Cited by 222RNA Interference and Gene DeliveryImmune Response and InflammationNanoparticle-Based Drug Delivery

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Cationic lipids activate intracellular signaling pathways

Lonez, Caroline, Vandenbranden, Michel, Ruysschaert, Jean-Marie·2012·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2012.05.009

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Abstract

Cationic liposomes are commonly used as a transfection reagent for DNA, RNA or proteins and as a co-adjuvant of antigens for vaccination trials. A high density of positive charges close to cell surface is likely to be recognized as a signal of danger by cells or contribute to trigger cascades that are classically activated by endogenous cationic compounds. The present review provides evidence that cationic liposomes activate several cellular pathways like pro-apoptotic and pro-inflammatory cascades. An improved knowledge of the relationship between the cationic lipid properties (nature of the lipid hydrophilic moieties, hydrocarbon tail, mode of organization) and the activation of these pathways opens the way to the use and design of cationic tailored for a specific application (e.g. for gene transport or as adjuvants).

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See all 222

Authors: Lonez, C., Vandenbranden, M., & Ruysschaert, J.-M.
Affiliations: Université Libre de Bruxelles (BE)
Corresponding author: Lonez, Caroline
ORCID: Lonez, Caroline
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2012-12
Volume: 64
Issue: 15
Pages: 1749-1758
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2012.05.009
OpenAlex: W2055351480
Cited by: 221
References: 92
Citations by year: 2026: 7 · 2025: 13 · 2024: 20 · 2023: 18 · 2022: 21 · 2021: 21 · 2020: 14 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 20 · 2014: 19 · 2013: 12 · 2012: 4
FWCI: 1.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: cationic liposomes, cationic lipids, intracellular signaling, apoptosis, inflammation, liposome transfection, vaccine adjuvants, gene delivery, lipid structure
MeSH terms: Adjuvants, Immunologic, Animals, Antigens, Cations, Humans, Inflammation, Lipids, Liposomes, Transfection, Vaccines, Drug Design, Signal Transduction, Apoptosis

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Cationic lipids activate intracellular signaling pathways

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