The DOI matches its Crossref record; 161 of the 161 references it cites were found in a registry or an index.
Bacterial heme-transport proteins and their heme-coordination modes
Abstract
Efficient iron acquisition is critical for an invading microbe’s survival and virulence. Most of the iron in mammals is incorporated into heme, which can be plundered by certain bacterial pathogens as a nutritional iron source. Utilization of exogenous heme by bacteria involves the binding of heme or hemoproteins to the cell surface receptors, followed by the transport of heme into cells. Once taken into the cytosol, heme is presented to heme oxygenases where the tetrapyrrole ring is cleaved in order to release the iron. Some Gram-negative bacteria also secrete extracellular heme-binding proteins called hemophores, which function to sequester heme from the environment. The heme transport genes are often genetically linked as gene clusters under Fur (Ferric uptake repressor) regulation. This review discusses the gene clusters and proteins involved in bacterial heme acquisition, transport and processing processes, with special focus on the heme coordination, protein structures and mechanisms underlying heme transport.
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“Under iron-replete conditions, Fur represses the expression of heme uptake machinery in many species, including S. aureus , Y. pestis , and P. aeruginosa (68, 79, 115, 116).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [116]
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“The HasA system encodes an export complex (HasDEF), a hemophore receptor (HasR), and regulatory proteins (HasI and HasS) (7, 15, 33, 97, 116).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [116]
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In the citing paper
“Many bacterial pathogens have elegant systems dedicated to the acquisition of heme from host hemoproteins.”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [116]
In the citing paper
“Two types of hemophore-mediated heme uptake systems have been described for Gram-negative bacteria: one uses the HasA hemophore, and the other uses the HxuA hemophore (116).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [116]
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“Bacterial pathogens can circumvent nearly every vertebrate form of heme sequestration.”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [116]
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Cites
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Cited by
Iron in infection and immunity
Cassat, J. E., & Skaar, E. P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.04.010 · Cited by 1,214
Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens
Anzaldi, L. L., & Skaar, E. P. (2010) · Infection and Immunity · doi:10.1128/iai.00613-10 · Cited by 295
Iron acquisition strategies of bacterial pathogens
Sheldon, J. R., Laakso, H. A., & Heinrichs, D. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0010-2015 · Cited by 219
Constante, M., Fragoso, G., Calvé, A., Samba-Mondonga, M., & Santos, M. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01809 · Cited by 161
Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity
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Metadata
- Authors
- Tong, Y., & Guo, M.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 481
- Issue
- 1
- Pages
- 1-15
- ISSN
- 0003-9861
- PMC
- PMC2683585
- Cited by
- 162
- References
- 161
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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