Cited by 48Electrospun Nanofibers in Biomedical ApplicationsTissue Engineering and Regenerative MedicineBone Tissue Engineering Materials

Angiogenic potential of human macrophages on electrospun bioresorbable vascular grafts

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Garg, K, Sell, S A, Madurantakam, P, Bowlin, G L·2009·Biomedical Materials

Abstract

The aim of this study was to investigate macrophage interactions with electrospun scaffolds and quantify the expression of key angiogenic growth factors in vitro. This study will further help in evaluating the potential of these electrospun constructs as vascular grafts for tissue repair and regeneration in situ. Human peripheral blood macrophages were seeded in serum free media on electrospun (10 mm) discs of polydioxanone (PDO), elastin and PDO:elastin blends (50:50, 70:30 and 90:10). The growth factor secretion was analyzed by ELISA. Macrophages produced high levels of vascular endothelial growth factor and acidic fibroblast growth factor. Transforming growth factor beta-1 (TGF-beta1) secretion was relatively low and there was negligible production of basic fibroblast growth factor. Therefore, it can be anticipated that these scaffolds will support tissue regeneration and angiogenesis.

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Crossref · 10.1088/1748-6041/4/3/031001

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42 of 42 references verified0 citation errors · 0 not checkable

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Authors
Garg, K., Sell, S. A., Madurantakam, P., & Bowlin, G. L.
Affiliations
Virginia Commonwealth University (US)
Venue
Biomedical Materials
Published
2009-04-17
Volume
4
Issue
3
Pages
031001
ISSN
  • 1748-6041 (ISSN-L)
  • 1748-605X
OpenAlex
W1977217812
Cited by
48
References
42
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 7 · 2019: 2 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
1.75
Type
journal article
Language
en
Open access
Locations
  • Biomedical Materials (publishedVersion)
  • PubMed (publishedVersion)
  • VCU Scholars Compass (Virginia Commonwealth University) (submittedVersion)
  • VCULIBRARIES
Topics
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Keywords
macrophages, angiogenesis, electrospun scaffolds, polydioxanone, elastin, vascular endothelial growth factor, acidic fibroblast growth factor, TGF-β1, basic fibroblast growth factor, growth factor secretion, tissue regeneration
MeSH terms
Biocompatible Materials, Bioprosthesis, Blood Vessel Prosthesis, Cells, Cultured, Elastin, Electrochemistry, Humans, Macrophages, Materials Testing, Rotation, Polydioxanone, Neovascularization, Physiologic, Absorbable Implants, Tissue Engineering, Angiogenic Proteins, Transforming Growth Factor beta1

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