Current status and prospects of metal-organic frameworks for bone therapy and bone repair
Abstract
With the development of society, traumatic bone defects caused by accidents, diseases and surgeries have become common, eventually resulting in an increase in bone defects. The treatment of bone defects is characterized by a long period of treatment, high cost and uncontrollable outcomes. Also, it results in complications such as infection and bone discontinuity. Hence, due to this situation, the physical, mental and financial aspects of the patient are severely affected. What's more, such outcomes pose a challenge to orthopaedic surgeons. As a result, bone therapy and bone repair have become a hot topic of interest. In repairing bone defects, materials other than autogenous bone are still unable to provide good biocompatibility, osteogenesis, osteoconductivity and osteoinduction properties at the same time. In addition, the scarcity of autologous bone sources has forced the search for new autologous bone replacement materials. Metal organic frameworks (MOFs) are a new class of developed functional materials that have been widely used in the biomedical field during the recent years due to their porous nature, large specific surface area and diverse structures. With the progress in the investigation into bone treatment and repair, more and more investigators are using MOFs in bone therapy and bone repair. With these viewpoints, in the present perspective, the use of MOFs in bone therapy and bone repair has been summarized, and an insight into the future of MOFs in bone therapy and bone repair has been provided.
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The osteogenic effects of MOFs have been widely reported, and MOFs can be used as osteoinductive materials, delivering growth factors or drugs and constructing bone graft scaffolds.
“The osteogenic effects of MOFs have been widely reported, and MOFs can be used as osteoinductive materials, delivering growth factors or drugs and constructing bone graft scaffolds [[35], [36], [37]].”
From Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation (2025) · cites this paper as [36]
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Si, Y., Li, X., Dong, S., Gao, X., Zhu, Y., Mo, L., Wang, Z., Wang, S., & Zhang, C. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.026 · Cited by 17 · see citing works
- Authors
- Li, M., Yin, S., Lin, M., Chen, X., Pan, Y., Peng, Y., Sun, J., Kumar, A., & Liu, J.
- Affiliations
- Guangdong Medical College (CN)
- University of Lucknow (IN)
- Corresponding author
- Sun, Jianbo
- Kumar, Abhinav
- Liu, Jianqiang
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2022
- Volume
- 10
- Issue
- 27
- Pages
- 5105-5128
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W4283722004
- Cited by
- 156
- References
- 152
- Citations by year
- 2026: 8 · 2025: 16 · 2024: 45 · 2023: 67 · 2022: 20
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Education of Guangdong Province (20202ZDZX2046 and 2021ZDZX2052)
- Guangdong Medical Research Foundation (PF100-1-03)
- Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded Scheme (4SG22006G)
- Guangzhou Science, Technology and Innovation Commission (pdjh2021a0218, pdjh2022a0217, pdjh2022b0225 and pdjh20220224)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Organic Frameworks: Synthesis and Applications
- Health Sciences › Medicine › Epidemiology › Bone fractures and treatments
- Keywords
- metal-organic frameworks, bone regeneration, bone defects, bone substitutes, bone formation, osteoconductivity, osteoinduction, porous media, biocompatibility
- MeSH terms
- Metal-Organic Frameworks, Humans, Osteogenesis, Porosity
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