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Cited by 86Food composition and propertiesLipoproteins and Cardiovascular HealthMicrobial Metabolites in Food Biotechnology

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Soluble Fiber Supplementation and Serum Lipid Profile: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

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Ghavami, Abed, Ziaei, Rahele, Talebi, Sepide, Barghchi, Hanieh, Nattagh-Eshtivani, Elyas, Moradi, Sajjad, Rahbarinejad, Pegah, Mohammadi, Hamed, Ghasemi-Tehrani, Hatav, Marx, Wolfgang, Askari, Gholamreza·2023·Advances in Nutrition
DOI 10.1016/j.advnut.2023.01.005PMC PMC10201678
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Abstract

To present a comprehensive synthesis of the effect of soluble fiber supplementation on blood lipid parameters in adults, a systematic search was undertaken in PubMed, Scopus, and ISI Web of Science of relevant articles published before November 2021. Randomized controlled trials (RCTs) evaluating the effects of soluble fibers on blood lipids in adults were included. We estimated the change in blood lipids for each 5 g/d increment in soluble fiber supplementation in each trial and then calculated the mean difference (MD) and 95% CI using a random-effects model. We estimated dose-dependent effects using a dose-response meta-analysis of differences in means. The risk of bias and certainty of the evidence was evaluated using the Cochrane risk of bias tool and the Grading Recommendations Assessment, Development, and Evaluation methodology, respectively. A total of 181 RCTs with 220 treatment arms (14,505 participants: 7348 cases and 7157 controls) were included. There was a significant reduction in LDL cholesterol (MD: -8.28 mg/dL, 95% CI: -11.38, -5.18), total cholesterol (TC) (MD: -10.82 mg/dL, 95% CI: -12.98, -8.67), TGs (MD: -5.55 mg/dL, 95% CI: -10.31, -0.79), and apolipoprotein B (Apo-B) (MD: -44.99 mg/L, 95% CI: -62.87, -27.12) after soluble fiber supplementation in the overall analysis. Each 5 g/d increase in soluble fiber supplementation had a significant reduction in TC (MD: -6.11 mg/dL, 95% CI: -7.61, -4.61) and LDL cholesterol (MD: -5.57 mg/dl, 95% CI: -7.44, -3.69). In a large meta-analysis of RCTs, results suggest that soluble fiber supplementation could contribute to the management of dyslipidemia and the reduction of cardiovascular disease risk.

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  • A 5-10 g/day increase of soluble fiber is accompanied by a 5-6% decrease in LDL cholesterol in PCOS women at risk of cardiovascular complications.

    “The study observed that the 5–10 g/day increase of soluble fiber that was accompanied by a 5–6% decrease in LDL cholesterol was a significant change for PCOS women who, due to their conditioned lifestyle, are at risk of cardiovascular complications like having the heart arteries clogged and impaired blood flow to the heart muscles [131].”

    From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [131]

    The Results (Meta-analysis results; page not provided) report lower LDL cholesterol with soluble-fiber supplementation: 5.57 mg/dL per 5 g/day increment and 10.75 mg/dL at 10 g/day. The paper does not express these changes as a 5–6% decrease or establish the effect specifically in women with PCOS. (LLM, conf=0.91)

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Research works printed but not linked: 32

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Metadata

Authors
Ghavami, A., Ziaei, R., Talebi, S., Barghchi, H., Nattagh-Eshtivani, E., Moradi, S., Rahbarinejad, P., Mohammadi, H., Ghasemi-Tehrani, H., Marx, W., & Askari, G.
Affiliations
  • Isfahan University of Medical Sciences (IR)
  • Tehran University of Medical Sciences (IR)
  • Mashhad University of Medical Sciences (IR)
  • Kermanshah University of Medical Sciences (IR)
  • Barwon Health (AU)
Corresponding author
Askari, Gholamreza
ORCID
Venue
Advances in Nutrition
Publisher
Elsevier BV
Published
2023-05
Volume
14
Issue
3
Pages
465-474
ISSN
  • 2156-5376 (ISSN-L)
  • 2161-8313
DOI
10.1016/j.advnut.2023.01.005
PMC
PMC10201678
OpenAlex
W4318756733
Cited by
86
References
6
Citations by year
2026: 32 · 2025: 29 · 2024: 14 · 2023: 10
FWCI
3.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Advances in Nutrition (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
lipid profile, LDL cholesterol, total cholesterol, triglycerides, apolipoprotein B, dyslipidemia, cardiovascular risk, dose-response relationship, dietary fiber
MeSH terms
Adult, Humans, Lipids, Cholesterol, LDL, Randomized Controlled Trials as Topic, Dietary Supplements, Dyslipidemias

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