Cited by 667Bone Tissue Engineering MaterialsConcrete and Cement Materials ResearchMicrobial Applications in Construction Materials

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Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties

Zhang, Jingtao, Liu, Weizhen, Schnitzler, Verena, Tancret, Franck, Bouler, Jean-Michel·2014·Acta Biomaterialia

DOI 10.1016/j.actbio.2013.11.001

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Abstract

Since their initial formulation in the 1980s, calcium phosphate cements (CPCs) have been increasingly used as bone substitutes. This article provides an overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties. Many processing parameters, such as particle size, composition of cement reactants and additives, can be adjusted to control the setting process of CPCs, concomitantly influencing their handling and mechanical performance. Moreover, this review shows that, although the mechanical strength of CPCs is generally low, it is not a critical issue for their application for bone repair--an observation not often realized by researchers and clinicians. CPCs with compressive strengths comparable to those of cortical bones can be produced through densification and/or homogenization of the cement matrix. The real limitation for CPCs appears to be their low fracture toughness and poor mechanical reliability (Weibull modulus), which have so far been only rarely studied.

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Authors: Zhang, J., Liu, W., Schnitzler, V., Tancret, F., & Bouler, J.-M.
Affiliations: Inserm (FR)
Institut des Matériaux Jean Rouxel (FR)
Corresponding author: Bouler, Jean-Michel
ORCID: Zhang, Jingtao
Liu, Weizhen
Schnitzler, Verena
Tancret, Franck
Bouler, Jean-Michel
Venue: Acta Biomaterialia
Publisher: Elsevier BV
Published: 2014-03
Volume: 10
Issue: 3
Pages: 1035-1049
ISSN: 1742-7061 (ISSN-L)
DOI: 10.1016/j.actbio.2013.11.001
OpenAlex: W1996760356
Cited by: 667
References: 205
Citations by year: 2026: 26 · 2025: 40 · 2024: 43 · 2023: 49 · 2022: 49 · 2021: 69 · 2020: 88 · 2019: 69 · 2018: 69 · 2017: 76 · 2016: 46 · 2015: 31 · 2014: 11
FWCI: 2.75
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Acta Biomaterialia (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Physical Sciences › Engineering › Civil and Structural Engineering › Concrete and Cement Materials Research
Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
Keywords: calcium phosphate cement, bone substitutes, setting kinetics, setting time, injectability, cohesion, mechanical properties, compressive strength, fracture toughness, Weibull modulus, densification, homogenization, particle size, bone regeneration
MeSH terms: Bone Cements, Calcium Phosphates, Humans, Kinetics, Bone Substitutes, Mechanical Phenomena

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Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties

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