The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Hydrogel substrate stress-relaxation regulates the spreading and proliferation of mouse myoblasts
Open accessAbstract
Mechanical properties of the extracellular microenvironment are known to alter cellular behavior, such as spreading, proliferation or differentiation. Previous studies have primarily focused on studying the effect of matrix stiffness on cells using hydrogel substrates that exhibit purely elastic behavior. However, these studies have neglected a key property exhibited by the extracellular matrix (ECM) and various tissues; viscoelasticity and subsequent stress-relaxation. As muscle exhibits viscoelasticity, stress-relaxation could regulate myoblast behavior such as spreading and proliferation, but this has not been previously studied. In order to test the impact of stress relaxation on myoblasts, we created a set of two-dimensional RGD-modified alginate hydrogel substrates with varying initial elastic moduli and rates of relaxation. The spreading of myoblasts cultured on soft stress-relaxing substrates was found to be greater than cells on purely elastic substrates of the same initial elastic modulus. Additionally, the proliferation of myoblasts was greater on hydrogels that exhibited stress-relaxation, as compared to cells on elastic hydrogels of the same modulus. These findings highlight stress-relaxation as an important mechanical property in the design of a biomaterial system for the culture of myoblasts.
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Cites
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Loebel, C., Mauck, R. L., & Burdick, J. A. (2019) · Nature Materials · doi:10.1038/s41563-019-0307-6 · Cited by 402
Janmey, P. A., Fletcher, D. A., & Reinhart-King, C. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 422
Qiu, Z., Zhu, H., Wang, Y., Kasimu, A., Li, D., & He, J. (2023) · Bio-Design and Manufacturing · doi:10.1007/s42242-022-00225-z · Cited by 36
Metadata
- Authors
- Bauer, A., Gu, L., Kwee, B., Li, W. A., Dellacherie, M., Celiz, A. D., & Mooney, D. J.
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 62
- Pages
- 82-90
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2752873907
- Cited by
- 180
- References
- 9
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- green
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- Bauer, A., Gu, L., Kwee, B., Li, W. A., Dellacherie, M., Celiz, A. D., & Mooney, D. J. (2017). Hydrogel substrate stress-relaxation regulates the spreading and proliferation of mouse myoblasts. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2017.08.041
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