Electrospinning polydioxanone for biomedical applications
Abstract
Polydioxanone (PDS) is a colorless, crystalline, bioabsorbable polymer that was first developed specifically for wound closure sutures. The compatibility, degradation rate, and mechanical properties (including shape memory) of PDS are of interest when considering the design of tissue engineering scaffolds. This research presents the electrospinning of PDS to fabricate unique nanofibrous structures for a variety of biomedical applications. Electrospinning is a polymer processing technique that utilizes an electric field to form fibers from a polymer solution or melt and allows the fabrication of nanofibrous non-woven structures. Results demonstrate the ability to control the fiber diameter of PDS as a function of solution concentrations and the fiber orientation with our prototype electrospinning apparatus. The results also show dependence between the fiber orientation and the elastic modulus, peak stress, and strain to failure of PDS in a uniaxial model.
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PDO was chosen because electrospinning at a particular concentration produces scaffolds with a fairly uniform distribution of fiber sizes and pore sizes.
“PDO was chosen for this study because when electrospun at a particular concentration, it produces scaffolds with a fairly uniform distribution of fiber sizes and pore sizes [18, 20].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [18]
PDO exhibits high flexibility, higher strength retention, slower absorption rate, and lower inflammatory response compared to poly(glycolide lactide) and poly(glycolic acid).
“It exhibits high flexibility, higher strength retention, slower absorption rate, and lower inflammatory response as compared to poly(glycolide lactide) and poly(glycolic acid) [18].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [18]
The surface area to volume ratio formulas given by Boland et al. were used.
“The surface area to volume ratio of the scaffolds was calculated using the formulas given by Boland et al. [18]”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [18]
Both fiber and pore dimensions increase linearly with polymer concentration.
“Both fiber and pore dimensions increase linearly with concentration [18].”
From Macrophage functional polarization (M1/M2) in response to varying fiber and pore dimensions of electrospun scaffolds (2013) · cites this paper as [18]
Cites
A review on polymer nanofibers by electrospinning and their applications in nanocomposites
Huang, Z., Zhang, Y., Kotaki, M., & Ramakrishna, S. (2003) · Composites Science and Technology · doi:10.1016/s0266-3538(03)00178-7 · Cited by 7,567 · see citing works
Electrospinning of Collagen Nanofibers
Matthews, J. A., Wnek, G. E., Simpson, D. G., & Bowlin, G. L. (2002) · Biomacromolecules · doi:10.1021/bm015533u · Cited by 2,253 · see citing works
Self-citationControlling the Fiber Diameter during Electrospinning
Fridrikh, S. V., Yu, J., Brenner, M. P., & Rutledge, G. C. (2003) · Physical Review Letters · doi:10.1103/physrevlett.90.144502 · Cited by 943 · see citing works
Electrospinning of Nanofiber Fibrinogen Structures
Wnek, G. E., Carr, M. E., Simpson, D. G., et al. (2002) · Nano Letters · doi:10.1021/nl025866c · Cited by 555 · see citing works
Self-citationMechanisms of Enhanced Osteoblast Adhesion on Nanophase Alumina Involve Vitronectin
Webster, T. J., Schadler, L. S., Siegel, R. W., & Bizios, R. (2001) · Tissue Engineering · doi:10.1089/10763270152044152 · Cited by 488 · see citing works
Boland, E. D., Wnek, G. E., SIMPSON, D. L., Pawlowski, K. J., & Bowlin, G. L. (2001) · Journal of Macromolecular Science Part A · doi:10.1081/ma-100108380 · Cited by 464 · see citing works
Self-citationPolydioxanone (PDS), a novel monofilament synthetic absorbable suture.
Ray, J. A., Doddi, N., Regula, D. P., et al. (1981) · PubMed · Cited by 274 · see citing works
Human articular chondrocyte adhesion and proliferation on synthetic biodegradable polymer films
Ishaug, S. L. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00155-6 · Cited by 235 · see citing works
Boland, E. D., Telemeco, T. A., Simpson, D. G., Wnek, G. E., & Bowlin, G. L. (2004) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30105 · Cited by 216 · see citing works
Self-citationElectrospinning of Collagen Type II: A Feasibility Study
Matthews, J. A., Boland, E. D., Wnek, G. E., et al. (2003) · Journal of Bioactive and Compatible Polymers · doi:10.1177/0883911503018002003 · Cited by 194 · see citing works
Self-citationBiologic and Synthetic Vascular Prostheses
Stanley, J. C. (1982) · Cited by 125 · see citing works
Stitzel, J. D., Pawlowski, K. J., Wnek, G. E., et al. (2001) · Journal of Biomaterials Applications · doi:10.1106/u2uu-m9qh-y0bb-5gyl · Cited by 120 · see citing works
Self-citationTissue Engineering And Biodegradable Equivalents, Scientific And Clinical Applications
(2002) · Routledge eBooks · doi:10.4324/9780203910672 · Cited by 103 · see citing works
Polylactones, 42. Zn L-lactate-catalyzed polymerizations of 1,4-dioxan-2-one
Kricheldorf, H. R., & Damrau, D. (1998) · Macromolecular Chemistry and Physics · doi:10.1002/(sici)1521-3935(19980601)199:6 · Cited by 98 · see citing works
Effectiveness of operative treatment of internal orbital wall fracture with polydioxanone implant
Kontio, R. K., Suuronen, R., Salonen, O. L. M., et al. (2001) · International Journal of Oral and Maxillofacial Surgery · doi:10.1054/ijom.2001.0067 · Cited by 94 · see citing works
Clinical and Histological Results of Septoplasty With a Resorbable Implant
Boenisch, M., & Mink, A. (2000) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.126.11.1373 · Cited by 72 · see citing works
Attawia, M., Herbert, K. M., Uhrich, K. E., Langer, R., & Laurencin, C. T. (1999) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(1999)48:3 · Cited by 54 · see citing works
Melt behaviour, crystallinity and morphology of poly(p-dioxanone)
Pezzin, A. P. T. (2001) · Polymer · doi:10.1016/s0032-3861(01)00273-7 · Cited by 52 · see citing works
Bennett, S. L., Connolly, K. M., Lee, D. R., et al. (1996) · Bone · doi:10.1016/s8756-3282(96)00130-5 · Cited by 48 · see citing works
von Wild, K. R. H. (1999) · Surgical Neurology · doi:10.1016/s0090-3019(99)00125-1 · Cited by 46 · see citing works
Tissue Engineering and Biodegradable Equivalents: Scientific and Clinical Applications
Timmer, M. D., & Mikos, A. G. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00335-3 · Cited by 44 · see citing works
Bonnet, D., Patkaï, J., Tamisier, D., et al. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00268-5 · Cited by 36 · see citing works
Tissue engineering: a perspective
Bell, E. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240450302 · Cited by 32 · see citing works
Rudert, M., Hirschmann, F., Schulze, M., et al. (2000) · Cells Tissues Organs · doi:10.1159/000016773 · Cited by 12 · see citing works
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Garg, K., Pullen, N. A., Oskeritzian, C. A., Ryan, J. J., & Bowlin, G. L. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.02.065 · Cited by 457 · see citing works
Self-citationMauck, R. L., Baker, B. M., Nerurkar, N. L., Burdick, J. A., Li, W.-J., Tuan, R. S., & Elliott, D. M. (2009) · Tissue Engineering Part B: Reviews · doi:10.1089/ten.teb.2008.0652 · Cited by 213 · see citing works
Angiogenic potential of human macrophages on electrospun bioresorbable vascular grafts
Garg, K., Sell, S. A., Madurantakam, P., & Bowlin, G. L. (2009) · Biomedical Materials · doi:10.1088/1748-6041/4/3/031001 · Cited by 48 · see citing works
Self-citation
- Authors
- Boland, E. D., Coleman, B. D., Barnes, C. P., Simpson, D. G., Wnek, G. E., & Bowlin, G. L.
- Affiliations
- Virginia Commonwealth University (US)
- Corresponding author
- Bowlin, Gary L.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2005-01
- Volume
- 1
- Issue
- 1
- Pages
- 115-123
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2064157289
- Cited by
- 302
- References
- 25
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 15 · 2023: 14 · 2022: 15 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 9 · 2017: 13 · 2016: 20 · 2015: 22 · 2014: 17 · 2013: 17 · 2012: 13
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- polydioxanone, electrospinning, nanofibers, tissue engineering scaffolds, bioresorbable polymers, fiber diameter control, fiber orientation, mechanical properties, elastic modulus, shape memory effect, biodegradation
- MeSH terms
- Biocompatible Materials, Elasticity, Materials Testing, Microscopy, Electron, Scanning, Solutions, Sutures, Tensile Strength, Viscosity, Polydioxanone, Tissue Engineering
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