Regulation of energy metabolism by the skeleton: Osteocalcin and beyond

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

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Osteoblastic cells regulate the haematopoietic stem cell niche

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Endocrine regulation of energy metabolism by the skeleton

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Leptin Inhibits Bone Formation through a Hypothalamic Relay

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Leptin Regulates Bone Formation via the Sympathetic Nervous System

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Increased bone formation in osteocalcin-deficient mice

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Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone

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The Osteoblast: A Sophisticated Fibroblast under Central Surveillance

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Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism

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Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice

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ATF4 Is a Substrate of RSK2 and an Essential Regulator of Osteoblast Biology

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Glucocorticoids Act Directly on Osteoblasts and Osteocytes to Induce Their Apoptosis and Reduce Bone Formation and Strength

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Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

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A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

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Endocrine Regulation of Male Fertility by the Skeleton

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Bone recognition mechanism of porcine osteocalcin from crystal structure

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Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins

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Maternal and Offspring Pools of Osteocalcin Influence Brain Development and Functions

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Polycystic ovary syndrome and cardiovascular disease: a premature association?

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Low Body Mass Index Is an Important Risk Factor for Low Bone Mass and Increased Bone Loss in Early Postmenopausal Women

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The adipoinsular axis: effects of leptin on pancreatic β-cells

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Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice

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Regulation of pancreatic beta-cell mass

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Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus

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The vitamin K cycle

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Association between Serum Osteocalcin and Markers of Metabolic Phenotype

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Abdominal adiposity and the polycystic ovary syndrome

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Plasma Osteocalcin Is Inversely Related to Fat Mass and Plasma Glucose in Elderly Swedish Men

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FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts

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Calcium-dependent .alpha.-helical structure in osteocalcin

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Osteopenia in insulin-dependent diabetes mellitus; prevalence and aspects of pathophysiology

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Identification of a Novel Extracellular Cation-sensing G-protein-coupled Receptor

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Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis

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The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

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The Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training

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Molecular regulation of pancreatic β-cell mass development, maintenance, and expansion

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Disruption of leptin receptor expression in the pancreas directly affects β cell growth and function in mice

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GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome

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Adiponectin Regulates Bone Mass via Opposite Central and Peripheral Mechanisms through FoxO1

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Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure

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Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus

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Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a

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Gut-Derived Serotonin Is a Multifunctional Determinant to Fasting Adaptation

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FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

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How Does Type 1 Diabetes Develop?

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The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

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GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

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The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β‐cell function in middle‐aged male subjects

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Vertebral postmenopausal bone loss is reduced in overweight women: a longitudinal study in 155 early postmenopausal women.

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Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Prevents Osteopenia by Promoting Bone Formation and Suppressing Bone Resorption in Aged Ovariectomized Rats

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Impaired gastric acidification negatively affects calcium homeostasis and bone mass

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Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function.

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Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism

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Serum Osteocalcin Is Associated With Measures of Insulin Resistance, Adipokine Levels, and the Presence of Metabolic Syndrome

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Genetic determination of the cellular basis of the sympathetic regulation of bone mass accrual

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Low Serum Osteocalcin Levels in Glucocorticoid-Treated Asthmatics*

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The pancreatic β cell is a key site for mediating the effects of leptin on glucose homeostasis

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Relationship between osteocalcin and glucose metabolism in postmenopausal women

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Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor

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Four-month treatment with GLP-2 significantly increases hip BMD

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Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels

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Osteocalcin Induces Release of Glucagon-Like Peptide-1 and Thereby Stimulates Insulin Secretion in Mice

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γ-Carboxylation of osteocalcin and insulin resistance in older men and women

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Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

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Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes

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Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study

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Bone Gla Protein Increases HIF-1α–Dependent Glucose Metabolism and Induces Cartilage and Vascular Calcification

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Osteocytes Regulate Primary Lymphoid Organs and Fat Metabolism

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A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss

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CREB mediates brain serotonin regulation of bone mass through its expression in ventromedial hypothalamic neuronsPreprint

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An ELISA-based method to quantify osteocalcin carboxylation in mice

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Hyperphagia and Weight Gain after Gold-Thioglucose: Relation to Hypothalamic Neuropeptide Y and Proopiomelanocortin

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Inverse relationship between serum osteocalcin levels and visceral fat area in Chinese men

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Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey

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Change in Undercarboxylated Osteocalcin Is Associated with Changes in Body Weight, Fat Mass, and Adiponectin: Parathyroid Hormone (1-84) or Alendronate Therapy in Postmenopausal Women with Osteoporosis (the PaTH Study)

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Circulating osteocalcin level is associated with improved glucose tolerance, insulin secretion and sensitivity independent of the plasma adiponectin level

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Fetal origins of the metabolic syndrome

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Reduced Serum Concentrations of Carboxylated and Undercarboxylated Osteocalcin Are Associated With Risk of Developing Type 2 Diabetes Mellitus in a High Cardiovascular Risk Population: A Nested Case-Control Study

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Effect of Dexamethasone on Glucose Tolerance and Fat Metabolism in a Diet-Induced Obesity Mouse Model

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Serum levels of osteocalcin are inversely associated with the metabolic syndrome and the severity of coronary artery disease in Chinese men

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In vivo analysis of the contribution of bone resorption to the control of glucose metabolism in mice

Lacombe, J., Karsenty, G., & Ferron, M. (2013) · Molecular Metabolism · doi:10.1016/j.molmet.2013.08.004 · Cited by 89

Osteocalcin Reverses Endoplasmic Reticulum Stress and Improves Impaired Insulin Sensitivity Secondary to Diet-Induced Obesity Through Nuclear Factor-κB Signaling Pathway

Zhou, B., Li, H., Xu, L., Zang, W., Wu, S., & Sun, H. (2013) · Endocrinology · doi:10.1210/en.2012-2144 · Cited by 86

The effect of Pb2+ on the structure and hydroxyapatite binding properties of osteocalcin

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The Neuroendocrine Basis of Anorexia Nervosa and Its Impact on Bone Metabolism

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Associations of total osteocalcin with all-cause and cardiovascular mortality in older men. The Health In Men Study

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Carboxylated and uncarboxylated forms of osteocalcin directly modulate the glucose transport system and inflammation in adipocytes

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Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation.

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Osteocalcin Is Related to Enhanced Insulin Secretion in Gestational Diabetes Mellitus

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The effect of acute exercise on undercarboxylated osteocalcin in obese men

Levinger, I., Zebaze, R., Jerums, G., Hare, D. L., Selig, S. E., & Seeman, E. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1370-7 · Cited by 79

Developmental androgen excess programs sympathetic tone and adipose tissue dysfunction and predisposes to a cardiometabolic syndrome in female mice

Nohara, K., Waraich, R. S., Liu, S., Ferron, M., Waget, A., Meyers, M. S., Karsenty, G., Burcelin, R., & Mauvais-Jarvis, F. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2012 · Cited by 77

FoxO1 Protein Cooperates with ATF4 Protein in Osteoblasts to Control Glucose Homeostasis

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GPRC6A Mediates the Effects of l-Arginine on Insulin Secretion in Mouse Pancreatic Islets

Pi, M., Wu, Y., Lenchik, N. I., Gerling, I., & Quarles, L. D. (2012) · Endocrinology · doi:10.1210/en.2012-1301 · Cited by 75

Total and undercarboxylated osteocalcin predict changes in insulin sensitivity and β cell function in elderly men at high cardiovascular risk

Bulló, M., Moreno‐Navarrete, J. M., Fernández‐Real, J. M., & Salas‐Salvadó, J. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.016642 · Cited by 75

Lower Uncarboxylated Osteocalcin Concentrations in Children with Prediabetes Is Associated with β-Cell Function

Pollock, N. K., Bernard, P. J., Gower, B. A., Gundberg, C. M., Wenger, K., Misra, S., Bassali, R. W., & Davis, C. L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2731 · Cited by 74

Relationships between serum osteocalcin levels versus blood glucose, insulin resistance and markers of systemic inflammation in central Indian type 2 diabetic patients.

Sarkar, P. D., & Choudhury, A. B. (2013) · PubMed · Cited by 70

Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism

Movahed, A., Larijani, B. A., Nabipour, I., Kalantarhormozi, M., Asadipooya, K., Vahdat, K., Akbarzadeh, S., Farrokhnia, M., Assadi, M., Amirinejad, R., et al. (2012) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-012-0367-z · Cited by 68

Bone loss associated with anorexia nervosa

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Osteocalcin, glucose metabolism, lipid profile and chronic low‐grade inflammation in middle‐aged and elderly Chinese

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Carboxylation of Osteocalcin Affects Its Association With Metabolic Parameters in Healthy Children

Prats‐Puig, A., Mas‐Parareda, M., Riera-Pérez, E., González-Forcadell, D., Mier, C., Mallol-Guisset, M., Díaz, M., Bassols, J., de Zegher, F., Ibáñez, L., et al. (2009) · Diabetes Care · doi:10.2337/dc09-1837 · Cited by 64

Serum concentrations of osteocalcin, procollagen type 1 N-terminal propeptide and beta-CrossLaps in obese subjects with varying degrees of glucose tolerance

Iglesias, P., Arrieta, F., Piñera, M., Botella-Carretero, J. I., Balsa, J. A., Zamarrón, I., Menacho, M., Díez, J. J., Muñoz, T. M., & Vázquez, C. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04035.x · Cited by 63

Higher Serum Osteocalcin Is Associated With Lower Abdominal Aortic Calcification Progression and Longer 10-Year Survival in Elderly Men of the MINOS Cohort

Confavreux, C. B., Szulc, P., Casey, R., Boutroy, S., Varennes, A., Vilayphiou, N., Goudable, J., & Chapurlat, R. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3426 · Cited by 63

Effects of Physiological Variations in Circulating Insulin Levels on Bone Turnover in Humans

Basu, R., Peterson, J. M., Rizza, R. A., & Khosla, S. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2877 · Cited by 63

Intermittent injections of osteocalcin reverse autophagic dysfunction and endoplasmic reticulum stress resulting from diet-induced obesity in the vascular tissue via the NFκB-p65-dependent mechanism

Zhou, B., Li, H., Liu, J., Xu, L., Zang, W., Wu, S., & Sun, H. (2013) · Cell Cycle · doi:10.4161/cc.24929 · Cited by 58

Association of Osteocalcin With Obesity, Insulin Resistance, and Cardiovascular Risk Factors in Young Adults

Polgreen, L. E., Jacobs, D. R., Nathan, B. M., Steinberger, J., Moran, A., & Sinaiko, A. R. (2012) · Obesity · doi:10.1038/oby.2012.108 · Cited by 57

The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release

Smajilovic, S., Clemmensen, C., Johansen, L. D., Wellendorph, P., Holst, J. J., Thams, P., Ogo, E., & Bräuner‐Osborne, H. (2012) · Amino Acids · doi:10.1007/s00726-012-1341-8 · Cited by 56

Association between obesity, metabolic risks and serum osteocalcin level in postmenopausal women

Lee, S. W., Jo, H. H., Kim, M. R., You, Y. O., & Kim, J. H. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.633660 · Cited by 55

A reduced serum level of total osteocalcin in men predicts the development of diabetes in a long‐term follow‐up cohort

Ngarmukos, C., Chailurkit, L., Chanprasertyothin, S., Hengprasith, B., Sritara, P., & Ongphiphadhanakul, B. (2011) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2011.04215.x · Cited by 54

Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight

Knapen, M. H. J., Schurgers, L. J., Shearer, M. J., Newman, P., Theuwissen, E., & Vermeer, C. (2011) · British Journal Of Nutrition · doi:10.1017/s000711451100626x · Cited by 54

Relationship between serum osteocalcin and glycaemic variability in Type 2 diabetes

Bao, Y., Zhou, M., Zhou, J., Lu, W., Gao, Y., Pan, X., Tang, J., Lu, H., & Jia, W. (2010) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2010.05463.x · Cited by 54

Relation of Serum Osteocalcin Level to Risk of Coronary Heart Disease in Chinese Adults

Zhang, Y., Qi, L., Gu, W., Yan, Q., Dai, M., Shi, J., Zhai, Y., Chen, Y., Liu, J., Wang, W., et al. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.07.013 · Cited by 53

The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

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Determinants of undercarboxylated and carboxylated osteocalcin concentrations in type 1 diabetes

Thrailkill, K. M., Jo, C.-H., Cockrell, G. E., Moreau, C. S., Lumpkin, C. K., & Fowlkes, J. L. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1807-7 · Cited by 50

Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes

Alfadda, A. A., Masood, A., Shaik, S. A., Dekhil, H., & Goran, M. I. (2013) · International Journal of Endocrinology · doi:10.1155/2013/197519 · Cited by 49

Serum Osteocalcin Is Not Associated with Glucose but Is Inversely Associated with Leptin across Generations of Nondiabetic Women

Lu, C., Ivaska, K. K., Alén, M., Wang, Q., Törmäkangas, T., Xu, L., Wiklund, P., Mikkola, T. M., Pekkala, S., Tian, H., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2045 · Cited by 49

Osteoblast-specific expression of Fra-2/AP-1 controls Adiponectin/Osteocalcin expression and affects metabolism

Bözec, A., Bakiri, L., Jiménez, M., Rosen, E. D., Catalá-Lehnen, P., Schinke, T., Schett, G. A., Amling, M., & Wagner, E. F. (2013) · Journal of Cell Science · doi:10.1242/jcs.134510 · Cited by 48

Cross-Sectional Evidence of a Signaling Pathway from Bone Homeostasis to Glucose Metabolism

Gravenstein, K. S., Napora, J. K., Short, R. G., Ramachandran, R., Carlson, O. D., Metter, E. J., Ferrucci, L., Egan, J. M., & Chia, C. W. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2589 · Cited by 47

Associations of total and undercarboxylated osteocalcin with peripheral and hepatic insulin sensitivity and β-cell function in overweight adults.

Gower, B., Pollock, N. K., Casazza, K., Clemens, T., Goree, L. L. T., & Granger, W. (2013) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jc.2013-1203 · Cited by 47

Serum osteocalcin levels in patients with nonalcoholic fatty liver disease: association with ballooning degeneration

Yilmaz, Y., Kurt, R., Eren, F., & Imeryuz, N. (2011) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2011.604427 · Cited by 46

Circulating Osteocalcin Level Is Not Associated With Incident Type 2 Diabetes in Middle-Aged Male Subjects

Hwang, Y., Jee, J.-H., Jeong, I., Ahn, K. J., Chung, H. Y., & Lee, M. (2012) · Diabetes Care · doi:10.2337/dc11-2471 · Cited by 46

Serum osteocalcin is associated with improved metabolic state via adiponectin in females versus testosterone in males. Gender specific nature of the bone–energy homeostasis axis

Buday, B., Pach, F. P., Literáti-Nagy, B., Vitai, M., Vecsei, Z., & Koranyi, L. I. (2013) · Bone · doi:10.1016/j.bone.2013.07.018 · Cited by 45

Cloning of hOST-PTP: the only example of a protein-tyrosine-phosphatase the function of which has been lost between rodent and human

Cousin, W., Courseaux, A., Ladoux, A., Dani, C., & Peraldi, P. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.137 · Cited by 44

Low Serum Levels of Undercarboxylated Osteocalcin in Postmenopausal Osteoporotic Women Receiving an Inhibitor of Bone Resorption

Aonuma, H., Miyakoshi, N., Hongo, M., Kasukawa, Y., & Shimada, Y. (2009) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.218.201 · Cited by 44

The association between serum osteocalcin levels and metabolic syndrome in Koreans

Bae, S. J., Choe, J. W., Chung, Y. E., Kim, B., Lee, S. H., Kim, H. Y., Koh, J., Kim, H. Y., & Kim, G. S. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1504-y · Cited by 43

Osteocalcin as a marker of metabolic risk in healthy postmenopausal women

García‐Martin, A., Berdonces, M. C., Luque-Fernández, I., Rozas-Moreno, P., Quesada‐Charneco, M., & Muñoz‐Torres, M. (2010) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e3181f8565e · Cited by 43

Relationship between bone biochemical markers versus glucose/lipid metabolism and atherosclerosis; a longitudinal study in type 2 diabetes mellitus

Kanazawa, I., Yamaguchi, T., & Sugimoto, T. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.03.015 · Cited by 42

Young overweight and obese women with lower circulating osteocalcin concentrations exhibit higher insulin resistance and concentrations of C-reactive protein

Lucey, A. J., Paschos, G. K., Þórsdóttir, I., Martínez, J. A., Cashman, K. D., & Kiely, M. E. (2012) · Nutrition Research · doi:10.1016/j.nutres.2012.11.011 · Cited by 42

Knock‐in of nuclear localised β‐galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar

Dacquin, R., Mee, P. J., Kawaguchi, J., Olmsted‐Davis, E. A., Gallagher, J. A., Nichols, J., Lee, K. K., Karsenty, G., & Smith, A. G. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20003 · Cited by 42

Osteocalcin as a predictor of the metabolic syndrome in older persons: a population‐based study

Oosterwerff, M. M., van Schoor, N. M., Lips, P. T. A. M., & Eekhoff, E. M. W. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04391.x · Cited by 41

Association between serum osteocalcin, adiposity and metabolic risk in obese children and adolescents

Garanty‐Bogacka, B., Syrenicz, M., Rać, M. E., Krupa, B., Czaja‐Bulsa, G., Walczak, M., Sowińska­‍-Przepiera, E., & Syrenicz, A. (2013) · Endokrynologia Polska · doi:10.5603/ep.2013.0016 · Cited by 41

GSK-3β Function in Bone Regulates Skeletal Development, Whole-Body Metabolism, and Male Life Span

Gillespie, J. R., Bush, J., Bell, G. I., Aubrey, L. A., Dupuis, H., Ferron, M., Kream, B. E., DiMattia, G. E., Patel, S., Woodgett, J. R., et al. (2013) · Endocrinology · doi:10.1210/en.2013-1155 · Cited by 40

Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus

Mori, K., Emoto, M., Motoyama, K., Lee, E., Yamada, S., Morioka, T., Imanishi, Y., Shoji, T., & Inaba, M. (2012) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-4-53 · Cited by 39

Vitamin D, osteocalcin, and risk for adiposity as comorbidities in middle school children

Boucher‐Berry, C., Speiser, P., Carey, D. E., Shelov, S. P., Accacha, S. D., Fennoy, I., Rapaport, R., Espinal, Y., & ROSENBAUM, M. S. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.550 · Cited by 38

Serum osteocalcin is related to abdominal obesity in Korean obese and overweight men

Kim, S.-H., Lee, J., Im, J., & Hwang, H. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.08.046 · Cited by 37

Serum concentrations of carboxylated osteocalcin are increased and associated with several components of the polycystic ovarian syndrome

Diamanti‐Kandarakis, E., Livadas, S., Katsikis, I., Piperi, C., Mantziou, A., Papavassiliou, A. G., & Panidis, D. (2010) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-010-0211-2 · Cited by 36

Serum osteocalcin levels are inversely associated with abdominal aortic calcification in men with type 2 diabetes mellitus

Ogawa-Furuya, N., Yamaguchi, T., Yamamoto, M., Kanazawa, I., & Sugimoto, T. (2013) · Osteoporosis International · doi:10.1007/s00198-013-2289-6 · Cited by 36

Osteoid osteoma is an osteocalcinoma affecting glucose metabolism

Confavreux, C. B., Borel, O., Lee, F., Vaz, G., Guyard, M., Fadat, C., Carlier, M.-C., Chapurlat, R. D., & Karsenty, G. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1684-0 · Cited by 35

Relationship between serum osteocalcin levels and non‐alcoholic fatty liver disease in Chinese men

Dou, J., Ma, X., Fang, Q., Hao, Y., Yang, R., Wang, F., Zhu, J., Bao, Y., & Jia, W. (2013) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12063 · Cited by 34

T-Cell Protein Tyrosine Phosphatase Regulates Bone Resorption and Whole-Body Insulin Sensitivity through Its Expression in Osteoblasts

Zee, T., Settembre, C., Levine, R. L., & Karsenty, G. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06279-11 · Cited by 34

X-ray Crystal Structure of Bovine 3 Glu-Osteocalcin

Malashkevich, V. N., Almo, S. C., & Dowd, T. L. (2013) · Biochemistry · doi:10.1021/bi4010254 · Cited by 32

Trunk Fat Negatively Influences Skeletal and Testicular Functions in Obese Men: Clinical Implications for the Aging Male

Migliaccio, S., Francomano, D., Bruzziches, R., Greco, E. A., Fornari, R., Donini, L. M., Lenzi, A., & Aversa, A. (2013) · International Journal of Endocrinology · doi:10.1155/2013/182753 · Cited by 32

Changes in Serum Osteocalcin are Not Associated with Changes in Glucose or Insulin for Osteoporotic Patients Treated with Bisphosphonate

Hong, S.-H., Koo, J.-W., Hwang, J. K., Hwang, Y., Jeong, I., Ahn, K. J., Chung, H.-Y., & Kim, D. (2013) · Journal of Bone Metabolism · doi:10.11005/jbm.2013.20.1.37 · Cited by 31

Circulating osteocalcin concentrations are associated with parameters of liver fat infiltration and increase in parallel to decreased liver enzymes after weight loss

Fernández‐Real, J. M., Ortega, F. J., Gómez‐Ambrosi, J., Salvador, J., Frühbeck, G., & Ricart, W. (2010) · Osteoporosis International · doi:10.1007/s00198-010-1174-9 · Cited by 30

Osteocalcin and vitamin D status are inversely associated with homeostatic model assessment of insulin resistance in Canadian Aboriginal and white women: the First Nations Bone Health Study

Weiler, H. A., Lowe, J., Krahn, J., & Leslie, W. D. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.12.007 · Cited by 29

Developmental androgen excess disrupts reproduction and energy homeostasis in adult male mice

Nohara, K., Liu, S., Meyers, M. S., Waget, A., Ferron, M., Karsenty, G., Burcelin, R., & Mauvais-Jarvis, F. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0230 · Cited by 28

Serum osteocalcin levels in relation to metabolic syndrome in Chinese postmenopausal women

Yang, R., Ma, X., Pan, X., Wang, F., Luo, Y., Gu, C., Bao, Y., & Jia, W. (2012) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318271b1da · Cited by 28

Relationship between Serum Osteocalcin Levels and Non-Alcoholic Fatty Liver Disease in Adult Males, South China

Liu, J.-J., Chen, Y., Mo, Z., Tian, G., Tan, A., Gao, Y., Yang, X., Zhang, H., & Li, Z. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141019782 · Cited by 28

Analysis of Osteocalcin as a Candidate Gene for Type 2 Diabetes (T2D) and Intermediate Traits in Caucasians and African Americans

Das, S. K., Sharma, N., & Elbein, S. C. (2010) · Disease Markers · doi:10.1155/2010/246845 · Cited by 28

Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells

Mauro, L. J., Olmsted‐Davis, E. A., Davis, A. R., & Dixon, J. E. (1996) · Endocrinology · doi:10.1210/endo.137.3.8603605 · Cited by 26

Significant association between body composition phenotypes and the osteocalcin genomic region in normative human population

Korostishevsky, M., Malkin, I., Trofimov, S., Pei, Y., Deng, H., & Livshits, G. (2012) · Bone · doi:10.1016/j.bone.2012.07.010 · Cited by 26

Factors influencing insulin sensitivity in patients with mild primary hyperparathyroidism before and after parathyroidectomy

Almqvist, E. G., Bondeson, A., Bondeson, L., Mellström, D., & Svensson, J. (2011) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2011.634432 · Cited by 25

Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans.

Das, S. K., Sharma, N., & Elbein, S. C. (2010) · PubMed · doi:10.3233/dma-2010-0701 · Cited by 25

Relationships Between Osteocalcin, Glucose Metabolism and Adiponectin in Obese Children: Is there Crosstalk Between Bone Tissue and Glucose Metabolism?

Abseyi, S. N., Şıklar, Z., Berberoğlu, M., Hacıhamdioğlu, B., Erdeve, Ş. S., & Öçal, G. (2012) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.831 · Cited by 24

Biochemical Characterization of Osteo-Testicular Protein Tyrosine Phosphatase and Its Functional Significance in Rat Primary Osteoblasts

Chengalvala, M., Bapat, A. R., Hurlburt, W. W., Kostek, B., Gonder, D. S., Mastroeni, R., & Frail, D. E. (2000) · Biochemistry · doi:10.1021/bi0019996 · Cited by 24

Serum Osteocalcin Is Significantly Related to Indices of Obesity and Lipid Profile in Malaysian Men

Chin, K., Ima-Nirwana, S., Mohamed, I. N., Ahmad, F., Ramli, E. S. M., Aminuddin, A., & Ngah, W. Z. W. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.7152 · Cited by 24

Relation of osteocalcin with insulin resistance and histopathological changes of non alcoholic fatty liver disease

Aller, R., Castrillón, J. L. P., de Luis, D. A., Conde, R., Izaola, O., Sagrado, M. G., Velasco, M. C., Alvarez, T., & Pacheco, D. (2011) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31587-x · Cited by 24

A Cut-Point Value of Uncarboxylated to Carboxylated Index is Associated with Glycemic Status Markers in Type 2 Diabetes

Villafán-Bernal, J. R., Llamas-Covarrubias, M. A., Muñóz-Valle, J. F., Rivera-León, E. A., González-Hita, M. E., Bastidas‐Ramírez, B. E., Gurrola‐Díaz, C. M., Armendáriz‐Borunda, J., & Sánchez‐Enríquez, S. (2014) · Journal of Investigative Medicine · doi:10.2310/jim.0000000000000015 · Cited by 23

Relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes

Sarkar, P. D., & Choudhury, A. B. (2012) · Archives of Physiology and Biochemistry · doi:10.3109/13813455.2012.715651 · Cited by 23

CTX (Crosslaps) Rather than Osteopontin Is Associated with Disturbed Glucose Metabolism in Gestational Diabetes

Winhofer, Y., Kiefer, F. W., Handisurya, A., Tura, A., Klein, K., Schneider, B., Marculescu, R., Wagner, O. F., Pacini, G., Luger, A., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040947 · Cited by 21

Serum levels of osteocalcin in relation to glucose metabolism and carotid atherosclerosis in Chinese middle-aged and elderly male adults: The Shanghai Changfeng Study

Ma, H., Lin, H., Hu, Y., Li, X., He, W., Jin, X., Gao, J., Zhao, N., & Gao, X. (2014) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2014.01.017 · Cited by 20

Interactions between adipose, bone, and muscle tissue markers during acute negative energy balance in male rowers.

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Post-menopausal women with rheumatoid arthritis who are treated with raloxifene or alendronate or glucocorticoids have lower serum undercarboxylated osteocalcin levels.

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