Curcumin-graphene quantum dots for dual mode sensing platform: Electrochemical and fluorescence detection of APOe4, responsible of Alzheimer's disease
Abstract
New dual electrochemical and fluorescence sensitive curcumin-graphene quantum dots sensing platform coated on the transparent Indium-Tin-Oxide electrode was developed to sense APOe4 DNA, responsible of Alzheimer's disease. Curcumin molecule with its dual fluorescence and electrochemical properties was electropolymerized on GQDs-ITO surface. EDC/NHS chemistry was used to covalently immobilize an amino-substituted DNA probe via a malonic acid spacer. Quenching of curcumin signals following hybridized DNA complex was employed to quantify APOe4 DNA. Amperometric studies revealed an ultrasensitive behavior toward the formation of DNA complex with a sensitivity of 4.74 nA.mL.pg -1 and a limit of detection as low as 0.48 pg mL -1 . The platform exhibits very good performances such as repeatability, reproducibility, selectivity and long storage stability. Fluorescence results were established for the support and the complementarity of electrochemical results. Founded results confirmed the ultrasensitivity of platform with comparable performances. Recorded results in human blood plasma demonstrated the high efficacy of curcumin system sensing even in the clinical matrix.
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Mars et al. (2018) described a sensitive method based on dual electrochemical and fluorescence detection of APOE4 DNA, responsible for Alzheimer and coronary artery diseases.
“Mars et al. (2018) described a sensitive method based on dual electrochemical and fluorescence detection of APOE4 DNA, responsible of Alzheimer and coronary artery diseases [114].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [114]
The results showed relative standard deviation c.a. 4.7% toward DNA target in human blood plasma.
“The results showed relative standard deviation c.a. 4.7% toward DNA target in human blood plasma.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [114]
The curcumin-GQDs system exhibited high selectivity and efficacy and was investigated in clinical fluid.
“The curcumin-GQDs system exhibited a high selectivity and efficacy for which it was also investigated in the clinical fluid.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [114]
The analytical response showed a sensitive decrease in the presence of different APO e4 DNA target due to blocked photo-electron transfer activity from DNA complex formation.
“The analytical response showed a sensitive decrease in the presence of different APO e4 DNA target, which was due to the blocked photo-electron transfer activity due to formation of DNA complex.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [114]
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- Authors
- Mars, A., Hamami, M., Bechnak, L., Patra, D., & Raouafi, N.
- Affiliations
- Tunis University (TN)
- American University of Beirut (LB)
- Corresponding author
- Mars, Abdelmoneim
- Venue
- Analytica Chimica Acta
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 1036
- Pages
- 141-146
- ISSN
- 0003-2670 (ISSN-L)
- OpenAlex
- W2848482279
- Cited by
- 127
- References
- 38
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 16 · 2023: 27 · 2022: 16 · 2021: 19 · 2020: 16 · 2019: 11 · 2018: 1
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Analytica Chimica Acta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Keywords
- curcumin, graphene quantum dots, Alzheimer's disease biomarkers, electrochemical DNA biosensor, dual-mode sensing, electropolymerization, indium tin oxide electrode, DNA hybridization detection
- MeSH terms
- Alzheimer Disease, Curcumin, Fluorescence, Graphite, Humans, Particle Size, Spectrometry, Fluorescence, Quantum Dots, Apolipoprotein E4, Electrochemical Techniques
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