Dietary heme induces gut dysbiosis, aggravates colitis, and potentiates the development of adenomas in mice
Open accessAbstract
Dietary heme can be used by colonic bacteria equipped with heme-uptake systems as a growth factor and thereby impact on the microbial community structure. The impact of heme on the gut microbiota composition may be particularly pertinent in chronic inflammation such as in inflammatory bowel disease (IBD), where a strong association with gut dysbiosis has been consistently reported. In this study we investigated the influence of dietary heme on the gut microbiota and inferred metagenomic composition, and on chemically-induced colitis and colitis-associated adenoma development in mice. Using 16S rRNA gene sequencing, we found that mice fed a diet supplemented with heme significantly altered their microbiota composition, characterized by a decrease in -diversity, a reduction of Firmicutes and an increase of Proteobacteria, particularly Enterobacteriaceae. These changes where similar to shifts seen in dextran sodium sulfate (DSS) -treated mice to induce colitis. In addition, dietary heme contributed to the exacerbation of DSS-induced colitis and facilitated adenoma formation in the Azoxymethane/DSS colorectal mouse model. Using inferred metagenomics (PICRUSt), we found that the microbiota alterations elicited by dietary heme resulted in non-beneficial functional shifts, which were also characteristic of DSS-induced colitis. Furthermore, a reduction in fecal butyrate was found in mice fed the heme supplemented diet compared to mice fed the standard diet. Iron metabolism genes known to contribute to heme release from red blood cells, heme uptake, and heme exporter proteins, were significantly enriched, indicating a shift towards favouring the growth of bacteria able to uptake heme and protect against its toxicity. In conclusion, our data suggest that luminal heme, originating from dietary components or gastrointestinal bleeding in IBD and, to lesser extent in CRC, directly contributes to microbiota dysbiosis. Thus, luminal heme levels may further exacerbate colitis through the modulation of the gut microbiota and its metagenomic functional composition. Our data may have implications in the development of novel targets for therapeutic intervention aimed at lowering gastrointestinal heme levels through heme chelation or degradation using probiotics and nutritional interventions.
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Dietary iron drives changes to the microbiota that may increase susceptibility to infection.
“Yet, studies examining the effects of dietary iron suggest iron drives changes to the microbiota that may result in increased susceptibility to infection ((Constante et al., 2017; Jaeggi et al., 2015); Figure 3).”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Constante et al., 2017
Heme supplementation reduces the relative abundance of Firmicutes, which include beneficial butyrate-producing Clostridia.
“For instance, heme (an iron-containing porphyrin molecule) supplementation reduces the relative abundance of Firmicutes (Constante et al., 2017), which contain members from the beneficial butyrate-producing class Clostridia.”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Constante et al., 2017
Members of Enterobacteriaceae are more abundant after dietary heme treatment.
“Furthermore, members of the Enterobacteriaceae are found in greater abundance following dietary heme treatment (Constante et al., 2017).”
From The Impact of Dietary Transition Metals on Host-Bacterial Interactions (2018) · cites this paper as Constante et al., 2017
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- Authors
- Constante, M., Fragoso, G., Calvé, A., Samba-Mondonga, M., & Santos, M. M.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Corresponding author
- Santos, Manuela M.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2017-09-21
- Volume
- 8
- Pages
- 1809-1809
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC5613120
- OpenAlex
- W2753259991
- Cited by
- 161
- References
- 80
- Citations by year
- 2026: 12 · 2025: 18 · 2024: 12 · 2023: 29 · 2022: 20 · 2021: 21 · 2020: 19 · 2019: 15 · 2018: 15
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Canadian Cancer Society Research Institute (CCSRI, Innovation grant #702797)
- Canadian Institutes of Health Research (CIHR, grant #MOP123246)
- Mitacs (acceleration, # IT07618)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut dysbiosis, colitis, colorectal cancer, inflammatory bowel disease, gut microbiota, DSS-induced colitis, butyrate, iron metabolism genes, heme uptake, Enterobacteriaceae, Firmicutes, Proteobacteria
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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