The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Articular fibrocartilage - Why does hyaline cartilage fail to repair?
Open accessAbstract
Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded versus naïve cells may explain one of the biggest discrepancies in mesenchymal stromal/stem cell (MSC) based cartilage regeneration. Namely, studies utilizing monolayer expanded MSCs, as indicated by numerous in vitro studies, report as a main limitation the induction of type X collagen and hypertrophy, a phenotype associated with endochondral bone formation. However, marrow stimulation and transfer studies report a mechanically inferior collagen I/II fibrocartilage as the main outcome. Therefore, this review will highlight the collagen species produced during the different therapeutic approaches. New developments in scaffold design and delivery of therapeutic molecules will be described. Potential future directions towards clinical translation will be discussed. New delivery mechanisms are being developed and they offer new hope in targeted therapeutic delivery.
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1 retracted
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Extracellular vesicles: Exosomes, microvesicles, and friends
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Treatment of Deep Cartilage Defects in the Knee with Autologous Chondrocyte Transplantation
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Cited by
The immune microenvironment in cartilage injury and repair
Li, M., Yin, H., Yan, Z., Li, H., Wu, J., Wang, Y., Wei, F., Tian, G., Ning, C., Li, H., et al. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.12.006 · Cited by 403
Platelet-rich plasma treatment for talar cartilage repair: a systematic review and meta-analysis
Peng, J., Wang, Q., Xu, Y., & He, H. (2023) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-023-06466-y · Cited by 13
Metadata
- Authors
- Armiento, A. R., Alini, M., & Stoddart, M. J.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 146
- Pages
- 289-305
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2907760167
- Cited by
- 408
- References
- 194
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Armiento, A. R., Alini, M., & Stoddart, M. J. (2019). Articular fibrocartilage - Why does hyaline cartilage fail to repair? Advanced Drug Delivery Reviews. https://doi.org/10.1016/j.addr.2018.12.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
