferior alveolar nerve injury in a novel rat model
Ito, T., Toriumi, T., Otake, K., Okuwa, Y., Tanaka, S., Arai, Y., Kurita, K., & Honda, M. J. (2020) · Journal of Oral Science · doi:10.2334/josnusd.19-0487 · Cited by 4
Effects of highly selective sensory/motor nerve injury on bone metabolism and bone remodeling in rats.
Yang, Y., Zhou, J., Liang, C., Xiao, Q., Chen, Y., & Yu, B. (2022) · PubMed Central · Cited by 4
Nitric Oxide Signaling and Nitrosative Stress in the Musculoskeletal System
Rőszer, T. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_1 · Cited by 4
Depression, selective serotonin re-uptake inhibitors and the regulation of bone mass
Bab, I., & Yirmiya, R. (2009) · IBMS BoneKEy · doi:10.1138/20090357 · Cited by 3
Role of PQBP1 in Pathogen Recognition—Impact on Innate Immunity
Wiench, L., Rizzo, D., Sinay, Z., Nacsa, Z., Fuchs, N. V., & König, R. (2024) · Viruses · doi:10.3390/v16081340 · Cited by 3
Neural Modulation of Orthodontic Tooth Movement
John, K., Robert, M., Dolce, C., Edgardo, J., Bokrand-Donatelli, Y., & Shannon, L. (2011) · InTech eBooks · doi:10.5772/20800 · Cited by 3
Catgut embedding in acupoints combined with repetitive transcranial magnetic stimulation for the treatment of postmenopausal osteoporosis: study protocol for a randomized clinical trial
Qiu, J., Xu, J., Cai, Y., Li, M., Peng, Y., Xu, Y., & Chen, G. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1295429 · Cited by 3
Bone and Energy Metabolism
Rosen, C. J. (2017) · Molecular and integrative toxicology · doi:10.1007/978-3-319-56192-9_15 · Cited by 3
Sensory neurons sprouting is dependent on osteoclast-derived extracellular vesicles involving the activation of epidermal growth factor receptorsPreprint
Neto, E., Leitão, L., Mateus, J. C., Sousa, D. M., Conceição, F., Alves, C. J., Oreffo, R. O. C., West, J. J., Aguiar, P., & Lamghari, M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/259218 · Cited by 3
Cutting edge research on stem cell applications in joint, cartilage, and bone repair and regeneration
Yuan, D., & El-Hashash, A. H. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91938-8.00007-x · Cited by 3
Physiopathologie de l’ostéoporose d’immobilisation
Alexandre, C., & Vico, L. (2011) · Revue du Rhumatisme · doi:10.1016/j.rhum.2011.03.004 · Cited by 2
Effect of inferior alveolar nerve transection on the inorganic component of bone of rat mandible.
Němec, I., Smrčka, V., Mihaljevič, M., Hill, M., & Pokorny, J. (2020) · PubMed Central · Cited by 2
Models of composite bone and soft-tissue limb trauma
Uhrig, B. A., Li, M.-T. A., Willett, N. J., & Guldberg, R. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9780511997839.035 · Cited by 2
More on bone and nerves
de Vernejoul, M. C. (2013) · IBMS BoneKEy · doi:10.1038/bonekey.2013.47 · Cited by 2
Rise of the Animal Kingdom and Epigenetic Mechanisms of Evolution
Cabej, N. R. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-401667-5.00005-5 · Cited by 3
Bone and Nerve Response to Sciatic Compression Neuropathy in a Rabbit Model
Fringuello, A. R., Kurtzman, J. S., Hayes, W. T., Carter, J., & Koehler, S. M. (2025) · Journal of Orthopaedic Research® · doi:10.1002/jor.26045 · Cited by 1
Association between timing of surgery and refracture after initial osteoporotic fractures
Xu, Z., Wang, P., Qiu, Y., & Liu, Y. C. (2025) · Scientific Reports · doi:10.1038/s41598-025-04672-3 · Cited by 1
Recent advances in human milk bioactives: osteopontin
Chang, S., Lien, C.-H., & Yeung, C. (2025) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2025.08.006 · Cited by 1
Cannabinoids: new friends in bone fracture and in joint disease prevention?
Palmini, G., Marini, F., Giusti, F., Donati, S., Aurilia, C., Falsetti, I., Zonefrati, R., Galli, G., Iantomasi, T., & Brandi, M. L. (2022) · International Journal of Bone Fragility · doi:10.57582/ijbf.220203.084 · Cited by 1
Pathogenesis and Neuroendocrine Immunology
Straub, R. H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-803321-0.00002-1 · Cited by 1
Nitric Oxide Signaling and Nitrosative Stress in the Musculoskeletal System 128
szer, T. R. ̋. (2014) · Cited by 1
"The Place of Osteoimmunology in the Pathogenesis of Rheumatic Joint and Bone Diseases"
Momcheva, I. I. (2023) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2023.50.007894
Bone Markers in Charcot NeuroarthropathyPreprint
Patel, K., Bernstein, B., Grahn, B., & Stoltzfus, J. C. (2020) · doi:10.21203/rs.3.rs-29888/v1 · Cited by 1
Reduced order modelling of bone resorption and formation.
Moroz, A. (2011) · DMU Open Research Archive (De Montfort University) · Cited by 1
Nervous System Diseases, Disorders, and Bone: Emerging Therapeutics and Treatment Options
Barbe, M. F., & Popoff, S. N. (2012) · Springer eBooks · doi:10.1007/978-1-4471-2745-1_17
Non-autonomous regulation of bone mass accrual and the role of T-cell protein tyrosine phosphatase in the bone regulation of insulin sensitivity
Zee, T. (2013) · doi:10.7916/d8f47w70

Authors: Elefteriou, F.
Affiliations: Vanderbilt University (US)
Corresponding author: Elefteriou, Florent
ORCID: Elefteriou, Florent
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2008-05
Volume: 473
Issue: 2
Pages: 231-236
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2008.03.016
PMC: PMC2430105
OpenAlex: W1963686806
Cited by: 229
References: 106
Citations by year: 2026: 9 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 8 · 2021: 9 · 2020: 17 · 2019: 14 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 13 · 2014: 27 · 2013: 17 · 2012: 16
FWCI: 1.16
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Vanderbilt University
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK058883, R21DK074994)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: bone remodeling, bone homeostasis, neuropeptides, norepinephrine, beta2-adrenergic receptor, neuropeptide Y, Y1 receptor, Y2 receptor, endocannabinoids, CB1 receptor, CB2 receptor, dopamine, serotonin, calcitonin gene-related peptide, neuronal nitric oxide synthase, osteoblasts, osteoclasts, central nervous system, peripheral nervous system, bone microenvironment, energy homeostasis, bone anabolic therapy
MeSH terms: Animals, Brain, Calcitonin, Humans, Hypothalamus, Neurons, Neuropeptide Y, Osteoblasts, Bone Remodeling, Receptors, Neuropeptide Y, Peripheral Nervous System

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Regulation of bone remodeling by the central and peripheral nervous system

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks