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Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery
Open accessAbstract
Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.
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Extracellular matrix and its therapeutic potential for cancer treatment
Huang, J., Zhang, L., Wan, D., Zhou, L., Zheng, S., Lin, S., & Qiao, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00544-0 · Cited by 962
Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases
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Experimental models and methods for cutaneous wound healing assessment
Masson‐Meyers, D. S., Andrade, T. A. M., Caetano, G. F., Guimaraes, F. R., Leite, M. N., Leite, S. N., & Frade, M. A. C. (2020) · International Journal of Experimental Pathology · doi:10.1111/iep.12346 · Cited by 531
The extracellular matrix as a multitasking player in disease
Theocharis, A. D., Manou, D., & Karamanos, N. K. (2019) · The FEBS Journal · doi:10.1111/febs.14818 · Cited by 511
The fibrogenic niche in kidney fibrosis: components and mechanisms
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Metadata
- Authors
- Schnittert, J., Bansal, R., Storm, G., & Prakash, J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 129
- Pages
- 37-53
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2792807159
- Cited by
- 188
- References
- 16
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schnittert, J., Bansal, R., Storm, G., & Prakash, J. (2018). Integrins in wound healing, fibrosis and tumor stroma: High potential targets for therapeutics and drug delivery. Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2018.01.020
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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