Zwitterionic hydrogels implanted in mice resist the foreign-body reaction
Abstract
The performance of implantable biomedical devices is impeded by the foreign-body reaction, which results in formation of a dense collagenous capsule that blocks mass transport and/or electric communication between the implant and the body. No known materials or coatings can completely prevent capsule formation. Here we demonstrate that ultra-low-fouling zwitterionic hydrogels can resist the formation of a capsule for at least 3 months after subcutaneous implantation in mice. Zwitterionic hydrogels also promote angiogenesis in surrounding tissue, perhaps owing to the presence of macrophages exhibiting phenotypes associated with anti-inflammatory, pro-healing functions. Thus, zwitterionic hydrogels may be useful in a broad range of applications, including generation of biocompatible implantable medical devices and tissue scaffolds.
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During the first week PCBMA attracted fewer inflammatory cells and after three months displayed minimum FBC formation with increased blood-vessel density around the implant compared to PHEMA implants.
“During the first week PCBMA attracted fewer inflammatory cells and after three months displayed minimum FBC formation with increased blood‐vessel density around the implant compared to PHEMA implants.”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [207]
Hydrogels loaded with ultralow-fouling zwitterionic ions have shown to completely negate in vivo capsule formation of FBR for at least 3 months while promoting angiogenesis in surrounding microenvironment.
“Hydrogels loaded with ultralow‐fouling zwitterionic ions have already shown to completely negate the in vivo capsule formation of the FBR for a period of at least 3 months while also promoting angiogenesis in the surrounding microenvironment.[ 207 ]”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [207]
Low-fouling materials prevent FBR-triggering non-specific protein adsorption.
“Certain features of material chemistry can also be exploited to beneficially influence FBR, such as the use of low-fouling materials which prevent FBR-triggering non-specific protein adsorption (Figure 1) (Zhang et al., 2013; Xie et al., 2018).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Zhang et al., 2013
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- Authors
- Zhang, L., Cao, Z., Bai, T., Carr, L., Ella-Menye, J.-R., Irvin, C., Ratner, B. D., & Jiang, S.
- Affiliations
- University of Washington (US)
- Venue
- Nature Biotechnology
- Published
- 2013-05-12
- Volume
- 31
- Issue
- 6
- Pages
- 553-556
- ISSN
- 0733-222X (ISSN-L)
- 1087-0156
- 1546-1696
- OpenAlex
- W2053058794
- Cited by
- 1,035
- References
- 27
- Citations by year
- 2026: 79 · 2025: 89 · 2024: 91 · 2023: 68 · 2022: 79 · 2021: 107 · 2020: 108 · 2019: 79 · 2018: 87 · 2017: 66 · 2016: 62 · 2015: 45 · 2014: 57 · 2013: 16
- FWCI
- 27.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- zwitterionic hydrogels, foreign body reaction, implant biocompatibility, angiogenesis, macrophage phenotype, anti-inflammatory macrophages, biomedical implants, tissue engineering scaffolds, subcutaneous implantation, fouling resistance
- MeSH terms
- Animals, Biocompatible Materials, Foreign-Body Reaction, Macrophages, Prostheses and Implants, Hydrogels, Amino Acid Transport Systems, Neutral, Mice
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