Overcoming barriers by local drug delivery with liposomes
Abstract
Localized or topical administration of drugs may be considered as a potential approach for overcoming the problems caused by the various biological barriers encountered in drug delivery. The combination of using localized administration routes and delivering drugs in nanoparticulate formulations, such as liposomes, may have additional advantages. Such advantages include prolonged retention of high drug loads at the site of action and controlled release of the drug, ensuring prolonged therapeutic effect; decreased potential for side-effects and toxicity (due to the high topical concentrations of drugs); and increased protection of drugs from possible harsh environments at the site of action. The use of targeted liposomal formulations may further potentiate any acquired therapeutic advantages. In this review we present the most advanced cases of localized delivery of liposomal formulations of drugs, which have been investigated pre-clinically and clinically in the last ten years, together with the reported therapeutic advantages, in each case.
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Brain-targeted delivery of liposomes can be enhanced by modification of targeting ligands including polymers, peptides, antibodies, and aptamers.
“Brain-targeted delivery of the liposomes could be enhanced by modification of targeting ligands including polymers, peptides, antibodies, and aptamers.”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [252]
Cites
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Sleep promotes branch-specific formation of dendritic spines after learning
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906 · see citing works
“252 For example, Zhan et al. functionalized liposomal surface with amyloid-β -derived peptide which has a highly speci fi c binding af fi nity towards plasm apolipoproteins, giving a protein corona-modi fi ed liposomal system.”
BackgroundVerma, S., Goand, U. K., Husain, A., Katekar, R. A., Garg, R., & Gayen, J. R. (2021) · Drug Development Research · doi:10.1002/ddr.21832 · Cited by 151 · see citing works
Nanocarrier system: An emerging strategy for bioactive peptide delivery
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- Authors
- Antimisiaris, S. G., Marazioti, A., Kannavou, M., Natsaridis, E., Gkartziou, F., Kogkos, G., & Mourtas, S.
- Affiliations
- University of Patras (GR)
- Foundation for Research and Technology Hellas (GR)
- Corresponding author
- Antimisiaris, S.G.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 174
- Pages
- 53-86
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W3128077304
- Cited by
- 339
- References
- 4
- Citations by year
- 2026: 38 · 2025: 59 · 2024: 88 · 2023: 62 · 2022: 66 · 2021: 26
- FWCI
- 5.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Regional Development Fund (5031792)
- European Commission
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- liposomes, local drug delivery, topical administration, biological barriers, nanoparticle drug delivery, controlled drug release
- MeSH terms
- Administration, Intranasal, Administration, Intravaginal, Administration, Topical, Animals, Drug Carriers, Humans, Liposomes, Drug Delivery Systems, Nanoparticles, Injections, Intraocular
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