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Cited by 160Heart Failure Treatment and ManagementCardiovascular Function and Risk FactorsDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: Findings from Get With The Guidelines-Heart Failure registry

Echouffo-Tcheugui, Justin B., Xu, Haolin, DeVore, Adam D., Schulte, Phillip J., Butler, Javed, Yancy, Clyde W., Bhatt, Deepak L., Hernandez, Adrian F., Heidenreich, Paul A., Fonarow, Gregg C.·2016·American Heart Journal
DOI 10.1016/j.ahj.2016.07.025
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Abstract

Background The contribution of diabetes to the burden of heart failure (HF) remains largely undescribed. Assessing diabetes temporal trends among US patients hospitalized with HF and their relation with quality measures in real-world practice can help to define this burden.Methods Using data from the Get With the Guidelines-Heart Failure registry, we assessed temporal trends in diabetes prevalence among patients with HF and in subgroups with reduced ejection fraction (HFrEF; EF < 40%), borderline EF (HFbEF; 40%≤EF <50%), or preserved EF (HFpEF; EF ≥ 50%), hospitalized between 2005 and 2015. Logistic regression was used to assess whether in-hospital outcomes and HF quality of care were related to trends.Results Among 364,480 HF hospitalizations, 160,171 had diabetes (44.0% overall, 41.8% in HFrEF, 46.7% in HFbEF, 45.5% in HFpEF). There was a temporal increase in diabetes frequency in HF patients (43.2%-45.8%; P trend <.0001), including among those with HFrEF (42.0%-43.6%; P trend <.0001), HFbEF (46.0%-49.2%; P trend <.0001), or HFpEF (43.6%-46.8%, P trend <.0001). Diabetic patients had a longer hospital stay (adjusted odds ratio 1.14, 95% CI 1.12-1.16), but lower in-hospital mortality (adjusted odds ratio 0.93 [0.89-0.97]) compared with those without diabetes, with limited differences in quality measures. Temporal trends in diabetes were not associated with in-hospital mortality or length of stay. There were no temporal interactions of most HF quality measures with diabetes status.Conclusions Approximately 44% of hospitalized HF patients have diabetes, and this proportion has been increasing over the past 10years, particularly among those patients with new-onset HFpEF.

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Authors
Echouffo-Tcheugui, J. B., Xu, H., DeVore, A. D., Schulte, P. J., Butler, J., Yancy, C. W., Bhatt, D. L., Hernandez, A. F., Heidenreich, P. A., & Fonarow, G. C.
Affiliations
  • Brigham and Women's Hospital (US)
  • Duke Clinical Research Institute (US)
  • Mayo Clinic (US)
  • Stony Brook University (US)
  • Northwestern University (US)
  • VA Palo Alto Health Care System (US)
  • University of California, Los Angeles (US)
Corresponding author
Echouffo-Tcheugui, Justin B.
ORCID
Venue
American Heart Journal
Publisher
Elsevier BV
Published
2016-12
Volume
182
Pages
9-20
ISSN
0002-8703 (ISSN-L)
DOI
10.1016/j.ahj.2016.07.025
OpenAlex
W2508250664
Cited by
160
References
41
Citations by year
2026: 7 · 2025: 12 · 2024: 24 · 2023: 16 · 2022: 28 · 2021: 21 · 2020: 22 · 2019: 13 · 2018: 11 · 2017: 5
FWCI
7.97
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of California, Los Angeles
  • Ahmanson Foundation
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
diabetes mellitus, heart failure, temporal trends, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, in-hospital mortality, length of hospital stay, quality of care, new-onset diabetes, hospitalized patients
MeSH terms
Aged, Aged, 80 and over, Diabetes Mellitus, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Registries, Socioeconomic Factors, Stroke Volume, United States, Comorbidity, Prevalence, Hospital Mortality

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