Characteristics of platelet indices and their prognostic significance in selected medical condition – a systematic review
Open accessAbstract
BACKGROUND: Platelets, also called thrombocytes, are produced in bone marrow and are the second most numerous blood cells which circulate in blood and play a pivotal role in hemostasis, wound healing, angiogenesis. There is a large body of evidence that platelets are likely to contribute to inflammation in multiple diseases. Also, recent studies revealed the association between platelet indices (PI) and inflammation. METHODS: PubMed, Scopus and Google Scholar databases were searched and only papers published in the last 10 years were consequently analyzed. RESULTS: The most frequently evaluated parameters are mean platelet volume (MPV), platelet diversity index (PDW), plateletcrit (PCT) and the presence of larger platelets (P-LCRs platelet larger cell ratio). The values of platelet indices (PI) were elevated in patients suffering from type 2 diabetes mellitus, myocardial infarction, cancers or acute surgical conditions, such as appendicitis. The measurement of PIs does not generate additional costs and can be performed during routine cell blood count, not requiring additional blood samples. CONCLUSIONS: Platelet indices may have prognostic and predictive value in numerous conditions.
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Platelets play an important role in inflammatory response.
“Platelet played an important role in inflammatory response.23”
From Albumin and Associated Biomarkers in Severe Neuropsychiatric Disorders: Acute-Phase Schizophrenia and Bipolar Disorder (2023) · cites this paper as [23]
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The impact of platelet indices in the evaluation of different causes of platelet count disorder
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Differential Proneness to Obesity in Two Rat Strains with Diverse Immune Responses
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The Significance of Platelet Indices in the Evaluation of Thrombocytopenia
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The Impact of Bone Pain Crises on Platelet Parameters in Sample of Iraqi Sickle Cell Anemia Patients
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- Authors
- Pogorzelska, K., Krętowska, A., Krawczuk-Rybak, M., & Sawicka-Żukowska, M.
- Affiliations
- Medical University of Białystok (PL)
- Corresponding author
- Sawicka-Żukowska, Małgorzata
- Venue
- Advances in Medical Sciences
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 65
- Issue
- 2
- Pages
- 310-315
- ISSN
- 0067-6489 (ISSN-L)
- 1896-1126
- OpenAlex
- W3033427258
- Cited by
- 153
- References
- 51
- Citations by year
- 2026: 21 · 2025: 34 · 2024: 29 · 2023: 30 · 2022: 23 · 2021: 14 · 2020: 2
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advances in Medical Sciences (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Keywords
- platelet indices, mean platelet volume, plateletcrit, platelet distribution width, inflammation, prognostic factors, type 2 diabetes, myocardial infarction, cancer, appendicitis, hemostasis
- MeSH terms
- Animals, Blood Platelets, Disease, Humans, Inflammation, Platelet Count, Mean Platelet Volume
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