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Cited by 667Bone Tissue Engineering MaterialsConcrete and Cement Materials ResearchMicrobial Applications in Construction Materials

The DOI matches its Crossref record; 202 of the 205 references it cites were found in a registry or an index.

Calcium phosphate cements for bone substitution: Chemistry, handling and mechanical properties

Zhang, Jingtao, Liu, Weizhen, Schnitzler, Verena, Tancret, Franck, Bouler, Jean-Michel·2014·Acta Biomaterialia
DOI 10.1016/j.actbio.2013.11.001
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Abstract

Since their initial formulation in the 1980s, calcium phosphate cements (CPCs) have been increasingly used as bone substitutes. This article provides an overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties. Many processing parameters, such as particle size, composition of cement reactants and additives, can be adjusted to control the setting process of CPCs, concomitantly influencing their handling and mechanical performance. Moreover, this review shows that, although the mechanical strength of CPCs is generally low, it is not a critical issue for their application for bone repair--an observation not often realized by researchers and clinicians. CPCs with compressive strengths comparable to those of cortical bones can be produced through densification and/or homogenization of the cement matrix. The real limitation for CPCs appears to be their low fracture toughness and poor mechanical reliability (Weibull modulus), which have so far been only rarely studied.

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Crossref · 10.1016/j.actbio.2013.11.001

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3 of the 205 references couldn’t be matched to a known paper.

Research works printed but not linked: 5

  1. Brown, 1983, A new calcium phosphate setting cement, J Dent Res, 62, 672
  2. LeGeros, 1982, Apatitic calcium phosphates: possible dental restorative materials, J Dent Res, 61, 343
  3. Andrianjatovo, 1995, Effects of polysaccharides on the cement properties in the monocalcium phosphate β-tricalcium phosphate system, Innovation et technologie en biologie et medecine, 16, 140
  4. Weibull W. A statistical theory of the strength of materials. Ingeniörs Vetenskaps Akademiens–Handlingar 1939;151:1–45.
  5. Davies, 1973, The statistical approach to engineering design in ceramics, Proc Br Ceram Soc, 22, 429

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Metadata

Authors
Zhang, J., Liu, W., Schnitzler, V., Tancret, F., & Bouler, J.-M.
Affiliations
  • Inserm (FR)
  • Institut des Matériaux Jean Rouxel (FR)
Corresponding author
Bouler, Jean-Michel
ORCID
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2014-03
Volume
10
Issue
3
Pages
1035-1049
ISSN
1742-7061 (ISSN-L)
DOI
10.1016/j.actbio.2013.11.001
OpenAlex
W1996760356
Cited by
667
References
205
Citations by year
2026: 26 · 2025: 40 · 2024: 43 · 2023: 49 · 2022: 49 · 2021: 69 · 2020: 88 · 2019: 69 · 2018: 69 · 2017: 76 · 2016: 46 · 2015: 31 · 2014: 11
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Acta Biomaterialia (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Civil and Structural Engineering › Concrete and Cement Materials Research
  • Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
Keywords
calcium phosphate cement, bone substitutes, setting kinetics, setting time, injectability, cohesion, mechanical properties, compressive strength, fracture toughness, Weibull modulus, densification, homogenization, particle size, bone regeneration
MeSH terms
Bone Cements, Calcium Phosphates, Humans, Kinetics, Bone Substitutes, Mechanical Phenomena

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