The tissue origin effect of extracellular vesicles on cartilage and bone regeneration

Multilineage potential of adult human mesenchymal stem cells

Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

Dominici, M., Le Blanc, K., Mueller, I., Slaper-Cortenbach, I., Marini, F. C., Krause, D. S., Deans, R. J., Keating, A., Prockop, D. J., & Horwitz, E. M. (2006) · Cytotherapy · doi:10.1080/14653240600855905 · Cited by 17,766

The biology , function , and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770

Universal sample preparation method for proteome analysis

Wiśniewski, J. R., Zougman, A., Nagaraj, N., & Mann, M. (2009) · Nature Methods · doi:10.1038/nmeth.1322 · Cited by 8,352

UniProt: the Universal Protein knowledgebase

Apweiler, R. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkh131 · Cited by 7,593

Reassessment of exosome composition

Jeppesen, D. K., Fenix, A. M., Franklin, J. L., Higginbotham, J. N., Zhang, Q., Zimmerman, L. J., Liebler, D. C., Ping, J., Liu, Q., Evans, R., et al. (2019) · Cell · doi:10.1016/j.cell.2019.02.029 · Cited by 2,975

Exosomes

Pegtel, D. M., & Gould, S. J. (2019) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-013118-111902 · Cited by 2,682

UniProt: the universal protein knowledgebase

The UniProt Consortium (2018) · Nucleic Acids Research · doi:10.1093/nar/gky092 · Cited by 2,043

Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

Gnecchi, M., He, H., Liang, O. D., Melo, L. G., Morello, F., Mu, H., Noiseux, N., Zhang, L., Pratt, R. E., Ingwall, J. S., et al. (2005) · Nature Medicine · doi:10.1038/nm0405-367 · Cited by 1,677

Extracellular Vesicles: Unique Intercellular Delivery Vehicles

Maas, S. L. N., Breakefield, X. O., & Weaver, A. M. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.11.003 · Cited by 1,466

Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration

Xing, H., Zhang, Z., Mao, Q., Wang, C., Zhou, Y., Zhou, X., Ying, L., Xu, H., Hu, S., & Zhang, N. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00991-5 · Cited by 299

Exosome-functionalized magnesium-organic framework-based scaffolds with osteogenic, angiogenic and anti-inflammatory properties for accelerated bone regeneration.

Kang, Y., Xu, C., Meng, L., Dong, X., Qi, M., & Jiang, D. (2022) · Bioactive materials · doi:10.1016/j.bioactmat.2022.02.012 · Cited by 253

Chitosan hydrogel/3D-printed poly(ε‐caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on tetrahedral framework nucleic acid recruitment

Li, P., Fu, L., Liao, Z., Peng, Y., Ning, C., Gao, C., Zhang, D., Sui, X., Lin, Y., Liu, S., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121131 · Cited by 191

3D Printing of Microenvironment‐Specific Bioinspired and Exosome‐Reinforced Hydrogel Scaffolds for Efficient Cartilage and Subchondral Bone Regeneration

Li, Q., Yu, H., Zhao, F., Cao, C., Wu, T., Fan, Y., Ao, Y., & Hu, X. (2023) · Advanced Science · doi:10.1002/advs.202303650 · Cited by 186

Bioinspired Mild Photothermal Effect-Reinforced Multifunctional Fiber Scaffolds Promote Bone Regeneration

Zhang, X., Li, Q., Li, L., Ouyang, J., Wang, T., Chen, J., Hu, X., Ao, Y., Qin, D., Zhang, L., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c11486 · Cited by 167

Articular cartilage repair biomaterials: strategies and applications

Wang, M., Wu, Y., Li, G., Lin, Q., Zhang, W., Liu, H., & Su, J. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100948 · Cited by 145

Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine

Li, M., Fang, F., Sun, M., Zhang, Y., Hu, M., & Zhang, J. (2022) · Theranostics · doi:10.7150/thno.72812 · Cited by 121

Digital light processing (DLP)‐based (bio)printing strategies for tissue modeling and regeneration

Li, H., Dai, J., Wang, Z., Zheng, H., Li, W., Wang, M., & Cheng, F. (2022) · Aggregate · doi:10.1002/agt2.270 · Cited by 130

Recent advances in the use of extracellular vesicles from adipose-derived stem cells for regenerative medical therapeutics

Yang, S., Sun, Y., & Yan, C. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02603-4 · Cited by 122

Exosomes-loaded electroconductive nerve dressing for nerve regeneration and pain relief against diabetic peripheral nerve injury

Yang, Q., Su, S., Liu, S., Yang, S. L., Xu, J., Zhong, Y., Yang, Y., Tian, L., Tan, Z., Wang, J., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.02.024 · Cited by 91

Hydrogels for ameliorating osteoarthritis: Mechanical modulation, anti‐inflammation, and regeneration

Jiang, X., Sun, Y., Lyu, Y., Kang, H., Zhao, J., Zhang, K., & Bian, L. (2024) · BMEMat · doi:10.1002/bmm2.12078 · Cited by 78

Mesenchymal Stem Cell-Derived Extracellular Vesicles for Bone Defect Repair

Wang, D., Cao, H., Hua, W., Gao, L., Yuan, Y. J., Zhou, X., & Zeng, Z. (2022) · Membranes · doi:10.3390/membranes12070716 · Cited by 74

Curcumin primed ADMSCs derived small extracellular vesicle exert enhanced protective effects on osteoarthritis by inhibiting oxidative stress and chondrocyte apoptosis

Xu, C., Zhai, Z., Ying, H., Lü, L., Zhang, J., & Zeng, Y. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01339-3 · Cited by 72

Adipose-derived mesenchymal stem cells (MSCs) are a superior cell source for bone tissue engineering

Gou, Y., Huang, Y., Luo, W., Li, Y., Zhao, P., Zhong, J., Dong, X., Guo, M., Li, A., Hao, A., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.12.003 · Cited by 81

Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes

Sun, M., Li, Q., Yu, H., Cheng, J., Wu, N., Shi, W., Zhao, F., Shao, Z., Meng, Q., Chen, H., et al. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.017 · Cited by 70

Engineering of MSC-Derived Exosomes: A Promising Cell-Free Therapy for Osteoarthritis

Cheng, J., Sun, Y., Ma, Y., Ao, Y., Hu, X., & Meng, Q. (2022) · Membranes · doi:10.3390/membranes12080739 · Cited by 69

Mesenchymal stem cell-derived exosomes as a promising cell-free therapy for knee osteoarthritis

Luo, D., Zhu, H., Li, S., Wang, Z., & Xiao, J. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1309946 · Cited by 69

Mesenchymal Stem Cell-Derived Extracellular Vesicles for Osteoarthritis Treatment: Extracellular Matrix Protection, Chondrocyte and Osteocyte Physiology, Pain and Inflammation Management

Nguyen, T. H., Duong, C. M., Nguyen, X., & Than, U. T. T. (2021) · Cells · doi:10.3390/cells10112887 · Cited by 62

A multifunctional self-reinforced injectable hydrogel for enhancing repair of infected bone defects by simultaneously targeting macrophages, bacteria, and bone marrow stromal cells

Du, J., Chu, Y., Hu, Y., Liu, J., Liu, H., Wang, H., Yang, C., Wang, Z., Yu, A., & Ran, J. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.10.014 · Cited by 60

Mechanism of Action of Mesenchymal Stem Cell-Derived Exosomes in the Intervertebral Disc Degeneration Treatment and Bone Repair and Regeneration

Liang, W., Han, B., Hai, Y., Sun, D., & Yin, P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.833840 · Cited by 60

Exosomes as Potential Functional Nanomaterials for Tissue Engineering

Yao, Y., Jiang, Y., Song, J., Wang, R., Li, Z., Yang, L., Wu, W., Zhang, L., & Peng, Q. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201989 · Cited by 59

Bone Cell Exosomes and Emerging Strategies in Bone Engineering

Vig, S., & Fernandes, M. H. (2022) · Biomedicines · doi:10.3390/biomedicines10040767 · Cited by 52

Injectable exosome-loaded quaternized chitosan/oxidized sodium alginate hydrogel with self-healing, bioadhesive, and antibacterial properties for treating combined radiation-wound injury

Peng, G., Hu, J. X., Guo, J., Dong, J., Zhao, Y., Ye, T., Xiao, F., Meng, Z., Gan, H. K., Gu, R., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152933 · Cited by 49

MiR-21 regulating PVT1/PTEN/IL-17 axis towards the treatment of infectious diabetic wound healing by modified GO-derived biomaterial in mouse models

Chen, X., Peng, Y., Xue, H., Liu, G., Wang, N., & Shao, Z. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01516-4 · Cited by 47

Emerging advances in hydrogel-based therapeutic strategies for tissue regeneration

Li, W., Hu, J., Chen, C., Li, X., Zhang, H., Xin, Y., Tian, Q., & Wang, S. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.09.007 · Cited by 48

Comparison of three different acidic solutions in tendon decellularized extracellular matrix bio-ink fabrication for 3D cell printing

Zhao, F., Cheng, J., Zhang, J., Yu, H., Dai, W., Yan, W., Sun, M., Ding, G., Li, Q., Meng, Q., et al. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.026 · Cited by 48

Effects of Hydrogels on Mesenchymal Stem/Stromal Cells Paracrine Activity and Extracellular Vesicles Production

García‐Aponte, O. F., Kahlenberg, S., Kouroupis, D., Egger, D., & Kasper, C. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70057 · Cited by 51

Functional hydrogels for the repair and regeneration of tissue defects

Li, X., Xu, M., Geng, Z., & Liu, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1190171 · Cited by 46

Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway

Fu, H., Sen, L., Zhang, F., Liu, S., Wang, M., Mi, H., Liu, M., Li, B., Peng, S., Hu, Z., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02214-5 · Cited by 44

Update on the role of extracellular vesicles in rheumatoid arthritis

Miao, H.-B., Wang, F., Lin, S., & Chen, Z. (2022) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2021.33 · Cited by 43

The Delivery and Activation of Growth Factors Using Nanomaterials for Bone Repair

Li, Y., Xu, C., & Lei, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15031017 · Cited by 43

Enhanced osteochondral repair with hyaline cartilage formation using an extracellular matrix-inspired natural scaffold

Dai, W., Cheng, J., Yan, W., Cao, C., Zhao, F., Li, Q., Hu, X., Wang, J., & Ao, Y. (2023) · 中国科学通报：英文版 · doi:10.1016/j.scib.2023.07.050 · Cited by 42

Exosomes loaded with chondrogenic stimuli agents combined with 3D bioprinting hydrogel in the treatment of osteoarthritis and cartilage degeneration

Zhang, H., Huang, J., & Alahdal, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115715 · Cited by 44

Congenital microtia patients: the genetically engineered exosomes released from porous gelatin methacryloyl hydrogel for downstream small RNA profiling, functional modulation of microtia chondrocytes and tissue-engineered ear cartilage regeneration

Chen, J., Huang, T., Liu, R., Wang, C., Jiang, H., & Sun, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01352-6 · Cited by 42

Exosomes from M2c macrophages alleviate intervertebral disc degeneration by promoting synthesis of the extracellular matrix via MiR ‐124/ CILP / TGF ‐β

Liu, Y., Xue, M., Han, Y., Li, Y., Xiao, B., Wang, W., Yu, J., & Ye, X. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10500 · Cited by 38

Mesenchymal stem cell-derived extracellular vesicles/exosome: A promising therapeutic strategy for intracerebral hemorrhage

Zou, Y., Liao, L., Dai, J., Mazhar, M., Yang, G., Wang, H., Dechsupa, N., & Wang, L. (2023) · Regenerative Therapy · doi:10.1016/j.reth.2023.01.006 · Cited by 42

Extracellular Vesicles: a Promising cell-free Therapy for Cartilage Repair

Amsar, R. M., Wijaya, C. H., Ana, I. D., Hidajah, A. C., Notobroto, H. B., Wungu, T. D. K., & Barlian, A. (2021) · Future Science OA · doi:10.2144/fsoa-2021-0096 · Cited by 38

Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway

Wang, Z., Yang, H., Xu, X., Hu, H., Bai, Y., Hai, J., Cheng, L., & Zhu, R. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.08.023 · Cited by 37

Biomimetic synthesis and optimization of extracellular vesicles for bone regeneration

Song, X., Xu, L., & Zhang, W. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.01.057 · Cited by 35

The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation

Yin, H., Li, M., Tian, G., Ma, Y., Ning, C., Yan, Z., Wu, J., Ge, Q., Sui, X., Liu, S., et al. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00300-7 · Cited by 35

Exosomes based strategies for cardiovascular diseases: Opportunities and challenges

Li, H., Zhang, J., Tan, M., Yin, Y., Song, Y., Zhao, Y., Lin, Y., Li, N., Zhang, X., Bai, J., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122544 · Cited by 36

The Therapeutic Role of ADSC-EVs in Skin Regeneration

Wang, Y., Cheng, L., Zhao, H., Li, Z., Chen, J., Cen, Y., & Zhang, Z. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.858824 · Cited by 34

Novel injectable adhesive hydrogel loaded with exosomes for holistic repair of hemophilic articular cartilage defect

Yang, Q., Liu, G., Chen, G., Chen, G., Chen, K., Fan, L., Tu, Y., Chen, J., Shi, Z., Chen, C., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.08.018 · Cited by 34

Urine-Derived Stem Cells for Regenerative Medicine: Basic Biology, Applications, and Challenges

Huang, Y., He, T., Cui, J., Jiang, Y., Zeng, J.-F., Zhang, W., & Xie, H. (2022) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2021.0142 · Cited by 30

Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs

Wang, C., Stöckl, S., Li, S., Herrmann, M., Lukas, C., Reinders, Y., Sickmann, A., & Grässel, S. (2022) · Cells · doi:10.3390/cells11162491 · Cited by 30

Current understanding of MSC-derived exosomes in the management of knee osteoarthritis

Jeyaraman, M., Muthu, S., Shehabaz, S., Jeyaraman, N., Rajendran, R. L., Hong, C. M., Nallakumarasamy, A., Packkyarathinam, R. P., Sharma, S., Ranjan, R., et al. (2022) · Experimental Cell Research · doi:10.1016/j.yexcr.2022.113274 · Cited by 29

Current applications of adipose-derived mesenchymal stem cells in bone repair and regeneration: A review of cell experiments, animal models, and clinical trials

Zhang, Z., Yang, X., Cao, X., Qin, A., & Zhao, J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.942128 · Cited by 29

rBMSC osteogenic differentiation enhanced by graphene quantum dots loaded with immunomodulatory layered double hydroxide nanoparticles

Wang, Z., Yang, H., Bai, Y., Cheng, L., & Zhu, R. (2021) · Biomedical Materials · doi:10.1088/1748-605x/ac4324 · Cited by 28

Comparison of the ability of exosomes and ectosomes derived from adipose-derived stromal cells to promote cartilage regeneration in a rat osteochondral defect model

Xu, T., Yu, X., Xu, K., Lin, Y., Wang, J., Pan, Z., Fang, J., Wang, S., Zhou, Z., Song, H., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03632-4 · Cited by 26

Physicochemical Modulation Strategies for Mass Production of Extracellular Vesicle

Park, H., Seo, Y., Arai, Y., & Lee, S. (2025) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-025-00726-9 · Cited by 28

Mesenchymal stem cells and extracellular vesicles for knee osteoarthritis: clinical application, mechanism exploration and prospect

Li, Y., Fu, T., Yu, W., Wen, H., Wang, Z., Lyu, Z., Wen, X., Ba, T., Chen, Z., Shan, K., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04783-8 · Cited by 27

From Bench to Bedside: The Role of Extracellular Vesicles in Cartilage Injury Treatment

Pan, J., Liu, H. L., Chen, X., Liu, W. X., & Jiang, T. (2024) · Biomaterials Research · doi:10.34133/bmr.0110 · Cited by 26

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying MicroRNA-181c-5p Promote BMP2-Induced Repair of Cartilage Injury through Inhibition of SMAD7 Expression

Zhang, Q., Cao, L., Zou, S., Feng, Y., Miao, X., Huang, L., & Wu, Y. (2022) · Stem Cells International · doi:10.1155/2022/1157498 · Cited by 25

Recent advances in 3D printing hydrogel for topical drug delivery

Zhang, Y., & Wang, C. (2022) · MedComm – Biomaterials and Applications · doi:10.1002/mba2.11 · Cited by 27

Mesenchymal stem cell–derived extracellular vesicles in joint diseases: Therapeutic effects and underlying mechanisms

Wu, J., Wu, J., Liu, Z., Gong, Y., Feng, D., Xiang, W., Fang, S., Chen, R., Wu, Y., Huang, S., et al. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.07.005 · Cited by 25

Extracellular vesicles as therapeutic tools in regenerative dentistry

Xia, E. J., Zou, S., Zhao, X., Liu, W., Zhang, Y., & Zhao, I. S. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03936-5 · Cited by 24

Adipose Mesenchymal Stem Cell-Derived Exosomes as Nanocarriers for Treating Musculoskeletal Disorders

Tang, A., Shu, Q., Jia, S., Lai, Z., & Tian, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s486622 · Cited by 27

Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint

Yang, B., Li, X., Fu, C., Cai, W., Meng, B., Qu, Y., Kou, X., & Zhang, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1158744 · Cited by 27

Exosomes Derived from Adipose Tissue-Derived Mesenchymal Stromal Cells Prevent Medication-Related Osteonecrosis of the Jaw through IL-1RA

Zheng, Y., Dong, X., Wang, X., Wang, J., Chen, S., He, Y., An, J., He, L., & Zhang, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108694 · Cited by 25

Extracellular vesicles: Emerged as a promising strategy for regenerative medicine

Wang, D., & Pan, J. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i4.165 · Cited by 25

Management of Rheumatoid Arthritis: Possibilities and Challenges of Mesenchymal Stromal/Stem Cell-Based Therapies

Shimizu, Y., Ntege, E. H., Azuma, C., Uehara, F., Toma, T., Higa, K., Yabiku, H., Matsuura, N., Inoue, Y., & Sunami, H. (2023) · Cells · doi:10.3390/cells12141905 · Cited by 27

A quick and innovative pipeline for producing chondrocyte-homing peptide-modified extracellular vesicles by three-dimensional dynamic culture of hADSCs spheroids to modulate the fate of remaining ear chondrocytes in the M1 macrophage-infiltrated microenvironment

Chen, J., Zhang, E., Wan, Y., Huang, T., Wang, Y., & Jiang, H. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02567-5 · Cited by 22

Mesenchymal stromal/stem cells from perinatal sources: biological facts, molecular biomarkers, and therapeutic promises

Allouh, M. Z., Rizvi, S. F. A., Alamri, A., Jimoh, Y., Aouda, S., Ouda, Z. H., Hamad, M. I. K., Perez-Cruet, M. J., & Chaudhry, G. R. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04254-0 · Cited by 28

Cartilage 3D bioprinting for rhinoplasty using adipose‐derived stem cells as seed cells: Review and recent advances

Zhang, C., Wang, G., Lin, H., Shang, Y., Liu, N., Zhen, Y., & An, Y. (2023) · Cell Proliferation · doi:10.1111/cpr.13417 · Cited by 22

Diatomite-incorporated hierarchical scaffolds for osteochondral regeneration

Deng, C., Chen, Q., Li, Z., Lu, L., Tong, Y., Yuan, J., Yin, F., Cheng, Y., & Wu, C. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.004 · Cited by 22

Functional Hydrogels and Their Applications in Craniomaxillofacial Bone Regeneration

Yu, Y., Yu, T., Wang, X., & Liu, D. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010150 · Cited by 21

Effects of hydroxyapatite-coated porous titanium scaffolds functionalized by exosomes on the regeneration and repair of irregular bone

Shao, H., Zhang, Q., Sun, M., Wu, M., Sun, X., Wang, Q., & Tong, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1283811 · Cited by 21

Advancements in extracellular vesicle targeted therapies for rheumatoid arthritis: insights into cellular origins, current perspectives, and emerging challenges

Jouybari, M. T., Mojtahedi, F., Babaahmadi, M., Faeed, M., Eslaminejad, M. B., & Taghiyar, L. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03887-x · Cited by 22

Extracellular Vesicle-Integrated Biomaterials in Bone Tissue Engineering Applications: Current Progress and Future Perspectives

Huang, Y. L., & Xie, H. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s522198 · Cited by 20

Diagnostic and Therapeutic Role of Extracellular Vesicles in Articular Cartilage Lesions and Degenerative Joint Diseases

Qiao, K., Chen, Q., Cao, Y., Li, J., Xu, G., Liu, J., Cui, X., Tian, K., & Zhang, W. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.698614 · Cited by 20

Emerging Role of Extracellular Vesicles in Intercellular Communication in the Brain: Implications for Neurodegenerative Diseases and Therapeutics

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Injectable decellularized extracellular matrix hydrogel with cell-adaptable supramolecular network enhances cartilage regeneration by regulating inflammation and facilitating chondrogenesis

Dai, W., Gong, X., Wang, C., Liu, P., Shi, W., Cheng, J., Cao, C., Hu, X., Wang, J., & Ao, Y. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155138 · Cited by 20

Kartogenin-Loaded Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Enhance Chondrogenesis and Expedite Tendon Enthesis Healing in a Rat Model of Rotator Cuff Injury

Wang, Y., Qin, J., Xie, C.-Y., Peng, X.-Z., Wang, J., & Wang, S. (2024) · The American Journal of Sports Medicine · doi:10.1177/03635465241296141 · Cited by 20

A deformable SIS/HA composite hydrogel coaxial scaffold promotes alveolar bone regeneration after tooth extraction

Ma, S., Li, Y., Yao, S., Shang, Y., Li, R., Ling, L., Fu, W., Wei, P., Zhao, B., Zhang, X., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.12.008 · Cited by 20

3D-printed biomimetic bone scaffold loaded with lyophilized concentrated growth factors promotes bone defect repair by regulation the VEGFR2/PI3K/AKT signaling pathway

Liu, X., Zhou, J., Chen, M., Chen, S., You, J., Li, Y., Lv, H., Zhang, Y., & Zhou, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136938 · Cited by 19

Exosome-loaded tannic acid–thioctic acid hydrogel enhances wound healing in coagulation disorders

Tu, Y., Zheng, W., Ding, Z., Xiang, J., Yang, Q., Liu, Y., Cao, J., Shen, Y., Tang, Z., Lin, S., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101496 · Cited by 19

Strategies to Convert Cells into Hyaline Cartilage: Magic Spells for Adult Stem Cells

Kurenkova, A. D., Romanova, I. A., Kibirskiy, P. D., Timashev, P. S., & Medvedeva, E. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911169 · Cited by 21

Mesenchymal Stromal Cells-Derived Extracellular Vesicles as Potential Treatments for Osteoarthritis

Yuan, S., Li, G., Zhang, J., Chen, X., Su, J., & Zhou, F. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071814 · Cited by 18

Mussel-inspired functionalization of electrospun scaffolds with polydopamine-assisted immobilization of mesenchymal stem cells-derived small extracellular vesicles for enhanced bone regeneration

Xing, X., Han, S., Ni, Y., Cheng, G., Cheng, Y., Ni, X., Deng, Y., Li, Z., & Li, Z. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121136 · Cited by 18

Adipose stem cells-released extracellular vesicles as a next-generation cargo delivery vehicles: a survey of minimal information implementation, mass production and functional modification

Chen, J., Liu, R., Huang, T., Sun, H., & Jiang, H. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02849-5 · Cited by 18

Engineered hsa‐miR‐455‐3p‐Abundant Extracellular Vesicles Derived from 3D‐Cultured Adipose Mesenchymal Stem Cells for Tissue‐Engineering Hyaline Cartilage Regeneration

Chen, J., Zhang, E., Wan, Y., Huang, T., Wang, Y., & Jiang, H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304194 · Cited by 19

Exosomes in cartilage microenvironment regulation and cartilage repair

Longfei, H., Hou, W., Weihua, F., Peng, P., Sun, L., Lin, K. C., He, M., Fan, Y., He, W., & Qiushi, W. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1460416 · Cited by 18

3D-printed advanced scaffold armed with exosomes derived from human skeletal stem cell identified by single-cell RNA sequencing enhances osteochondral regeneration

Lou, W., Qiu, X., Qin, Y., Lu, Y., Cao, Y. B., & Lü, H. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.04.028 · Cited by 17

Advances in hydrogel systems for bone regeneration: trends, innovations, and prospects

Han, Y., Liu, J., Hu, C., Wang, Y., & He, C. (2025) · Journal of Materials Chemistry B · doi:10.1039/d5tb02041g · Cited by 18

Non-bone-derived exosomes: a new perspective on regulators of bone homeostasis

Wang, P., Shao, W., Li, Z., Wang, B., Lv, X., Huang, Y., & Feng, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01431-7 · Cited by 19

Comparison of morphology, protein concentration, and size distribution of bone marrow and Wharton's jelly-derived mesenchymal stem cells exosomes isolated by ultracentrifugation and polymer-based precipitation techniques

Rahmatinejad, F., Kharat, Z., Jalili, H., Renani, M. K., & Mobasheri, H. (2024) · Tissue and Cell · doi:10.1016/j.tice.2024.102427 · Cited by 19

Extracellular Vesicle-Functionalized Scaffolds Augment Bone Regeneration

Yu, T., Zhao, I. S., Mohammad, A. F., Yang, J., Liu, J., Wang, H., Deng, Y., & Zhang, Y. (2022) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2024.100945 · Cited by 16

Injectable HAMA-CPC hydrogels loaded with high-yield 3D bioprinted adipose-derived stem cell small extracellular vesicles for increased bone repair

Xu, W., Gao, W., Zhang, Y., Hou, G., Zhang, W., Deng, J., Wang, K., Xu, Y., Liu, B., Xu, T., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03596-4 · Cited by 16

Novel bilayer cell patch combining epidermal stem cells and angiogenic adipose stem cells for diabetic wound healing

Ma, T., Ye, Z., Shen, G., Chai, B., Wang, W., Li, X., Zhang, Z., & Meng, Q. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.06.010 · Cited by 15

Effect of nHA/CS/PLGA delivering adipose stem cell-derived exosomes and bone marrow stem cells on bone healing—in vitro and in vivo studies

Wang, T., Guo, S., & Zhang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-76672-8 · Cited by 15

An injectable antibacterial wet-adhesive for meniscal cartilage regeneration via immune homeostasis mediated by SMSC-derived extracellular vesicles

Huang, M., Yuan, Z., Fu, G., Dong, J., Sun, Y., Wang, W., Shafiq, M., Cao, H., Mo, X., & Chen, J. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.111970 · Cited by 14

Future perspectives: advances in bone/cartilage organoid technology and clinical potential.

Huang, J., Li, A., Liang, R., Wu, X., Jia, S., Chen, J., Jiao, Z., Li, C., Zhang, X., & Lin, J. (2024) · PubMed Central · doi:10.12336/biomatertransl.2024.04.007 · Cited by 17

Effects of 3D-printed exosome-functionalized brain acellular matrix hydrogel on neuroinflammation in rats following cerebral hemorrhage

Zhang, A., Sun, B., Nan, C., Cong, L., Zhao, Z., & Liu, L. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04332-3 · Cited by 15

Advances in graphene-based 2D materials for tendon, nerve, bone/cartilage regeneration and biomedicine

Gao, Y.-X., Wang, X., & Fan, C.-Y. (2024) · iScience · doi:10.1016/j.isci.2024.110214 · Cited by 15

Exosomes derived from bone marrow mesenchymal stem cells induce the proliferation and osteogenic differentiation and regulate the inflammatory state in osteomyelitis in vitro model

Liang, W., Li, Y., Ji, Y., Kang, R., Zhang, K., Su, X., Li, J., Ji, M., Wu, T., Cao, X., et al. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03357-4 · Cited by 15

Exosomal communication: a pivotal regulator of bone homeostasis and a potential therapeutic target

Ye, Q.-Y., Cui, Y. R., Wang, H.-Y., Li, L., Chen, J.-B., Zhu, X., Xue, Z.-J., & Zhang, R. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1516125 · Cited by 14

Global research trends in CRISPR-related technologies associated with extracellular vesicles from 2015 to 2022: a bibliometric, dynamic, and visualized study

Lin, J., Jia, S., Jiao, Z., Chen, J., Li, W., Cao, F., & Zhang, X. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00507-z · Cited by 13

Adipose-derived stem cell exosomes: emerging roles and therapeutic application

Gong, Y., Ma, H., Zheng, Z., Wang, X., Zhang, J., & Zhao, X. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1637342 · Cited by 13

Therapeutic strategy for exosome-based bone regeneration to osteoporosis: Challenges and potential solutions

Dayanandan, A. P., Bello, A. B., Arai, Y., Lee, S. J., & Lee, S.-H. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.042 · Cited by 18

High-precision bioactive scaffold with dECM and extracellular vesicles targeting 4E-BP inhibition for cartilage injury repair

Han, Y., Dong, Y., Jia, B., Shi, X., Zhao, H., Li, S., Wang, H., Sun, B., Yin, L., & Dai, K. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101114 · Cited by 13

Role of Extracellular Vesicles from Adipose Tissue- and Bone Marrow-Mesenchymal Stromal Cells in Endothelial Proliferation and Chondrogenesis

Görgün, C., Palamà, M. E. F., Reverberi, D., Gagliani, M. C., Cortese, K., Tasso, R., & Gentili, C. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.21-0107 · Cited by 47

Extracellular Vesicles in chondrogenesis and Cartilage regeneration

Song, H., Zhao, J., Cheng, J., Feng, Z., Wang, J., Momtazi‐Borojeni, A. A., & Liang, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16290 · Cited by 48

Comparison of the ability of exosomes and ectosomes derived from adipose-derived stromal cells to promote cartilage regeneration in a rat osteochondral defect model

Xu, T., Yu, X., Xu, K., Lin, Y., Wang, J., Pan, Z., Fang, J., Wang, S., Zhou, Z., Song, H., et al. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03632-4 · Cited by 26

Tissue Regeneration Capacity of Extracellular Vesicles Isolated From Bone Marrow-Derived and Adipose-Derived Mesenchymal Stromal/Stem Cells

Liu, Y., & Holmes, C. A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.648098 · Cited by 60

Is Extracellular Vesicle-Based Therapy the Next Answer for Cartilage Regeneration?

Velot, É., Madry, H., Venkatesan, J. K., Bianchi, A., & Cucchiarini, M. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.645039 · Cited by 23