ECM and ECM-like materials — Biomaterials for applications in regenerative medicine and cancer therapy
Open accessAbstract
Regenerative strategies such as stem cell-based therapies and tissue engineering applications are being developed with the aim to replace, remodel, regenerate or support damaged tissues and organs. In addition to careful cell type selection, the design of appropriate three-dimensional (3D) scaffolds is essential for the generation of bio-inspired replacement tissues. Such scaffolds are usually made of degradable or non-degradable biomaterials and can serve as cell or drug carriers. The development of more effective and efficient drug carrier systems is also highly relevant for novel cancer treatment strategies. In this review, we provide a summary of current approaches that employ ECM and ECM-like materials, or ECM-synthetic polymer hybrids, as biomaterials in the field of regenerative medicine. We further discuss the utilization of such materials for cell and drug delivery, and highlight strategies for their use as vehicles for cancer therapy.
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dECM contains an abundance of tissue-specific growth factors and signaling molecules, which play a pivotal role in the development of the cellular microenvironment niche.
“Decellularized extracellular matrix (dECM) contains an abundance of tissue‐specific growth factors and signaling molecules, which play a pivotal role in the development of the cellular microenvironment niche”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [12]
Cites
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PCL and PCL-based materials in biomedical applications
Malikmammadov, E., Tanir, T. E., Kiziltay, A., Hasirci, V., & Hasirci, N. (2018) · Journal of Biomaterials Science, Polymer Edition · doi:10.1080/09205063.2017.1394711 · Cited by 894 · see citing works
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- Authors
- Hinderer, S., Layland, S. L., & Schenke-Layland, K.
- Affiliations
- Fraunhofer Institute for Interfacial Engineering and Biotechnology (DE)
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 97
- Pages
- 260-269
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2181778634
- Cited by
- 469
- References
- 2
- Citations by year
- 2026: 22 · 2025: 41 · 2024: 54 · 2023: 46 · 2022: 41 · 2021: 54 · 2020: 69 · 2019: 45 · 2018: 50 · 2017: 34 · 2016: 13
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advanced Drug Delivery Reviews (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Funders
- Fraunhofer-Gesellschaft
- Eberhard Karls University Tübingen
- Fraunhofer IGB Stuttgart
- Ministry of Science, Research and the Arts of Baden-Württemberg (33-729.55-3/214, SI-BW 01222-91)
- Deutsche Forschungsgemeinschaft (SCHE 701/7-1)
- European Union (604531 AMCARE, FP7-NMP-2013-SME-7)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Keywords
- extracellular matrix, biomaterials, regenerative medicine, tissue engineering, 3D scaffolds, stem cell therapy, cell delivery, drug delivery, cancer therapy, drug carriers
- MeSH terms
- Animals, Biocompatible Materials, Extracellular Matrix, Humans, Neoplasms, Drug Delivery Systems, Tissue Engineering, Regenerative Medicine
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