Cited by 5,439Bone Metabolism and DiseasesRheumatoid Arthritis Research and TherapiesBone and Dental Protein Studies

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

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Lacey, D.L, Timms, E, Tan, H.-L, Kelley, M.J, Dunstan, C.R, Burgess, T, Elliott, R, Colombero, A +16 more·1998·Cell

Abstract

The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal cells, vitamin D3, and glucocorticoids in the coculture model of in vitro osteoclastogenesis. OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and stimulates the rapid induction of genes that typify osteoclast development. OPGL directly activates isolated mature osteoclasts in vitro, and short-term administration into normal adult mice results in osteoclast activation associated with systemic hypercalcemia. These data suggest that OPGL is an osteoclast differentiation and activation factor. The effects of OPGL are blocked in vitro and in vivo by OPG, suggesting that OPGL and OPG are key extracellular regulators of osteoclast development.

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Crossref · 10.1016/s0092-8674(00)81569-x

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Authors
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., Hsu, H., Sullivan, J., Hawkins, N., Davy, E., Capparelli, C., Eli, A., Qian, Y.-X., Kaufman, S., Sarosi, I., Shalhoub, V, Senaldi, G., Guo, J., Delaney, J., & Boyle, W. J.
Affiliations
Amgen (United States) (US)
Corresponding author
Boyle, W.J
Venue
Cell
Publisher
Elsevier BV
Published
1998-04
Volume
93
Issue
2
Pages
165-176
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2048299560
Cited by
5,439
References
23
Citations by year
2026: 74 · 2025: 86 · 2024: 96 · 2023: 97 · 2022: 125 · 2021: 171 · 2020: 167 · 2019: 174 · 2018: 174 · 2017: 201 · 2016: 147 · 2015: 211 · 2014: 225 · 2013: 234 · 2012: 272
FWCI
61.29
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
Amgen
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords
osteoprotegerin ligand, osteoprotegerin, osteoclastogenesis, osteoclast activation, hypercalcemia, bone remodeling
MeSH terms
Amino Acid Sequence, Animals, Bone Resorption, Carrier Proteins, Cell Differentiation, Cells, Cultured, Cloning, Molecular, Glycoproteins, Hematopoietic Stem Cells, Humans, Hypercalcemia, Ligands, Membrane Glycoproteins, Molecular Sequence Data, Organ Specificity, Osteoclasts, Protein Binding, Recombinant Fusion Proteins, RNA, Messenger, Macrophage Colony-Stimulating Factor, Cytokines, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Gene Expression Regulation, Developmental, Coculture Techniques, Mice, Rats, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B

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