Cited by 187Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryBarrier Structure and Function Studies

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Lipid nanoparticle-mediated drug delivery to the brain

Khare, Purva, Edgecomb, Sara X., Hamadani, Christine M., Tanner, Eden E.L., S Manickam, Devika·2023·Advanced Drug Delivery Reviews

DOI 10.1016/j.addr.2023.114861

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Abstract

Lipid nanoparticles (LNPs) have revolutionized the field of drug delivery through their applications in siRNA delivery to the liver (Onpattro) and their use in the Pfizer-BioNTech and Moderna COVID-19 mRNA vaccines. While LNPs have been extensively studied for the delivery of RNA drugs to muscle and liver targets, their potential to deliver drugs to challenging tissue targets such as the brain remains underexplored. Multiple brain disorders currently lack safe and effective therapies and therefore repurposing LNPs could potentially be a game changer for improving drug delivery to cellular targets both at and across the blood-brain barrier (BBB). In this review, we will discuss (1) the rationale and factors involved in optimizing LNPs for brain delivery, (2) ionic liquid-coated LNPs as a potential approach for increasing LNP accumulation in the brain tissue and (3) considerations, open questions and potential opportunities in the development of LNPs for delivery to the brain.

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Authors: Khare, P., Edgecomb, S. X., Hamadani, C. M., Tanner, E. E. L., & S Manickam, D.
Affiliations: Duquesne University (US)
University of Mississippi (US)
Corresponding author: Tanner, Eden E.L.
ORCID: Edgecomb, Sara X.
Hamadani, Christine M.
Tanner, Eden E.L.
Venue: Advanced Drug Delivery Reviews
Publisher: Elsevier BV
Published: 2023-06
Volume: 197
Pages: 114861
ISSN: 0169-409X (ISSN-L)
DOI: 10.1016/j.addr.2023.114861
OpenAlex: W4372198073
Cited by: 187
References: 260
Citations by year: 2026: 52 · 2025: 82 · 2024: 40 · 2023: 13
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Advanced Drug Delivery Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Duquesne University
Office of Research, University of Kansas
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: lipid nanoparticles, brain drug delivery, blood-brain barrier, ionic liquid coating
MeSH terms: COVID-19, Brain, Humans, Lipids, Liposomes, RNA, Small Interfering, Nanoparticles

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