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Cited by 1,025

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Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans

Open access
Comas, Iñaki, Coscolla, Mireia, Luo, Tao, Borrell, Sonia, Holt, Kathryn E, Kato-Maeda, Midori, Parkhill, Julian, Malla, Bijaya, Berg, Stefan, Thwaites, Guy, Yeboah-Manu, Dorothy, Bothamley, Graham, Mei, Jian, Wei, Lanhai, Bentley, Stephen, Harris, Simon R, Niemann, Stefan, Diel, Roland, Aseffa, Abraham, Gao, Qian, Young, Douglas, Gagneux, Sebastien·2013·Nature Genetics

Abstract

Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other crowd diseases, the origin of human tuberculosis has been associated with the Neolithic Demographic Transition, but recent studies point to a much earlier origin. We analyzed the whole genomes of 259 M. tuberculosis complex (MTBC) strains and used this data set to characterize global diversity and to reconstruct the evolutionary history of this pathogen. Coalescent analyses indicate that MTBC emerged about 70,000 years ago, accompanied migrations of anatomically modern humans out of Africa and expanded as a consequence of increases in human population density during the Neolithic period. This long coevolutionary history is consistent with MTBC displaying characteristics indicative of adaptation to both low and high host densities.

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Metadata

Authors
Comas, I., Coscolla, M., Luo, T., Borrell, S., Holt, K. E., Kato-Maeda, M., Parkhill, J., Malla, B., Berg, S., Thwaites, G., Yeboah-Manu, D., Bothamley, G., Mei, J., Wei, L., Bentley, S., Harris, S. R., Niemann, S., Diel, R., Aseffa, A., Gao, Q., Young, D., & Gagneux, S.
Venue
Nature Genetics
Published
2013-09-01
Volume
45
Issue
10
Pages
1176-1182
ISSN
  • 1061-4036 (ISSN-L)
  • 1546-1718
OpenAlex
W2105341822
Cited by
1,025
References
8
FWCI
60.81
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. https://app.cochat.ai/papers/10.1038/ng.2744
The paper
Comas, I., Coscolla, M., Luo, T., Borrell, S., Holt, K. E., Kato-Maeda, M., Parkhill, J., Malla, B., Berg, S., Thwaites, G., Yeboah-Manu, D., Bothamley, G., Mei, J., Wei, L., Bentley, S., Harris, S. R., Niemann, S., Diel, R., Aseffa, A., . . . Gagneux, S. (2013). Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans. Nature Genetics. https://doi.org/10.1038/ng.2744

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.