The DOI matches its Crossref record; 329 of the 329 references it cites were found in a registry or an index.
Nucleic acid delivery for therapeutic applications
Abstract
Recent medical advances have exploited the ability to address a given disease at the underlying level of transcription and translation. These treatment paradigms utilize nucleic acids - including short interfering RNA (siRNA), microRNA (miRNA), antisense oligonucleotides (ASO), and messenger RNA (mRNA) - to achieve a desired outcome ranging from gene knockdown to induced expression of a selected target protein. Towards this end, numerous strategies for encapsulation or stabilization of various nucleic acid structures have been developed in order to achieve intracellular delivery. In this review, we discuss several therapeutic applications of nucleic acids directed towards specific diseases and tissues of interest, in particular highlighting recent technologies which have reached late-stage clinical trials and received FDA approval.
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Metadata
- Authors
- Gupta, A., Andresen, J. L., Manan, R. S., & Langer, R.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 178
- Pages
- 113834
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W3196815974
- Cited by
- 331
- References
- 329
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- closed
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