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Quantitative SWATH-Based Proteomic Profiling for Identification of Mechanism-Driven Diagnostic Biomarkers Conferring in the Progression of Metastatic Prostate Cancer

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Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer

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Assessment of the low inhibitory specificity of oxamate, aminooxyacetate and dichloroacetate on cancer energy metabolism

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Polo-like kinase 1 (Plk1) inhibition synergizes with taxanes in triple negative breast cancer

Giordano, A., Liu, Y., Armeson, K. E., Park, Y., Ridinger, M., Erlander, M. G., Reuben, J. M., Britten, C. D., Kappler, C. S., Yeh, E. S., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224420 · Cited by 43 · see citing works

Immunometabolic cues recompose and reprogram the microenvironment around implanted biomaterials

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Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis

Sharma, S., Agnihotri, N., & Kumar, S. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114943 · Cited by 42 · see citing works

Ginsenoside CK induces apoptosis in triple-negative breast cancer cells by targeting glutamine metabolism

Zhang, B., Fu, R., Duan, Z., Shen, S., Zhu, C., & Fan, D. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115101 · Cited by 41 · see citing works

Exploiting the Achilles' heel of cancer: disrupting glutamine metabolism for effective cancer treatment

Fan, Y., Xue, H., Li, Z., Huo, M., Gao, H., & Guan, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1345522 · Cited by 40 · see citing works

SLC7A11 as a bridge between ferroptosis and disulfidptosis: a promising target for tumor treatment

Qiu, H., Liu, J., Shao, N., Zhao, J., Chen, C., Jiang, Y., Zhao, X., & Xu, L. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02447-x · Cited by 38 · see citing works

MYC, Metabolic Synthetic Lethality, and Cancer

Hsieh, A. L., & Dang, C. V. (2016) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-319-42118-6_4 · Cited by 36 · see citing works

Metabolic Imaging to Assess Treatment Response to Cytotoxic and Cytostatic Agents

Serkova, N. J., & Eckhardt, S. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00152 · Cited by 36 · see citing works

Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review

Wang, D., & Wan, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113923 · Cited by 34 · see citing works

Warburg and Krebs and related effects in cancer

Unterlass, J. E., & Curtin, N. J. (2019) · Expert Reviews in Molecular Medicine · doi:10.1017/erm.2019.4 · Cited by 35 · see citing works

Nf1 loss promotes Kras-driven lung adenocarcinoma and results in Psat1-mediated glutamate dependence

Wang, X., Min, S., Liu, H., Wu, N., Liu, X., Wang, T., Li, W., Shen, Y., Wang, H., Qian, Z., et al. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201809856 · Cited by 33 · see citing works

Glutamic-Pyruvic Transaminase 1 Facilitates Alternative Fuels for Hepatocellular Carcinoma Growth—A Small Molecule Inhibitor, Berberine

Guo, W., Tan, H., Li, S., Wang, N., & Feng, Y. (2020) · Cancers · doi:10.3390/cancers12071854 · Cited by 33 · see citing works

l -Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1

Liu, A., Lin, L., Xu, W., Gong, Z., Liu, Z., & Xiao, W. (2021) · Food & Function · doi:10.1039/d1fo00505g · Cited by 33 · see citing works

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells

Mauro-Lizcano, M., & López‐Rivas, A. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0263-0 · Cited by 33 · see citing works

Targeting Serine in Cancer: Is Two Better Than One?

Buqué, A., Galluzzi, L., & Montrose, D. C. (2021) · Trends in cancer · doi:10.1016/j.trecan.2021.06.004 · Cited by 32 · see citing works

Synthetic lethality: a step forward for personalized medicine in cancer

Jariyal, H., Weinberg, F. D., Achreja, A., Nagarath, D., & Srivastava, A. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.11.014 · Cited by 30 · see citing works

Inducing disulfidptosis in tumors:potential pathways and significance

Mi, T., Kong, X., Chen, M., Guo, P., & He, D. (2024) · MedComm · doi:10.1002/mco2.791 · Cited by 30 · see citing works

Abrogating GPT2 in triple‐negative breast cancer inhibits tumor growth and promotes autophagy

Mitra, D., Vega-Rubín-de-Celis, S., Royla, N., Bernhardt, S., Wilhelm, H., Tarade, N., Poschet, G., Buettner, M., Binenbaum, I., Borgoni, S., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33456 · Cited by 30 · see citing works

Drug delivery for metabolism targeted cancer immunotherapy

Khodaei, T., Inamdar, S., Suresh, A. P., & Acharya, A. P. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114242 · Cited by 30 · see citing works

The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells

Kleszcz, R., Paluszczak, J., Krajka‐Kuźniak, V., & Baer‐Dubowska, W. (2018) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/68979 · Cited by 29 · see citing works

Evaluation of a tyrosine kinase peptide microarray for tyrosine kinase inhibitor therapy selection in cancer

Labots, M., Gotink, K. J., Dekker, H., Azijli, K., van der Mijn, J. C., Huijts, C. M., Piersma, S. R., Jiménez, C. R., & Verheul, H. M. W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.114 · Cited by 28 · see citing works

Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases

Cao, Y., & Wang, R.-H. (2017) · Aging and Disease · doi:10.14336/ad.2016.1101 · Cited by 28 · see citing works

Glutamate dehydrogenase 1 mediated glutaminolysis sustains HCC cells survival under glucose deprivation

Zhou, Y.-J., Yu, H., Cheng, S., Chen, Y., He, L., Ren, J., He, X. Q., Chen, J., Zheng, L., Li, F., et al. (2022) · Journal of Cancer · doi:10.7150/jca.64195 · Cited by 28 · see citing works

Oncogenic Pathways in Neurodegenerative Diseases

Varela, L., & García-Rendueles, M. E. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063223 · Cited by 29 · see citing works

UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling

Cao, Y., Yan, X., Bai, X., Tang, F. R., Si, P., Bai, C., Tuoheti, K., Guo, L., Yisha, Z., Liu, T., et al. (2022) · Cancers · doi:10.3390/cancers14225538 · Cited by 28 · see citing works

Unraveling MYC’s Role in Orchestrating Tumor Intrinsic and Tumor Microenvironment Interactions Driving Tumorigenesis and Drug Resistance

Doha, Z. O., & Sears, R. C. (2023) · Pathophysiology · doi:10.3390/pathophysiology30030031 · Cited by 26 · see citing works

Inhibition of GOT1 sensitizes colorectal cancer cells to 5-fluorouracil

Hong, C., Zheng, J., & Li, X. (2017) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-017-3282-0 · Cited by 27 · see citing works

Regulating the proinflammatory response to composite biomaterials by targeting immunometabolism

Maduka, C. V., Makela, A. V., Tundo, A., Ural, E. E., Stivers, K. B., Kuhnert, M. M., Alhaj, M., Apu, E. H., Ashammakhi, N. A., Hankenson, K. D., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.046 · Cited by 26 · see citing works

Chick chorioallantoic membrane (CAM) assay for the evaluation of the antitumor and antimetastatic activity of platinum-based drugs in association with the impact on the amino acid metabolism

Mitrevska, K., Rodrigo, M. Á. M., Cernei, N., Michalkova, H., Šplíchal, Z., Hynek, D., Zítka, O., Heger, Z., Kopel, P., Adam, V., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100570 · Cited by 26 · see citing works

The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension

Bertero, T., Perk, D., & Chan, S. Y. (2019) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1615438 · Cited by 26 · see citing works

From Prokaryotes to Cancer: Glutamine Flux in Multicellular Units

Erez, A., & Kolodkin‐Gal, I. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.05.007 · Cited by 26 · see citing works

PET Imaging of 18F-(2S,4R)4-Fluoroglutamine Accumulation in Breast Cancer: From Xenografts to Patients

Liu, F., Xu, X., Zhu, H., Zhang, Y., Yang, J., Zhang, L., Li, N., Zhu, L., Kung, H. F., & Yang, Z. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00430 · Cited by 25 · see citing works

Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism

Punnasseril, J. M. J., Auwal, A., Gopalan, V., Lam, A. K.-Y., & Islam, F. (2025) · Cancer Medicine · doi:10.1002/cam4.71244 · Cited by 27 · see citing works

Glutamic oxaloacetic transaminase 1 as a potential target in human cancer

Song, Z., Yang, Y., Wu, Y., Zheng, M., Sun, D., Li, H., & Chen, L. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174754 · Cited by 24 · see citing works

Synergistic effect of antimetabolic and chemotherapy drugs in triple-negative breast cancer

López‐Camacho, E., Trilla‐Fuertes, L., Gámez‐Pozo, A., Dapía, I., López‐Vacas, R., Zapater‐Moros, A., Lumbreras-Herrera, M. I., Arias, P., Zamora, P. M., Vara, J. Á. F., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.112844 · Cited by 24 · see citing works

Insights into Metabolic Reprogramming in Tumor Evolution and Therapy

Chiu, C., Guerrero, J. J. G., Regalado, R. R. H., Zhou, J., Notarte, K. I., Lu, Y., Encarnacion, P. C., Carles, C., Octavo, E. M., Limbaroc, D. C. I., et al. (2024) · Cancers · doi:10.3390/cancers16203513 · Cited by 24 · see citing works

Glucose Favors Lipid Anabolic Metabolism in the Invasive Breast Cancer Cell Line MDA-MB-231

Ocaña, M. C., Martı́nez-Poveda, B., Quesada, A. R., & Medina, M. Á. (2020) · Biology · doi:10.3390/biology9010016 · Cited by 23 · see citing works

Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting

Pedersen, K. S., Gatto, F., Zerahn, B., Nielsen, J., Pedersen, B. K., Højman, P., & Gehl, J. (2020) · iScience · doi:10.1016/j.isci.2020.100978 · Cited by 23 · see citing works

Targeting androgen receptor-independent pathways in therapy-resistant prostate cancer

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Heterogeneity of glutamine metabolism in acquired-EGFR-TKI-resistant lung cancer

Kim, S., Jeon, J. S., Choi, Y. J., Baek, G. H., Kim, S. K., & Kang, K. W. (2022) · Life Sciences · doi:10.1016/j.lfs.2021.120274 · Cited by 22 · see citing works

Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells

Cimmino, T. P., Pagano, E., Stornaiuolo, M., Esposito, G., Ammendola, R., & Cattaneo, F. (2022) · Antioxidants · doi:10.3390/antiox11091692 · Cited by 21 · see citing works

Recent Advances in Targeting Tumor Energy Metabolism with Tumor Acidosis as a Biomarker of Drug Efficacy

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The role of GOT1 in cancer metabolism

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The landscape of tiered regulation of breast cancer cell metabolism

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Abstract P3-01-01: Targeting glutamine metabolism in breast cancer for therapy

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Abstract 4088: Targeting glutamine metabolism in breast cancer

Korangath, P. C., Zhang, H., Zhang, Z., Huso, D. L., Stearns, V., Dang, C. V., Semenza, G. L., & Sukumar, S. V. (2011) · Cancer Research · doi:10.1158/1538-7445.am2011-4088

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

Qing, G., Li, B., Vu, A., Skuli, N., Walton, Z. E., Liu, X., Mayes, P. A., Wise, D. R., Thompson, C. B., Maris, J. M., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.021 · Cited by 375 · see citing works

Abstract B75: Nutritional profiling reveals glutamine-utilizing transaminases as a metabolic vulnerability of TAZ/YAP-driven breast cancer cells

Stampouloglou, E., Kingston, N. M., Yang, C., Zhang, L., Monti, S., & Varelas, X. (2018) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1538-7755.disp17-b75

Abstract 1043: Targeting ASCT2-mediated glutamine uptake and metabolism in breast cancer

van Geldermalsen, M., Wang, Q., & Holst, J. (2016) · Cancer Research · doi:10.1158/1538-7445.am2016-1043