Lactucin alleviates liver fibrosis by regulating the TLR4-MyD88-MAPK/NF-κB signaling pathway through intestinal flora

Hepatic inflammatory responses in liver fibrosis

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Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis

Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 624 · see citing works

Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut

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Hepatic fibrosis 2022: Unmet needs and a blueprint for the future

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Intestinal flora and disease mutually shape the regional immune system in the intestinal tract

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Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease

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Metabolic Hallmarks of Hepatic Stellate Cells in Liver Fibrosis

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Role of the Gut–Liver Axis in Liver Inflammation, Fibrosis, and Cancer: A Special Focus on the Gut Microbiota Relationship

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The Protective Effects of Live and Pasteurized Akkermansia muciniphila and Its Extracellular Vesicles against HFD/CCl4-Induced Liver Injury

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Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats

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Short-chain fatty acids, secondary bile acids and indoles: gut microbial metabolites with effects on enteroendocrine cell function and their potential as therapies for metabolic disease

Masse, K. E., & Lu, V. B. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1169624 · Cited by 120 · see citing works

Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies

Frăsinariu, O. E., Ceccarelli, S., Alisi, A., Moraru, E., & Nobili, V. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.11.010 · Cited by 97 · see citing works

Unveiling the complex relationship between gut microbiota and liver cancer: opportunities for novel therapeutic interventions

Rajapakse, J., Khatiwada, S., Akon, A. C., Yu, K. L., Shen, S., & Zekry, A. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2240031 · Cited by 94 · see citing works

Astragaloside IV prevents acute myocardial infarction by inhibiting the TLR4/MyD88/NF‐κB signaling pathway

Shi, H. M., Zhou, P., Gao, G., Liu, P., Wang, S., Song, R., Zou, Y., Yin, G., & Wang, L. (2021) · Journal of Food Biochemistry · doi:10.1111/jfbc.13757 · Cited by 93 · see citing works

Ursolic acid reverses liver fibrosis by inhibiting NOX4/NLRP3 inflammasome pathways and bacterial dysbiosis

Nie, Y., Liu, Q., Zhang, W., Wan, Y., Huang, C., & Zhu, X. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1972746 · Cited by 88 · see citing works

Gut inflammation exacerbates hepatic injury in the high-fat diet induced NAFLD mouse: Attention to the gut-vascular barrier dysfunction

Cheng, C., Tan, J., Qian, W., Zhang, L., & Hou, X. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.08.017 · Cited by 86 · see citing works

The gut microbiota–bile acid axis: A potential therapeutic target for liver fibrosis

Zhang, Y., Li, Z.-J., Gou, H.-Z., Song, X., & Zhang, L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.945368 · Cited by 74 · see citing works

Phillygenin Attenuates Carbon Tetrachloride-Induced Liver Fibrosis via Modulating Inflammation and Gut Microbiota

Wang, C., Ma, C., Fu, K., Gong, L., Zhang, Y., Zhou, H., & Li, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.756924 · Cited by 69 · see citing works

A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway

Meng, X., Kuang, H., Wang, Q., Zhang, H., Wang, D., & Kang, T.-G. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110180 · Cited by 69 · see citing works

Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition

Bai, X., Fu, R., Duan, Z., Liu, Y., Zhu, C., & Fan, D. (2021) · Food & Function · doi:10.1039/d1fo00242b · Cited by 56 · see citing works

Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC Activation

Pan, Q., Gao, M., Kim, D.-M., Ai, W., Yang, W., Jiang, W. G., Brashear, W. A., Dai, Y., Li, S., Sun, Y., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.08.013 · Cited by 51 · see citing works

Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis

Shao, J., Ge, T., Tang, C., Wang, G., Pang, L., & Chen, Z. (2022) · Inflammation Research · doi:10.1007/s00011-022-01629-4 · Cited by 46 · see citing works

Cichorium pumilum Jacq Extract Inhibits LPS-Induced Inflammation via MAPK Signaling Pathway and Protects Rats From Hepatic Fibrosis Caused by Abnormalities in the Gut-Liver Axis

Han, C. L., Wu, X., Zou, N., Zhang, Y., Yuan, J., Gao, Y., Chen, W., Yao, J., Li, C., Hou, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.683613 · Cited by 44 · see citing works

Gut Microbiome Contributes to Liver Fibrosis Impact on T Cell Receptor Immune Repertoire

Liang, Q. D., Zhang, M., Hu, Y., Zhang, W., Zhu, P., Chen, Y., Xue, P., Li, Q., & Wang, K. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.571847 · Cited by 32 · see citing works

Antifibrogenic Influence of Mentha piperita L. Essential Oil against CCl4‐Induced Liver Fibrosis in Rats

Ogaly, H. A., Eltablawy, N. A., & Abd‐Elsalam, R. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4039753 · Cited by 31 · see citing works

Bile acids metabolism involved in the beneficial effects of Danggui Shaoyao San via gut microbiota in the treatment of CCl4 induced hepatic fibrosis

Zhao, Y., Zhao, M., Zhang, Y., Fu, Z., Jin, T., Song, J., Huang, Y., Zhao, C., & Wang, M. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117383 · Cited by 30 · see citing works

Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth

Li, Z., Dong, J., Wang, M., Yan, J., Hu, Y., Liu, Y., Pan, Y., & Li, H. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00463-y · Cited by 29 · see citing works

Sesquiterpenoids with diverse carbon skeletons from the roots of Cichorium glandulosum and their anti-inflammatory activities

Dang, T., Zheng, G., Zhang, Q., Jin, P., Zhang, H., Su, L., Qin, D., & Yao, G. (2019) · Fitoterapia · doi:10.1016/j.fitote.2019.104170 · Cited by 28 · see citing works

MicroRNA‐326 attenuates hepatic stellate cell activation and liver fibrosis by inhibiting TLR4 signaling

Liao, X., Zhan, W., Tian, T., Yu, L., Li, R., & Yang, Q. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29520 · Cited by 22 · see citing works

Huangshui Polysaccharide Exerts Intestinal Barrier Protective Effects through the TLR4/MyD88/NF-κB and MAPK Signaling Pathways in Caco-2 Cells

Huo, J., Pei, W., Liu, G., Sun, W., Wu, J., Huang, M., Lü, W., Sun, J., & Sun, B. (2023) · Foods · doi:10.3390/foods12030450 · Cited by 19 · see citing works

Mechanism of Ulcerative Colitis-Aggravated Liver Fibrosis: The Activation of Hepatic Stellate Cells and TLR4 Signaling Through Gut-Liver Axis

Liu, Y., Niu, G., Li, C., Guo, J., Song, J. M., Li, H., & Zhang, X. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.695019 · Cited by 17 · see citing works

Marine Chitosan-Oligosaccharide Ameliorated Plasma Cholesterol in Hypercholesterolemic Hamsters by Modifying the Gut Microflora, Bile Acids, and Short-Chain Fatty Acids

Abdo, A. A. A., Zhang, C., Al‐Dalali, S., Hou, Y., Gao, J., Yahya, M. A., Saleh, A. Y., Aleryani, H., Al-Zamani, Z. A. S., & Sang, Y. (2023) · Nutrients · doi:10.3390/nu15132923 · Cited by 14 · see citing works

CD73 Blockade Alleviated Hepatic Fibrosis via Inhibiting Hepatic Stellate Cells Proliferation and Activation

Dong, K., Yang, L., Gao, Z., Wu, X., Liu, C., Zhang, J., & Zhang, H. (2023) · Current Molecular Pharmacology · doi:10.2174/1874467216666230322113039 · Cited by 12 · see citing works

Lactucin reverses liver fibrosis by inhibiting TGF-β1/STAT3 signaling pathway and regulating short-chain fatty acids metabolism

Qin, D., Han, C. L., Gao, Y., Li, H., & Zhu, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-70253-5 · Cited by 12 · see citing works

Kuhuang alleviates liver fibrosis by modulating gut microbiota-mediated hepatic IFN signaling and bile acid synthesis

Shen, B., Zhou, C., Gu, T., Shen, Z., Guo, Y., Dai, W., Liu, Y., Zhang, J., Lu, L., & Dong, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1080226 · Cited by 10 · see citing works

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSC-mediated alleviation of decompensated liver cirrhosis in rats

Yao, Y., Zhang, L., Cheng, F., Jiang, Q., Ye, Y., Ren, Y., He, Y., Su, D., Cheng, L., Shi, G., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03416-2 · Cited by 8 · see citing works

The ethanol extract derived from mung bean reduced immune suppression, intestinal injury, and disruptions in gut microbiota caused by cyclophosphamide in mice

Liu, S., Liao, Z., Liu, Y., Bai, J., Huang, Z., Cao, X., Shen, C., Niu, S., & Guo, J. (2025) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.70265 · Cited by 3 · see citing works

Lactucin alleviates lipid accumulation via AMPK-mediated autophagy and fatty acid β-oxidation in FFA-induced HepG2 cells

Ma, X., Aibaidula, Y., Zhang, C., Qi, S., Pang, T., Zhang, J., Hou, W., & Ma, X. (2025) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2025.08.001 · Cited by 3 · see citing works

Strategies to promote liver fibrosis amelioration with involvement of restorative macrophages

Aquino, J. B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1792423 · Cited by 1 · see citing works

Mechanistic Insights into the Protective Effects of Cryptotanshinone Against CCl4-Induced Acute Liver Injury in Mice via Network Pharmacology and Transcriptomics

Zhang, X., Luo, Q., Hu, Y., Gong, P., Zhang, Y., & Zhang, L. (2025) · Biomolecules · doi:10.3390/biom15101449 · Cited by 1 · see citing works

The sesquiterpene lactone components of Cichorium glandulosum suppress both in vitro and in vivo inflammatory responses by reducing IL-1β levels

Ma, X., Qi, S., Qi, S., Zhang, J., Zhang, J., Pang, T., Hou, W., & Ma, X. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-02076-3 · Cited by 1 · see citing works

Observations on the effect of enteral nutrition support on serum nutritional proteins, proinflammatory cytokines and immunoglobulins in patients with cerebral hemorrhage

Tan, W., Li, X., & Tang, X. (2025) · Journal of Medical Biochemistry · doi:10.5937/jomb0-58247 · Cited by 1 · see citing works

Lactobacillus combination alleviates dextran sulfate sodium-induced colitis in Wuzhishan minipigs

Wang, X., Ma, X., Zhang, X., He, Y., Chen, Y., Fu, Q., Yang, Y., Yin, X., & Wu, Z. (2026) · Food & Function · doi:10.1039/d4fo04728a · Cited by 1 · see citing works

Machine learning-driven evaluation of protein kinase D3 as a co-diagnostic biomarker in hepatocellular carcinoma

Li, J., Zhao, Y., Ma, Y., Xie, B., Huang, L., Yang, H., Ma, X., Deng, H., Wang, S., Sun, C., et al. (2026) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2500607 · Cited by 1 · see citing works

Study on the correlation between circadian rhythm, intestinal flora and Liver stiffness in patients with Hepatic fibrosisPreprint

Xiao, Z., Guo, M., Tang, W., Chen, M., & Yang, Q. (2025) · Research Square · doi:10.21203/rs.3.rs-6224838/v1 · Cited by 1 · see citing works

Sinensetin ameliorates established high-fat diet-induced liver injury and intestinal barrier dysfunction through the mitophagy/TLR4/MAPK signaling pathway

Meng, Z., Zhang, Q., Zhao, Z., Zhang, Y., Lu, Z., Liu, G., Xiang, W., Zhang, Q., & Tang, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1812651

From diet to disease modulation: the multi-targeted effects of medicinal-food homologous plants in hepatic fibrosis

Chen, S., Chen, H., Xie, J., Peng, X., Yang, S., Yin, D., & Zhu, Y. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1752309

Cichorium pumilum Jacq Extract Inhibits LPS-Induced Inflammation via MAPK Signaling Pathway and Protects Rats From Hepatic Fibrosis Caused by Abnormalities in the Gut-Liver Axis

Han, C. L., Wu, X., Zou, N., Zhang, Y., Yuan, J., Gao, Y., Chen, W., Yao, J., Li, C., Hou, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.683613 · Cited by 44 · see citing works

Lactucin reverses liver fibrosis by inhibiting TGF-β1/STAT3 signaling pathway and regulating short-chain fatty acids metabolism

Qin, D., Han, C. L., Gao, Y., Li, H., & Zhu, L. (2024) · Scientific Reports · doi:10.1038/s41598-024-70253-5 · Cited by 12 · see citing works

Licorice Total Flavonoids Alleviate Liver Fibrosis by Inhibiting the TGF-β1 Signaling Pathways

Wu, F., Ma, H., Yang, J., & Zhou, B. (2026) · Journal of Visualized Experiments · doi:10.3791/71638

Effect of Cichorium Glandulosum Extracts on CCl4-Induced Hepatic Fibrosis

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Administration of a mixture of triterpenoids from yeyachun and phenolic acids from danshen ameliorates carbon tetrachloride-induced liver fibrosis in mice by the regulation of intestinal flora

Tan, Y., Li, Y., Zhou, F., Guo, J., Wang, T., Shi, Y., Yang, Y., Lu, J., & Pei, G. (2020) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2020.04.007 · Cited by 30 · see citing works