Multiple biological activities of curcumin: A short review
Abstract
Turmeric (Curcuma longa rhizomes), commonly used as a spice is well documented for its medicinal properties in Indian and Chinese systems of medicine. It has been widely used for the treatment of several diseases. Epidemiological observations, though inconclusive, are suggestive that turmeric consumption may reduce the risk of some form of cancers and render other protective biological effects in humans. These biological effects of turmeric have been attributed to its constituent curcumin that has been widely studied for its anti-inflammatory, anti-angiogenic, anti-oxidant, wound healing and anti-cancer effects. As a result of extensive epidemiological, clinical, and animal studies several molecular mechanisms are emerging that elucidate multiple biological effects of curcumin. This review summarizes the most interesting in vitro and in vivo studies on the biological effects of curcumin.
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Turmeric is well established for anti-inflammatory, antiseptic, antibacterial, antifungal, anticancer, and disinfectant properties.
“Turmeric is well established for its powerful anti-inflammatory, antiseptic, antibacterial, antifungal, anticancer, and disinfectant properties and is used in several different ways, including burning and inhaling the smoke [36,37,38,39,40].”
From A Fumigation-Based Surface Sterilization Approach for Plant Tissue Culture (2021) · cites this paper as [38]
Both fumigation sources have a history of antimicrobial abilities.
“Thus, both the fumigation sources we have employed have a history of antimicrobial abilities.”
From A Fumigation-Based Surface Sterilization Approach for Plant Tissue Culture (2021) · cites this paper as [38]
Cites
Angiogenesis in cancer, vascular, rheumatoid and other disease
Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627 · see citing works
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Inflamed moods: A review of the interactions between inflammation and mood disorders
Rosenblat, J. D., Cha, D. S., Mansur, R. B., & McIntyre, R. S. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2014.01.013 · Cited by 609 · see citing works
Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease
Reddy, P. H., Manczak, M., Yin, X., Grady, M. C., Mitchell, A., Tonk, S., Kuruva, C. S., Bhatti, J. S., Kandimalla, R., Vijayan, M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170512 · Cited by 354 · see citing works
Redox signals in wound healing
Sen, C. K., & Roy, S. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.006 · Cited by 349 · see citing works
Park, S.-Y., Kim, H.-S., Cho, E.-K., Kwon, B.-Y., Phark, S., Hwang, K.-W., & Sul, D. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.05.030 · Cited by 209 · see citing works
Bassani, T. B., Turnes, J. M., Moura, E. L. R., Bonato, J. M., Cóppola-Segovia, V., Zanata, S. M., Oliveira, R. M. M. W., & Vital, M. A. B. F. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.014 · Cited by 134 · see citing works
Mars, A., Hamami, M., Bechnak, L., Patra, D., & Raouafi, N. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.06.075 · Cited by 127 · see citing works
Immunonutrition support for athletes: Nutrition Reviews©, Vol. 66, No. 6
Nieman, D. C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00038.x · Cited by 101 · see citing works
Application of nanoparticles on diagnosis and therapy in gliomas.
Hernández-Pedro, N. Y., Rangel-López, E., Magaña-Maldonado, R., de la Cruz, V. P., Santamaría del Angel, A., Pineda, B., & Sotelo, J. (2013) · BioMed Research International · doi:10.1155/2013/351031 · Cited by 84 · see citing works
Curcumin attenuates glutamate-induced HT22 cell death by suppressing MAP kinase signaling
Suh, H.-W., Kang, S., & Kwon, K.-S. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9365-6 · Cited by 66 · see citing works
The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment
Zieneldien, T., Kim, J., & Cao, C. (2022) · Geriatrics · doi:10.3390/geriatrics7020024 · Cited by 29 · see citing works
“In vitro studies have elucidated that curcumin has the ability to neutralize reactive oxygen species and block lipid peroxidation, with curcumin being determined to have a greater potency than vitamin E [150,151].”
BackgroundA Fumigation-Based Surface Sterilization Approach for Plant Tissue Culture
Sivanesan, I., Muthu, M., Gopal, J., Tasneem, S., Kim, D.-H., & Oh, J.-W. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052282 · Cited by 27 · see citing works
- Authors
- Maheshwari, R. K., Singh, A. K., Gaddipati, J., & Srimal, R. C.
- Affiliations
- Uniformed Services University of the Health Sciences (US)
- Indian Institute of Toxicology Research (IN)
- Corresponding author
- Maheshwari, Radha K.
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2006-03
- Volume
- 78
- Issue
- 18
- Pages
- 2081-2087
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W1991327193
- Cited by
- 1,674
- References
- 1
- Citations by year
- 2026: 23 · 2025: 58 · 2024: 60 · 2023: 73 · 2022: 84 · 2021: 107 · 2020: 118 · 2019: 129 · 2018: 121 · 2017: 105 · 2016: 106 · 2015: 105 · 2014: 91 · 2013: 90 · 2012: 96
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Defense
- National Institutes of Health (5r21at000517-02)
- National Center for Complementary and Integrative Health (5 R21 AT000517-02)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- curcumin, turmeric, anti-inflammatory activity, antiangiogenic activity, antioxidant activity, wound healing, anticancer activity, molecular mechanisms, medicinal plants
- MeSH terms
- Animals, Antineoplastic Agents, Phytogenic, Antioxidants, Curcumin, Humans, Neovascularization, Pathologic, Wound Healing, Anticarcinogenic Agents, Angiogenesis Inhibitors
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