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Cited by 473

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Demineralized bone matrix in bone repair: History and use

Open access
Gruskin, Elliott, Doll, Bruce A., Futrell, F. William, Schmitz, John P., Hollinger, Jeffrey O.·2012·Advanced Drug Delivery Reviews
DOI 10.1016/j.addr.2012.06.008
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Abstract

Demineralized bone matrix (DBM) is an osteoconductive and osteoinductive commercial biomaterial and approved medical device used in bone defects with a long track record of clinical use in diverse forms. True to its name and as an acid-extracted organic matrix from human bone sources, DBM retains much of the proteinaceous components native to bone, with small amounts of calcium-based solids, inorganic phosphates and some trace cell debris. Many of DBM's proteinaceous components (e.g., growth factors) are known to be potent osteogenic agents. Commercially sourced as putty, paste, sheets and flexible pieces, DBM provides a degradable matrix facilitating endogenous release of these compounds to the bone wound sites where it is surgically placed to fill bone defects, inducing new bone formation and accelerating healing. Given DBM's long clinical track record and commercial accessibility in standard forms and sources, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopedic repair and regenerative medicine contexts are attractive.

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Metadata

Authors
Gruskin, E., Doll, B. A., Futrell, F. W., Schmitz, J. P., & Hollinger, J. O.
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2012-09
Volume
64
Issue
12
Pages
1063-1077
ISSN
0169-409X (ISSN-L)
DOI
10.1016/j.addr.2012.06.008
OpenAlex
W1986138379
Cited by
473
References
46
FWCI
2.02
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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