Drug delivery for metabolism targeted cancer immunotherapy
Open accessAbstract
Drug delivery vehicles have made a great impact on cancer immunotherapies in clinics and pre-clinical research. Notably, the science of delivery of cancer vaccines and immunotherapeutics, modulating immune cell functions has inspired development of several successful companies and clinical products. Interestingly, these drug delivery modalities not only modulate the function of immune cells (often quantified at the mRNA and protein levels), but also modulate the metabolism of these cells. Specifically, cancer immunotherapy often leads to activation of different immune cells such as dendritic cells, macrophages and T cells, which is driven by energy metabolism of these cells. Recently, there has been a great excitement about interventions that can directly modulate the energy metabolism of these immune cells and thus affect their function and in turn lead to a robust cancer immune response. Here we review few strategies that have been tested in clinic and pre-clinical research for generating effective metabolism-associated cancer therapies and immunotherapies.
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Uneven distribution often culminates in inadequate drug concentrations at the tumor site, reducing the drug's potential to effectively inhibit tumor growth.
“Such uneven distribution often culminates in inadequate drug concentrations at the tumor site, thereby reducing the drug’s potential to effectively inhibit tumor growth.346”
From Drug repurposing for cancer therapy (2024) · cites this paper as [346]
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Drug repurposing for cancer therapy
Xia, Y., Sun, M., Huang, H., & Jin, W.-L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01808-1 · Cited by 443 · see citing works
“346 Thus, it is crucial to devise the right therapeutic strategies to enhance their impact on tumor growth, while minimizing side effects and drug resistance.”
Background
- Authors
- Khodaei, T., Inamdar, S., Suresh, A. P., & Acharya, A. P.
- Affiliations
- Arizona State University (US)
- Corresponding author
- Acharya, Abhinav P.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 184
- Pages
- 114242
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W4220665865
- Cited by
- 30
- References
- 11
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 10 · 2023: 6 · 2022: 5
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 338 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Advanced Drug Delivery Reviews (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- drug carriers, cancer immunotherapy, immune cell metabolism, energy metabolism, cancer vaccines, dendritic cells, macrophages, T cells, immune cell activation
- MeSH terms
- Humans, Immunotherapy, Neoplasms, T-Lymphocytes, Drug Delivery Systems, Cancer Vaccines
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