PCL and PCL-based materials in biomedical applications

Malikmammadov, Elbay; Tanir, Tugba Endogan; Kiziltay, Aysel; Hasirci, Vasif; Hasirci, Nesrin

doi:10.1080/09205063.2017.1394711

Cited by 894biodegradable polymer synthesis and propertiesBone Tissue Engineering MaterialsSurgical Sutures and Adhesives

PCL and PCL-based materials in biomedical applications

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Malikmammadov, Elbay, Tanir, Tugba Endogan, Kiziltay, Aysel, Hasirci, Vasif, Hasirci, Nesrin·2018·Journal of Biomaterials Science, Polymer Edition

DOI 10.1080/09205063.2017.1394711

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Abstract

Biodegradable polymers have met with an increasing demand in medical usage over the last decades. One of such polymers is poly(ε-caprolactone) (PCL), which is a polyester that has been widely used in tissue engineering field for its availability, relatively inexpensive price and suitability for modification. Its chemical and biological properties, physicochemical state, degradability and mechanical strength can be adjusted, and therefore, it can be used under harsh mechanical, physical and chemical conditions without significant loss of its properties. Degradation time of PCL is quite long, thus it is used mainly in the replacement of hard tissues in the body where healing also takes an extended period of time. It is also used at load-bearing tissues of the body by enhancing its stiffness. However, due to its tailorability, use of PCL is not restricted to one type of tissue and it can be extended to engineering of soft tissues by decreasing its molecular weight and degradation time. This review outlines the basic properties of PCL, its composites, blends and copolymers. We report on various techniques for the production of different forms, and provide examples of medical applications such as tissue engineering and drug delivery systems covering the studies performed in the last decades.

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Authors: Malikmammadov, E., Tanir, T. E., Kiziltay, A., Hasirci, V., & Hasirci, N.
Affiliations: Middle East Technical University (TR)
BIOMATEN, Center of Excellence in Biomaterials and Tissue Engineering, Middle East Technical University, Ankara, Turkey
ORCID: Malikmammadov, Elbay
Venue: Journal of Biomaterials Science, Polymer Edition
Publisher: Informa UK Limited
Published: 2017-11-02
Volume: 29
Issue: 7-9
Pages: 863-893
ISSN: 0920-5063 (ISSN-L)
1568-5624
DOI: 10.1080/09205063.2017.1394711
OpenAlex: W2766867055
Cited by: 894
References: 183
Citations by year: 2026: 80 · 2025: 127 · 2024: 136 · 2023: 112 · 2022: 129 · 2021: 123 · 2020: 103 · 2019: 50 · 2018: 33
FWCI: 18.25
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
Locations: Journal of Biomaterials Science Polymer Edition (publishedVersion)
PubMed (publishedVersion)
OpenMETU (Middle East Technical University) (submittedVersion, cc-by-nc-nd)
Funders: Türkiye Bilimsel ve Teknolojik Araştirma Kurumu (213M708)
Topics: Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
Keywords: polycaprolactone, biodegradable polymers, tissue engineering, drug delivery systems, polymer blends, copolymers, polymer degradation, mechanical properties, soft tissue engineering, hard tissue replacement
MeSH terms: Biocompatible Materials, Drug Carriers, Electricity, Humans, Microspheres, Polyesters, Tissue Engineering

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