The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Cationic lipids activate intracellular signaling pathways
Abstract
Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a signal of danger by cells or contribute to trigger cascades that are classically activated by endogenous cationic compounds. The present review provides evidence that cationic liposomes activate several cellular pathways like pro-apoptotic and pro-inflammatory cascades. An improved knowledge of the relationship between the cationic lipid properties (nature of the lipid hydrophilic moieties, hydrocarbon tail, mode of organization) and the activation of these pathways opens the way to the use and design of cationic tailored for a specific application (e.g. for gene transport or as adjuvants).
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“Cationic lipids have been associated with the activation of several cellular pathways like pro-apoptotic and pro-inflammatory cascades [65]”
From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [65]
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Metadata
- Authors
- Lonez, C., Vandenbranden, M., & Ruysschaert, J.-M.
- Affiliations
- Université Libre de Bruxelles (BE)
- Corresponding author
- Lonez, Caroline
- ORCID
- Lonez, Caroline
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 64
- Issue
- 15
- Pages
- 1749-1758
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2055351480
- Cited by
- 221
- References
- 92
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 21 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 20 · 2014: 19 · 2013: 12 · 2012: 4
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- cationic liposomes, cationic lipids, intracellular signaling, apoptosis, inflammation, liposome transfection, vaccine adjuvants, gene delivery, lipid structure
- MeSH terms
- Adjuvants, Immunologic, Animals, Antigens, Cations, Humans, Inflammation, Lipids, Liposomes, Transfection, Vaccines, Drug Design, Signal Transduction, Apoptosis
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