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Cited by 25Antioxidant Activity and Oxidative StressCardiac Valve Diseases and TreatmentsNitric Oxide and Endothelin Effects

Impact of vitamin E and C supplementation on serum adhesion molecules in chronic degenerative aortic stenosis: a randomized controlled trial

Tahir, Muhammad, Foley, Brendan, Pate, Gordon, Crean, Peter, Moore, David, McCarroll, Nuala, Walsh, Michael·2005·American Heart Journal
DOI 10.1016/j.ahj.2004.09.009
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Abstract

Background An inflammatory component has been identified in degenerative aortic stenosis (AS). The combination of vitamins E and C has been shown to have anti-inflammatory properties. The aim of this study was to determine the impact of the combination of vitamins C and E or vitamin C only on serum levels of cell adhesion molecules and C-reactive protein in patients with chronic degenerative AS, with or without concomitant coronary artery disease.Methods and results One hundred patients with asymptomatic or mildly symptomatic moderate AS were randomized in 2:2:1 format in an open-label trial. Forty-one patients received vitamin E (400 IU) and vitamin C (1000 mg) daily, 39 patients received vitamin C (1000 mg) only, and 20 patients were followed as controls. Serum intracellular adhesion molecule (ICAM-1), E selectin, P selectin, vascular-cellular adhesion molecule (VCAM-1), C-reactive protein, and alpha-tocopherol (vitamin E) were measured by enzyme-linked immunosorbent assay at baseline and 6 months postsupplementation. Half of the patients from each of the 2 active groups were followed for further 6 months to determine any changes after cessation of therapy. In the vitamin E and C, group there was reduction in serum ICAM-1 (298 +/- 12 to 272 +/- 12 ng/mL at 6 months, P = .0015) with a return to base line 6 months after cessation of therapy. In the vitamin C only group, there was a reduction in serum P selectin (134 +/- 10 to 118 +/- 10 ng/mL at 6 months, P = .033). All the inflammatory markers were unchanged in control group over 6 months of follow-up.Conclusion Vitamin E and C supplementation had modest anti-inflammatory effect in chronic degenerative AS. The clinical relevance of this would require further clarification.

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  • In elderly people, physical activity is inversely associated with inflammatory markers, independent of BMI, and the association is suggested to be dose-dependent.

    “Rather consistent inverse, BMI-independent, associations are found and the associations are suggested to be dosedependent; the more physically active the person, the lower the inflammatory markers (208,224) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [224]

  • Elderly people have higher basal levels of inflammation independently of disease status.

    “Elderly people have higher basal levels of inflammation independently of disease status, and a considerable number of studies have been carried out in this population to assess associations between physical activity and inflammatory markers (190,223 -230) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [224]

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Authors
Tahir, M., Foley, B., Pate, G., Crean, P., Moore, D., McCarroll, N., & Walsh, M.
Affiliations
St. James's Hospital (IE)
Corresponding author
Foley, Brendan
ORCID
Venue
American Heart Journal
Publisher
Elsevier BV
Published
2005-08
Volume
150
Issue
2
Pages
302-306
ISSN
0002-8703 (ISSN-L)
DOI
10.1016/j.ahj.2004.09.009
OpenAlex
W2164003330
Cited by
25
References
22
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2014: 1 · 2012: 2
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
vitamin E supplementation, vitamin C supplementation, calcific aortic stenosis, adhesion molecules, ICAM-1, P-selectin, E-selectin, VCAM-1, C-reactive protein, inflammation, coronary artery disease, alpha-tocopherol, anti-inflammatory activity
MeSH terms
Aged, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Aortic Valve Stenosis, Ascorbic Acid, C-Reactive Protein, Drug Therapy, Combination, Female, Humans, Inflammation, Male, Middle Aged, Vitamin E, Cell Adhesion Molecules, Treatment Outcome, Intercellular Adhesion Molecule-1, P-Selectin, Vascular Cell Adhesion Molecule-1, E-Selectin

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