Sensing damage by the NLRP3 inflammasome
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Summary: The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase‐1, which leads to the processing and secretion of the proinflammatory cytokines interleukin‐1β (IL‐1β) and IL‐18. Dysregulated NLRP3 inflammasome activation is associated with both heritable and acquired inflammatory diseases. Here, we review new insights into the mechanism of NLRP3 inflammasome activation and its role in disease pathogenesis.
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The NLRP3 inflammasome is implicated in a diverse array of sterile inflammatory diseases including ischemia-reperfusion injury, autoinflammatory diseases, type 2 diabetes, gout and pseudogout, obesity, atherosclerosis, and Alzheimer's disease.
“The NLRP3 inflammasome has been implicated in a diverse array of sterile inflammatory diseases including ischemia-reperfusion injury, autoinflammatory diseases, type 2 diabetes, gout and pseudogout, obesity, atherosclerosis, and Alzheimer's disease (Leemans et al, 2011)”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Leemans et al, 2011
Sterile inflammation is driven in large part by DAMPs that are released after physical and psychological stressors.
“sterile inflammation is driven in large part by DAMPs that are released after physical and psychological stressors (Leemans et al, 2011).”
From Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders (2017) · cites this paper as Leemans et al, 2011
The LRR domain on the NLR is sensitive to a diverse array of danger signals, including ATP.
“The LRR domain is sensitive to a diverse array of danger signals, including ATP (Leemans et al, 2011).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Leemans et al, 2011
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Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works
Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E., & Fitzgerald, K. A. (2009) · Nature · doi:10.1038/nature07725 · Cited by 2,627 · see citing works
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798 · see citing works
Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works
Hoffman, H. M., Mueller, J. L., Broide, D. H., Wanderer, A. A., & Kolodner, R. D. (2001) · Nature Genetics · doi:10.1038/ng756 · Cited by 1,679 · see citing works
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Eisenbarth, S. C., Colegio, O. R., O’Connor, W., Sutterwala, F. S., & Flavell, R. A. (2008) · Nature · doi:10.1038/nature06939 · Cited by 1,542 · see citing works
Self-citationInflammatory Cytokines and the Risk to Develop Type 2 Diabetes
Spranger, J., Kroke, A., Möhlig, M., Hoffmann, K., Bergmann, M. M., Ristow, M., Boeing, H., & Pfeiffer, A. F. H. (2003) · Diabetes · doi:10.2337/diabetes.52.3.812 · Cited by 1,493 · see citing works
Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works
Cooperation of Toll-like receptor signals in innate immune defence
Trinchieri, G., & Sher, A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2038 · Cited by 1,357 · see citing works
Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · see citing works
Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., et al. (2006) · Nature Immunology · doi:10.1038/ni1346 · Cited by 1,131 · see citing works
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works
The apoptosome: Signalling platform of cell death
Riedl, S. J., & Salvesen, G. S. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2153 · Cited by 1,097 · see citing works
Bürckstümmer, T., Baumann, C., Blüml, S., Dixit, E., Dürnberger, G., Jahn, H., Planyavsky, M., Bilban, M., Colinge, J., Bennett, K. L., et al. (2009) · Nature Immunology · doi:10.1038/ni.1702 · Cited by 1,091 · see citing works
Rajamäki, K., Lappalainen, J., Öörni, K., Välimäki, E., Matikainen, S., Kovanen, P. T., & Eklund, K. K. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011765 · Cited by 1,039 · see citing works
Update on Mechanisms of Ischemic Acute Kidney Injury
Devarajan, P. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006010017 · Cited by 1,026 · see citing works
Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease
Meyer-Luehmann, M., Spires-Jones, T. L., Prada, C., Garcia-Alloza, M., de Calignon, A., Rozkalne, A., Koenigsknecht-Talboo, J., Holtzman, D. M., Bacskai, B. J., & Hyman, B. T. (2008) · Nature · doi:10.1038/nature06616 · Cited by 987 · see citing works
Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940 · see citing works
The Nalp3 inflammasome is essential for the development of silicosis
Cassel, S. L., Eisenbarth, S. C., Iyer, S. S., Sadler, J. J., Colegio, O. R., Tephly, L. A., Carter, A. B., Rothman, P. B., Flavell, R. A., & Sutterwala, F. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803933105 · Cited by 907 · see citing works
Self-citationIL-1 pathways in inflammation and human diseases
Gabay, C., Lamacchia, C., & Palmer, G. (2010) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.4 · Cited by 897 · see citing works
Kawaguchi, M., Takahashi, M., Hata, T., Kashima, Y., Usui, F., Morimoto, H., Izawa, A., Takahashi, Y., Masumoto, J., Koyama, J., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.982777 · Cited by 884 · see citing works
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
Boyden, E. D., & Dietrich, W. F. (2006) · Nature Genetics · doi:10.1038/ng1724 · Cited by 860 · see citing works
Active Caspase-1 Is a Regulator of Unconventional Protein Secretion
Keller, M., Rüegg, A., Werner, S., & Beer, H. (2008) · Cell · doi:10.1016/j.cell.2007.12.040 · Cited by 851 · see citing works
McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836 · see citing works
HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA
Roberts, T. L., Idris, A., Dunn, J. A., Kelly, G., Burnton, C. M., Hodgson, S., Hardy, L., Garceau, V., Sweet, M. J., Ross, I. L., et al. (2009) · Science · doi:10.1126/science.1169841 · Cited by 830 · see citing works
Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works
Feldmann, J., Prieur, A., Quartier, P., Berquin, P. C., Dogniaux, S., Cortis, E., Hamel‐Teillac, D., Fischer, A., & Basile, G. D. S. (2002) · The American Journal of Human Genetics · doi:10.1086/341357 · Cited by 737 · see citing works
A pilot study of IL-1 inhibition by anakinra in acute gout
So, A., De Smedt, T., Revaz, S., & Tschopp, J. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2143 · Cited by 727 · see citing works
Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome
Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691 · see citing works
Self-citationStienstra, R., Joosten, L. A. B., Koenen, T. B., van Tits, B. L. J. H., van Diepen, J. A., van den Berg, S. A. A., Rensen, P. C. N., Voshol, P. J., Fantuzzi, G., Hijmans, A., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.011 · Cited by 681 · see citing works
Cutting Edge: Inflammasome Activation by Alum and Alum’s Adjuvant Effect Are Mediated by NLRP3
Li, H., Willingham, S. B., Ting, J. P. ‐., & Re, F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.17 · Cited by 674 · see citing works
Interleukin-1–Receptor Antagonist in the Muckle–Wells Syndrome
Hawkins, P. N., Lachmann, H. J., & McDermott, M. F. (2003) · New England Journal of Medicine · doi:10.1056/nejm200306193482523 · Cited by 654 · see citing works
NALP1 in Vitiligo-Associated Multiple Autoimmune Disease
Jin, Y., Mailloux, C. M., Gowan, K., Riccardi, S. L., LaBerge, G. S., Bennett, D. C., Fain, P. R., & Spritz, R. A. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061592 · Cited by 626 · see citing works
Kool, M., Pétrilli, V., Smedt, T. D., Rolaz, A., Hammad, H., van Nimwegen, M., Bergen, I. M., Castillo, R., Lambrecht, B. N., & Tschopp, J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.6.3755 · Cited by 612 · see citing works
Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney
Leemans, J. C., Stokman, G., Claessen, N., Rouschop, K. M. A., Teske, G. J. D., Kirschning, C. J., Akira, S., van der Poll, T., Weening, J. J., & Florquin, S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22832 · Cited by 563 · see citing works
Self-citationHoffman, H. M., Rosengren, S., Boyle, D. L., Cho, J. Y., Nayar, J., Mueller, J. L., Anderson, J. P., Wanderer, A. A., & Firestein, G. S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17401-1 · Cited by 552 · see citing works
Zamboni, D. S., Kobayashi, K. S., Kohlsdorf, T., Ogura, Y., Long, E. M., Vance, R. E., Kuida, K., Mariathasan, S., Dixit, V. M., Flavell, R. A., et al. (2006) · Nature Immunology · doi:10.1038/ni1305 · Cited by 515 · see citing works
Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome
Sutterwala, F. S., Mijares, L. A., Li, L., Ogura, Y., Kazmierczak, B. I., & Flavell, R. A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071239 · Cited by 509 · see citing works
Self-citationLightfield, K. L., Persson, J., Brubaker, S. W., Witte, C. E., von Moltke, J., Dunipace, E. A., Henry, T., Sun, Y., Cado, D., Dietrich, W. F., et al. (2008) · Nature Immunology · doi:10.1038/ni.1646 · Cited by 487 · see citing works
IDENTIFICATION OF URATE CRYSTALS IN GOUTY SYNOVIAL FLUID
McCarty, D. J., & Hollander, J. L. (1961) · Annals of Internal Medicine · doi:10.7326/0003-4819-54-3-452 · Cited by 485 · see citing works
Franchi, L., & Núñez, G. (2008) · European Journal of Immunology · doi:10.1002/eji.200838549 · Cited by 452 · see citing works
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
Netea, M. G., Joosten, L. A. B., Lewis, E., Jensen, D. R., Voshol, P. J., Kullberg, B. J., Tack, C. J., van Krieken, H., Kim, S.-H., Stalenhoef, A. F., et al. (2006) · Nature Medicine · doi:10.1038/nm1415 · Cited by 424 · see citing works
Central roles of NLRs and inflammasomes in viral infection
Kanneganti, T. (2010) · Nature reviews. Immunology · doi:10.1038/nri2851 · Cited by 421 · see citing works
Abbate, A., Kontos, M. C., Grizzard, J. D., Biondi‐Zoccai, G., Tassell, B. W. V., Robati, R., Roach, L. M., Arena, R. A., Roberts, C. S., Varma, A., et al. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.12.059 · Cited by 418 · see citing works
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
Larsen, C. M., Faulenbach, M., Vaag, A., Ehses, J. A., Donath, M. Y., & Mandrup-Poulsen, T. (2009) · Diabetes Care · doi:10.2337/dc09-0533 · Cited by 401 · see citing works
McKee, A. S., Munks, M. W., MacLeod, M. K. L., Fleenor, C. J., van Rooijen, N., Kappler, J. W., & Marrack, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900164 · Cited by 391 · see citing works
Abbate, A., Salloum, F. N., Vecile, E., Das, A., Hoke, N. N., Straino, S., Biondi‐Zoccai, G., Houser, J.-E., Qureshi, I. Z., Ownby, E. D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.740233 · Cited by 359 · see citing works
CATERPILLERs, pyrin and hereditary immunological disorders
Ting, J. P. ‐., Kastner, D. L., & Hoffman, H. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1788 · Cited by 342 · see citing works
Aluminum Hydroxide Adjuvants Activate Caspase-1 and Induce IL-1β and IL-18 Release
Li, H., Nookala, S., & Re, F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5271 · Cited by 333 · see citing works
Shao, W., Yeretssian, G., Doiron, K., Hussain, S. N. A., & Saleh, M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m708182200 · Cited by 321 · see citing works
Pomerantz, B. J., Reznikov, L. L., Harken, A. H., & Dinarello, C. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041611398 · Cited by 310 · see citing works
Dodé, C., Dû, N. L., Cuisset, L., Letourneur, F., Berthelot, J., Vaudour, G., Meyrier, A. Y., Watts, R. A., Scott, G. I. D., Nicholls, A., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/340786 · Cited by 303 · see citing works
Superoxide dismutase 1 regulates caspase-1 and endotoxic shock
Meissner, F., Molawi, K., & Zychlinsky, A. (2008) · Nature Immunology · doi:10.1038/ni.1633 · Cited by 302 · see citing works
TOLL-LIKE RECEPTORS IN ISCHEMIA-REPERFUSION INJURY
Arumugam, T. V., Okun, E., Tang, S., Thundyil, J., Taylor, S. M., & Woodruff, T. M. (2009) · Shock · doi:10.1097/shk.0b013e318193e333 · Cited by 299 · see citing works
Terkeltaub, R. A., Sundy, J. S., Schumacher, H. R., Murphy, F. T., Bookbinder, S., Biedermann, S., Wu, R., Mellis, S. J., & Radin, A. R. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.108936 · Cited by 297 · see citing works
Why not treat human cancer with interleukin-1 blockade?
Dinarello, C. A. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9229-0 · Cited by 280 · see citing works
Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome
Menu, P., Pellegrin, M., Aubert, J.-F., Bouzourène, K., Tardivel, A., Mazzolai, L., & Tschopp, J. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.18 · Cited by 249 · see citing works
Gartlehner, G., Hansen, R. A., Jonas, B., Thieda, P., & Lohr, K. N. (2006) · PubMed · Cited by 239 · see citing works
Pulskens, W. P. C., Teske, G. J. D., Butter, L. M., Roelofs, J. J. T. H., van der Poll, T., Florquin, S., & Leemans, J. C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003596 · Cited by 233 · see citing works
Self-citationSensing pathogens and danger signals by the inflammasome
Pedra, J. H., Cassel, S. L., & Sutterwala, F. S. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.006 · Cited by 233 · see citing works
di Giovine, F. S., Malawista, S. E., Nuki, G., & Duff, G. W. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.10.3213 · Cited by 231 · see citing works
An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury
Shigeoka, A. A., Mueller, J. L., Kambo, A., Mathison, J. C., King, A. J., Hall, W. F., Correia, J. D. S., Ulevitch, R. J., Hoffman, H. M., & McKay, D. B. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002330 · Cited by 229 · see citing works
Suzuki, K., Murtuza, B., Smolenski, R. T., Sammut, I. A., Suzuki, N., Kaneda, Y., & Yacoub, M. H. (2001) · Circulation · doi:10.1161/hc37t1.094871 · Cited by 202 · see citing works
TLR2 and TLR4 in Ischemia Reperfusion Injury
Arslan, F., Keogh, B., McGuirk, P., & Parker, A. E. (2010) · Mediators of Inflammation · doi:10.1155/2010/704202 · Cited by 192 · see citing works
Moschen, A. R., Molnar, C., Enrich, B., Geiger, S., Ebenbichler, C. F., & Tilg, H. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00108 · Cited by 185 · see citing works
Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1β Transcription in Human Adipose Tissue
Koenen, T. B., Stienstra, R., van Tits, L. J., Graaf, J. D., Stalenhoef, A. F. H., Joosten, L. A. B., Tack, C. J., & Netea, M. G. (2011) · Diabetes · doi:10.2337/db10-0266 · Cited by 172 · see citing works
TLR4 Promotes Fibrosis but Attenuates Tubular Damage in Progressive Renal Injury
Pulskens, W. P. C., Rampanelli, E., Teske, G. J. D., Butter, L. M., Claessen, N., Luirink, I. K., van der Poll, T., Florquin, S., & Leemans, J. C. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009070722 · Cited by 155 · see citing works
Self-citationHwang, M., Matsumori, A., Furukawa, Y., Ono, K., Okada, M., Iwasaki, A., Hara, M., Miyamoto, T., Touma, M., & Sasayama, S. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01591-1 · Cited by 149 · see citing works
Shito, M., Wakabayashi, G., Ueda, M., Shimazu, M., Shirasugi, N., Endo, M., Mukai, M., & Kitajima, M. (1997) · Transplantation · doi:10.1097/00007890-199701150-00026 · Cited by 143 · see citing works
Targeting IL-1β in disease; the expanding role of NLRP3 inflammasome
Mitroulis, I., Skendros, P., & Ritis, K. (2010) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2010.03.005 · Cited by 131 · see citing works
Inflammasomes as microbial sensors
Franchi, L., Muñoz-Planillo, R., Reimer, T., Eigenbrod, T., & Núñez, G. (2010) · European Journal of Immunology · doi:10.1002/eji.200940180 · Cited by 121 · see citing works
Gene Silencing of NALP3 Protects Against Liver Ischemia–Reperfusion Injury in Mice
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Harada, H., Wakabayashi, G., Takayanagi, A., et al. (2002) · Transplantation · doi:10.1097/00007890-200211270-00016 · Cited by 49 · see citing works
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- [41]Kaczorowski DJ Tsung A Billiar TR Innate immune mechanisms in ischemia/reperfusion Front Biosci 2009 1 91 98 19482628
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“This protein complex contains an intracellular sensor, most often one of the Nod-like receptors (NLRs), which is a precursor of procaspase-1 and apopto-sis-associated speck-like protein containing a CARD (ASC) [15].”
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- Authors
- Leemans, J. C., Cassel, S. L., & Sutterwala, F. S.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- University of Iowa (US)
- Corresponding author
- Sutterwala, Fayyaz S.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2011-08-26
- Volume
- 243
- Issue
- 1
- Pages
- 152-162
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC3170135
- OpenAlex
- W2171212614
- Cited by
- 281
- References
- 99
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 5 · 2023: 14 · 2022: 15 · 2021: 13 · 2020: 14 · 2019: 27 · 2018: 26 · 2017: 17 · 2016: 30 · 2015: 34 · 2014: 22 · 2013: 24 · 2012: 16
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI087630, K08AI067736)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- NLRP3 inflammasome, inflammasome activation, caspase-1, IL-1β, IL-18, metabolic stress, infection, inflammatory diseases, pathogenesis
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Autoimmune Diseases, Carrier Proteins, Humans, Immunity, Innate, Infections, Inflammation, Stress, Physiological, Caspases, Interleukin-18, Interleukin-1beta, Inflammasomes
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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