The inflammasome: an integrated view

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

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The Inflammasome

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A role for mitochondria in nlrp3 inflammasome activation

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The Inflammasomes

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Gout-associated uric acid crystals activate the NALP3 inflammasome

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Tolerance, Danger, and the Extended Family

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.

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Cryopyrin activates the inflammasome in response to toxins and ATP

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

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IL-10 inhibits cytokine production by activated macrophages

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

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AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

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Calcium, ATP, and ROS: a mitochondrial love-hate triangle

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

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Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

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Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

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Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

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Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme

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Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

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Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

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Lysosomal membrane permeabilization in cell death

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Pro-inflammatory programmed cell death

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Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock

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Selective Mitochondrial Autophagy, or Mitophagy, as a Targeted Defense Against Oxidative Stress, Mitochondrial Dysfunction, and Aging

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

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Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils

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TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY

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Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

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Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

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The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

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The apoptosome: Signalling platform of cell death

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An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

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The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

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Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1

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The genetics and immunopathogenesis of inflammatory bowel disease

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The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

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Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

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Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

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Mouse model of x-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

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The Nalp3 inflammasome is essential for the development of silicosis

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Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

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Rapid Secretion of Interleukin-1β by Microvesicle Shedding

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

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Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

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Natural Interferon α/β–Producing Cells Link Innate and Adaptive Immunity

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

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The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1

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Differential requirement for the activation of the inflammasome for processing and release of IL-1β in monocytes and macrophages

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ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

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Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity.

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The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

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The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

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Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

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CD40/CD154 Interactions at the Interface of Tolerance and Immunity

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Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

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Salmonella induces macrophage death by caspase‐1‐dependent necrosis

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NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ

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Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

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Signaling by ROS drives inflammasome activation

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Cutting Edge: TNF-α Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

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An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

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Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages

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Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production

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NF-κB in the regulation of epithelial homeostasis and inflammation

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Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling

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Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β

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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

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Caspase-1 Activation of Lipid Metabolic Pathways in Response to Bacterial Pore-Forming Toxins Promotes Cell Survival

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IL-1β Processing in Host Defense: Beyond the Inflammasomes

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Lysosomal Membrane Permeabilization Induces Cell Death in a Mitochondrion-dependent Fashion

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MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals

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The Secretory Route of the Leaderless Protein Interleukin 1β Involves Exocytosis of Endolysosome-related Vesicles

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Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

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Identification of Ipaf, a Human Caspase-1-activating Protein Related to Apaf-1

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A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses

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Emerging inflammasome effector mechanisms

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Phospholipases C and A 2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes

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Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity

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Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice.

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Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

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Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

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HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

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NLRs at the intersection of cell death and immunity

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Approaching the Asymptote: 20 Years Later

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Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

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Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

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Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

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Inflammasomes: current understanding and open questions

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Differential Expression of NLRP3 among Hematopoietic Cells

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Adaptive immune cells temper initial innate responses

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NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

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Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes

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IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells.

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TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

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The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock

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Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1

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Caspase 1–independent activation of interleukin‐1β in neutrophil‐predominant inflammation

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Targeting inflammation by modulating the Jun/AP-1 pathway

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Mitochondria and cellular oxygen sensing in the HIF pathway

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Critical functions of priming and lysosomal damage for NLRP3 activation

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Cutting Edge: <i>Candida albicans</i> Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

Joly, S., Ma, N., Sadler, J. J., Soll, D. R., Cassel, S. L., & Sutterwala, F. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901323 · Cited by 296 · see citing works

Mitochondria: Sovereign of inflammation?

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Receptor-Independent, Direct Membrane Binding Leads to Cell-Surface Lipid Sorting and Syk Kinase Activation in Dendritic Cells

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Staphylococcus aureus Evades Lysozyme-Based Peptidoglycan Digestion that Links Phagocytosis, Inflammasome Activation, and IL-1β Secretion

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Caspase-1-dependent processing of pro-interleukin-1β is cytosolic and precedes cell death

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Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells

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T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

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Reactive oxygen species–independent activation of the IL-1β inflammasome in cells from patients with chronic granulomatous disease

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Behçets Disease as an Autoinflammatory Disorder

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Cutting Edge: Critical Role for Mesothelial Cells in Necrosis-Induced Inflammation through the Recognition of IL-1α Released from Dying Cells

Eigenbrod, T., Park, J.-H., Harder, J., Iwakura, Y., & Núñez, G. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8194 · Cited by 228 · see citing works

Cutting Edge: Involvement of the Type I IFN Production and Signaling Pathway in Lipopolysaccharide-Induced IL-10 Production

Chang, E. Y., Guo, B., Doyle, S. E., & Cheng, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6705 · Cited by 228 · see citing works

Regulation of apoptosis by the redox state of cytochrome c

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Lysosomal destabilization in p53-induced apoptosis

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Inflammatory Stimuli Regulate Caspase Substrate Profiles

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Sodium Overload and Water Influx Activate the NALP3 Inflammasome

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Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization

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Physiological Concentrations of K+ Inhibit Cytochrome c-dependent Formation of the Apoptosome

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Cutting Edge: CIAS1/Cryopyrin/PYPAF1/NALP3/ CATERPILLER 1.1 Is an Inducible Inflammatory Mediator with NF-κB Suppressive Properties

O’Connor, W., Harton, J. A., Zhu, X., Linhoff, M. W., & Ting, J. P. ‐. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.12.6329 · Cited by 195 · see citing works

Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection

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Effect of endotoxin in IL-1 β-deficient mice

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Activation of ATP-sensitive K+ (KATP) channels by H2O2 underlies glutamate-dependent inhibition of striatal dopamine release

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TPL-2 negatively regulates interferon-β production in macrophages and myeloid dendritic cells

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Rho is required for the initiation of calcium signaling and phagocytosis by Fcγ receptors in macrophages

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Unconventional Secretion of Fibroblast Growth Factor 2 Is Mediated by Direct Translocation across the Plasma Membrane of Mammalian Cells

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A Reaction-Diffusion Model of ROS-Induced ROS Release in a Mitochondrial Network

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Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration?

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Resistant Behçet Disease Responsive to Anakinra

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Cutting Edge: Necrosis Activates the NLRP3 Inflammasome

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Fcγ-receptors Induce Mac-1 (CD11b/CD18) Mobilization and Accumulation in the Phagocytic Cup for Optimal Phagocytosis

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Monocytes/macrophages and/or neutrophils are the target of IL‐10 in the LPS endotoxemia model

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Interferon-inducible Ifi200-family genes in systemic lupus erythematosus

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Fas-Mediated Apoptosome Formation Is Dependent on Reactive Oxygen Species Derived from Mitochondrial Permeability Transition in Jurkat Cells

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The Role of Potassium in Inflammasome Activation by Bacteria

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Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants

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Tec-Kinase-Mediated Phosphorylation of Fibroblast Growth Factor 2 is Essential for Unconventional Secretion

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Innate immune processes are sufficient for driving silicosis in mice

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SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes

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Lysosomal membrane permeabilization causes oxidative stress and ferritin induction in macrophages

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Intracellular K+ inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release

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Hyperuricaemia and gout: state of the art and future perspectives

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Different patterns of interleukin-1alpha and interleukin-1beta expression in organs of normal young and old mice.

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Initial description of the human NLRP3 promoter

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Octacalcium phosphate crystals induce inflammation in vivo through interleukin‐1 but independent of the NLRP3 inflammasome in mice

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Variants of ribonuclease inhibitor that resist oxidation

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Adaptive control of innate immunity

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Differential susceptibility to lethal endotoxaemia in mice deficient in IL‐1α, IL‐1β or IL‐1 receptor type I

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Tyrosine Kinase 2 Controls IL-1β Production at the Translational Level

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

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Molecular and cellular mechanisms of liver fibrosis and its regression

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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

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NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

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Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

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Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

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Autophagy Links Inflammasomes to Atherosclerotic Progression

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Inflammasomes in carcinogenesis and anticancer immune responses

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Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway

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Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

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Pattern recognition receptors and central nervous system repair

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