Circadian clock genes and circadian phenotypes in patients with myocardial infarction
Abstract
Purpose Human physiological activities and diseases are under the control of the circadian rhythm. There are strong epidemiological associations between disrupted circadian rhythms, sleep duration and diseases. Sleep disorders are associated with vascular outcomes, such as myocardial infarction (MI). Methods We conducted an association study of genotype-phenotype interaction, to determine which circadian clock gene variants might be associated with the circadian phenotypes in patients with MI. In the present study, we analyzed the allele frequencies of 10 single nucleotide polymorphisms in four circadian clock genes in two independent samples: MI patients and controls. Chronotype was assessed using the Morningness - Eveningness Questionnaire (MEQ) and daytime sleepiness using the Epworth Sleepiness Scale (ESS). Results Chronotype was associated with the ARNTL genetic variant rs12363415 in MI patients. The polymorphisms rs11932595 of the CLOCK gene and rs934945 of the PER2 gene were associated with daytime sleepiness in the patient group. Conclusion Our data suggest that genetic variations in some circadian clock genes might be related to circadian phenotype (i.e., chronotype and daytime sleepiness) in patients with myocardial infarction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The assessment of chronotype categories through a questionnaire has been validated against CLOCK-gene based assessment of chronotype.
“there are several studies that validated the association of chronotype, and thus the assessment of chronotype categories through a questionnaire, with CLOCK-gene based assessed of chronotype [58].”
From Chronotype: A Tool to Screen Eating Habits in Polycystic Ovary Syndrome? (2022) · cites this paper as [58]
Cites
Epidemiology of the human circadian clock
Roenneberg, T., Kuehnle, T., Juda, M., Kantermann, T., Allebrandt, K., Gordijn, M., & Merrow, M. (2007) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.005 · Cited by 1,545 · see citing works
Thomas, M., Sing, H., Belenky, G., Holcomb, H., Mayberg, H., Dannals, R., Wagner JR., H., Thorne, D., Popp, K., Rowland, L., et al. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00225.x · Cited by 1,066 · see citing works
Jones, S. E., Tyrrell, J., Wood, A. R., Beaumont, R. N., Ruth, K. S., Tuke, M. A., Yaghootkar, H., Hu, Y., Teder-Laving, M., Hayward, C., et al. (2016) · PLOS Genetics · doi:10.1371/journal.pgen.1006125 · Cited by 388 · see citing works
Meng, L., Zheng, Y., & Hui, R. (2013) · Hypertension Research · doi:10.1038/hr.2013.70 · Cited by 370 · see citing works
Evening chronotype is associated with metabolic disorders and body composition in middle-aged adults
Yu, J. H., Yun, C.-H., Ahn, J. H., Suh, S., Cho, H. J., Lee, S. K., Yoo, H. J., Seo, J. A., Kim, S. G., Choi, K. M., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3754 · Cited by 358 · see citing works
Hu, Y., Shmygelska, A., Tran, D., Eriksson, N., Tung, J. Y., & Hinds, D. A. (2016) · Nature Communications · doi:10.1038/ncomms10448 · Cited by 321 · see citing works
Michael Vanderlind, W., Beevers, C. G., Sherman, S. M., Trujillo, L. T., McGeary, J. E., Matthews, M. D., Todd Maddox, W., & Schnyer, D. M. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.10.006 · Cited by 117 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chronotype: A Tool to Screen Eating Habits in Polycystic Ovary Syndrome?
Barrea, L., Verde, L., Vetrani, C., Savastano, S., Colao, A., & Muscogiuri, G. (2022) · Nutrients · doi:10.3390/nu14050955 · Cited by 20 · see citing works
“Although a CLOCK-gene assessment of chronotype should be more accurate but more difficult to carry out, there are several studies that validated the association of chronotype, and thus the assessment of chronotype categories through a questionnaire, with CLOCK-gene based assessed of chronotype [58].”
Method
- Authors
- Škrlec, I., Milić, J., Heffer, M., Wagner, J., & Peterlin, B.
- Affiliations
- University of Osijek (HR)
- Ljubljana University Medical Centre (SI)
- Corresponding author
- Škrlec, Ivana
- Venue
- Advances in Medical Sciences
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 64
- Issue
- 2
- Pages
- 224-229
- ISSN
- 0067-6489 (ISSN-L)
- 1896-1126
- OpenAlex
- W2917471890
- Cited by
- 27
- References
- 7
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 2
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Medical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Josip Juraj Strossmayer University of Osijek, Croatia (IZIP-2014-150)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- clock genes, myocardial infarction, chronotype, daytime sleepiness, single nucleotide polymorphisms, genotype-phenotype interaction, Bmal1, Per2, circadian rhythm disruption, sleep disorders
- MeSH terms
- Aged, Circadian Rhythm, Female, Humans, Male, Middle Aged, Phenotype, Surveys and Questionnaires, Polymorphism, Single Nucleotide, ARNTL Transcription Factors, Period Circadian Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
