Cited by 1,844Bone Metabolism and DiseasesBone health and osteoporosis researchBone and Dental Protein Studies

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Functions of RANKL/RANK/OPG in bone modeling and remodeling

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Boyce, Brendan F., Xing, Lianping·2008·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2008.03.018PMC PMC2413418

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Abstract

The discovery of the RANKL/RANK/OPG system in the mid 1990s for the regulation of bone resorption has led to major advances in our understanding of how bone modeling and remodeling are regulated. It had been known for many years before this discovery that osteoblastic stromal cells regulated osteoclast formation, but it had not been anticipated that they would do this through expression of members of the TNF superfamily: receptor activator of NF-kappaB ligand (RANKL) and osteoprotegerin (OPG), or that these cytokines and signaling through receptor activator of NF-kappaB (RANK) would have extensive functions beyond regulation of bone remodeling. RANKL/RANK signaling regulates osteoclast formation, activation and survival in normal bone modeling and remodeling and in a variety of pathologic conditions characterized by increased bone turnover. OPG protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. Thus, the relative concentration of RANKL and OPG in bone is a major determinant of bone mass and strength. Here, we review our current understanding of the role of the RANKL/RANK/OPG system in bone modeling and remodeling.

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Authors: Boyce, B. F., & Xing, L.
Affiliations: University of Rochester Medicine (US)
Corresponding author: Boyce, Brendan F.
ORCID: Boyce, Brendan F.
Xing, Lianping
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2008-05
Volume: 473
Issue: 2
Pages: 139-146
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2008.03.018
PMC: PMC2413418
OpenAlex: W1975953388
Cited by: 1,844
References: 107
Citations by year: 2026: 107 · 2025: 132 · 2024: 149 · 2023: 127 · 2022: 145 · 2021: 166 · 2020: 141 · 2019: 122 · 2018: 94 · 2017: 106 · 2016: 71 · 2015: 92 · 2014: 76 · 2013: 73 · 2012: 69
FWCI: 4.48
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (R21AR049305, R01AR043510)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords: RANK/RANKL/OPG system, bone remodeling, bone modeling, osteoclastogenesis, osteoclast activation, osteoclast survival, bone resorption, TNF superfamily, receptor activator of NF-kappaB, osteoprotegerin, bone turnover
MeSH terms: Animals, Bone Resorption, Cell Differentiation, Humans, Osteoclasts, Osteogenesis, Signal Transduction, Bone Remodeling, Mice, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

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Functions of RANKL/RANK/OPG in bone modeling and remodeling

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