3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy.
Abstract
Toward the aim of personalized treatment, three-dimensional (3D) printing technology has been widely used in bone tissue engineering owing to its advantage of a fast, precise, and controllable fabrication process. Conventional bioceramic scaffolds are mainly used for bone tissue engineering; however, there has been a significant change in the application of bioceramic scaffolds during the past several years. Therefore, this review focuses on 3D-printed bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties. Further, this review highlights 3D-printed bioceramic scaffolds for applications extending from bone tissue regeneration to bone tumor therapy. This review emphasizes recent developments in functional 3D-printed bioceramic scaffolds with the ability to be used for both tumor therapy and bone tissue regeneration. Considering the challenges in bone tumor therapy, these functional bioceramic scaffolds have a great potential in repairing bone defects induced by surgery and kill the possibly residual tumor cells to achieve bone tumor therapy. Finally, a brief perspective regarding future directions in this field was also provided. The review not only gives a summary of the research developments in bioceramic science but also offers a new therapy strategy by extending multifunctions of traditional biomaterials toward a specific disease. Statement of significance This review outlines the development tendency of 3D-printed bioceramic scaffolds for applications ranging from bone tissue regeneration to bone tumor therapy. Conventional bioceramic scaffolds are mainly used for bone tissue engineering; however, there has been a significant change in the application of bioceramic scaffolds during the past several years. Therefore, this review focuses on 3D-printed bioceramic scaffolds with different compositions and hierarchical structures (macro, micro, and nano scales), and their effects on the mechanical, degradation, permeability, and biological properties. Further, this review highlights 3D-printed bioceramic scaffolds for applications extending from bone tissue regeneration to bone tumor therapy. This review emphasizes recent developments in the functional 3D-printed bioceramic scaffolds with the ability to be used for both bone tumor therapy and bone tissue regeneration.
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3D printing technologies can accurately and quickly fabricate scaffolds with precise geometry and high pore connectivity, similar to native tissues.
“it can accurately and quickly fabricate scaffolds with precise geometry and high pore connectivity, similar to native tissues [13][14][15][16][17]”
From A strategy to tailor the mechanical and degradation properties of PCL-PEG-PCL based copolymers for biomedical application (2023) · cites this paper as [13]
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- Authors
- Ma, H., Feng, C., Chang, J., & Wu, C.
- Affiliations
- Chinese Academy of Sciences (CN)
- Corresponding author
- Wu, Chengtie
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 79
- Pages
- 37-59
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2888878293
- Cited by
- 512
- References
- 0
- Citations by year
- 2026: 32 · 2025: 46 · 2024: 73 · 2023: 84 · 2022: 83 · 2021: 78 · 2020: 68 · 2019: 45
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Research and Development Program of China (2018YFB1105501)
- Natural Science Foundation of China (5171101275, 81771989, 81601612)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Automotive Engineering › Additive Manufacturing and 3D Printing Technologies
- Keywords
- bone tissue engineering, bone regeneration, hierarchy, scaffold mechanical properties, scaffold degradation, scaffold permeability, bone defects, personalized treatment, multifunctional biomaterials
- MeSH terms
- Animals, Biocompatible Materials, Bone and Bones, Ceramics, Humans, Neoplasms, Tissue Engineering, Tissue Scaffolds, Printing, Three-Dimensional
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