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Lipid nanoparticle-mediated drug delivery to the brain
Abstract
Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While LNPs have been extensively studied for the delivery of RNA drugs to muscle and liver targets, their potential to deliver drugs to challenging tissue targets such as the brain remains underexplored. Multiple brain disorders currently lack safe and effective therapies and therefore repurposing LNPs could potentially be a game changer for improving drug delivery to cellular targets both at and across the blood-brain barrier (BBB). In this review, we will discuss (1) the rationale and factors involved in optimizing LNPs for brain delivery, (2) ionic liquid-coated LNPs as a potential approach for increasing LNP accumulation in the brain tissue and (3) considerations, open questions and potential opportunities in the development of LNPs for delivery to the brain.
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“delivering LNPs across the blood–brain barrier (BBB) after systemic administration remains underexplored.”
From Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and Crossing (2024) · cites this paper as [27]
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Metadata
- Authors
- Khare, P., Edgecomb, S. X., Hamadani, C. M., Tanner, E. E. L., & S Manickam, D.
- Affiliations
- Duquesne University (US)
- University of Mississippi (US)
- Corresponding author
- Tanner, Eden E.L.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 197
- Pages
- 114861
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W4372198073
- Cited by
- 187
- References
- 260
- Citations by year
- 2026: 52 · 2025: 82 · 2024: 40 · 2023: 13
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Duquesne University
- Office of Research, University of Kansas
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- lipid nanoparticles, brain drug delivery, blood-brain barrier, ionic liquid coating
- MeSH terms
- COVID-19, Brain, Humans, Lipids, Liposomes, RNA, Small Interfering, Nanoparticles
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