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Cited by 282

The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.

The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity

Open access
Brash, John L., Horbett, Thomas A., Latour, Robert A., Tengvall, Pentti·2019·Acta Biomaterialia

Abstract

The adsorption of proteins is the initiating event in the processes occurring when blood contacts a “foreign” surface in a medical device, leading inevitably to thrombus formation. Knowledge of protein adsorption in this context has accumulated over many years but remains fragmentary and incomplete. Moreover, the significance and relevance of the information for blood compatibility are not entirely agreed upon in the biomaterials research community. In this review, protein adsorption from blood is discussed under the headings “agreed upon” and “not agreed upon or not known” with respect to: protein layer composition, effects on coagulation and complement activation, effects on platelet adhesion and activation, protein conformational change and denaturation, prevention of nonspecific protein adsorption, and controlling/tailoring the protein layer composition.

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Crossref · 10.1016/j.actbio.2019.06.022

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Metadata

Authors
Brash, J. L., Horbett, T. A., Latour, R. A., & Tengvall, P.
Venue
Acta Biomaterialia
Publisher
Elsevier BV
Published
2019-08
Volume
94
Pages
11-24
ISSN
1742-7061 (ISSN-L)
OpenAlex
W2952534170
Cited by
282
References
138
FWCI
8.17
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity. https://app.cochat.ai/papers/10.1016/j.actbio.2019.06.022
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Brash, J. L., Horbett, T. A., Latour, R. A., & Tengvall, P. (2019). The blood compatibility challenge. Part 2: Protein adsorption phenomena governing blood reactivity. Acta Biomaterialia. https://doi.org/10.1016/j.actbio.2019.06.022

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.