The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
New agents for the treatment of drug-resistant Mycobacterium tuberculosis
Open accessAbstract
Inadequate dosing and incomplete treatment regimens, coupled with the ability of the tuberculosis bacilli to cause latent infections that are tolerant of currently used drugs, have fueled the rise of multidrug-resistant tuberculosis (MDR-TB). Treatment of MDR-TB infections is a major clinical challenge that has few viable or effective solutions; therefore patients face a poor prognosis and years of treatment. This review focuses on emerging drug classes that have the potential for treating MDR-TB and highlights their particular strengths as leads including their mode of action, in vivo efficacy, and key medicinal chemistry properties. Examples include the newly approved drugs bedaquiline and delaminid, and other agents in clinical and late preclinical development pipeline for the treatment of MDR-TB. Herein, we discuss the challenges to developing drugs to treat tuberculosis and how the field has adapted to these difficulties, with an emphasis on drug discovery approaches that might produce more effective agents and treatment regimens.
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Cites
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
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Drug-like properties and the causes of poor solubility and poor permeability
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A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
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“Through the growth of drug-resistant mutants, it was discovered that the rotor ring of the organism's F0F1 ATP synthase was the target, specifically binding to the c subunit [25].”
BackgroundDrug-target residence time and its implications for lead optimization
Copeland, R. A., Pompliano, D. L., & Meek, T. D. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2082 · Cited by 1,464
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
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Advances in the development of new tuberculosis drugs and treatment regimens
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The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis
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Pharmacokinetic Interactions with Rifampicin: Clinical Relevance
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Cited by
(2023) · doi:10.1002/prot.26504 · Cited by 2
Metadata
- Authors
- Hoagland, D. T., Liu, J., Lee, R. B., & Lee, R. E.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 102
- Pages
- 55-72
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2405245899
- Cited by
- 328
- References
- 114
- FWCI
- 8.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hoagland, D. T., Liu, J., Lee, R. B., & Lee, R. E. (2016). New agents for the treatment of drug-resistant Mycobacterium tuberculosis. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2016.04.026
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
