Cited by 211Bone Metabolism and DiseasesAdipokines, Inflammation, and Metabolic DiseasesBone health and osteoporosis research

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Regulation of energy metabolism by the skeleton: Osteocalcin and beyond

Ferron, Mathieu, Lacombe, Julie·2014·Archives of Biochemistry and Biophysics

DOI 10.1016/j.abb.2014.05.022

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Abstract

The skeleton has recently emerged as an endocrine organ implicated in the regulation of glucose and energy metabolism. This function of bone is mediated, at least in part, by osteocalcin, an osteoblast-derived protein acting as a hormone stimulating insulin sensitivity, insulin secretion and energy expenditure. Osteocalcin secretion and bioactivity is in turn regulated by several hormonal cues including insulin, leptin, the sympathetic nervous system and glucocorticoids. Recent findings support the notion that osteocalcin functions and regulations are conserved between mice and humans. Moreover, studies in mice suggest that osteocalcin could represent a viable therapeutic approach for the treatment of obesity and insulin resistance. In this review, we summarize the current knowledge on osteocalcin functions, its various modes of action and the mechanisms implicated in the control of this hormone.

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Authors: Ferron, M., & Lacombe, J.
Affiliations: Montreal Clinical Research Institute (CA)
Corresponding author: Ferron, Mathieu
ORCID: Ferron, Mathieu
Lacombe, Julie
Venue: Archives of Biochemistry and Biophysics
Publisher: Elsevier BV
Published: 2014-11
Volume: 561
Pages: 137-146
ISSN: 0003-9861 (ISSN-L)
DOI: 10.1016/j.abb.2014.05.022
OpenAlex: W2048096271
Cited by: 211
References: 179
Citations by year: 2026: 5 · 2025: 12 · 2024: 15 · 2023: 21 · 2022: 17 · 2021: 16 · 2020: 21 · 2019: 16 · 2018: 20 · 2017: 24 · 2016: 19 · 2015: 19 · 2014: 5
FWCI: 2.10
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Archives of Biochemistry and Biophysics (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords: osteocalcin, bone endocrine function, energy metabolism, glucose metabolism, insulin sensitivity, insulin secretion, energy expenditure, leptin, sympathetic nervous system, glucocorticoids, obesity, insulin resistance, osteoblasts, therapeutic target
MeSH terms: Animals, Bone and Bones, Energy Metabolism, Glucose, Homeostasis, Humans, Insulin, Insulin Resistance, Osteocalcin, Mice

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Regulation of energy metabolism by the skeleton: Osteocalcin and beyond

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