Temporal trends and factors associated with diabetes mellitus among patients hospitalized with heart failure: Findings from Get With The Guidelines-Heart Failure registry
Abstract
Background The contribution of diabetes to the burden of heart failure (HF) remains largely undescribed. Assessing diabetes temporal trends among US patients hospitalized with HF and their relation with quality measures in real-world practice can help to define this burden.Methods Using data from the Get With the Guidelines-Heart Failure registry, we assessed temporal trends in diabetes prevalence among patients with HF and in subgroups with reduced ejection fraction (HFrEF; EF < 40%), borderline EF (HFbEF; 40%≤EF <50%), or preserved EF (HFpEF; EF ≥ 50%), hospitalized between 2005 and 2015. Logistic regression was used to assess whether in-hospital outcomes and HF quality of care were related to trends.Results Among 364,480 HF hospitalizations, 160,171 had diabetes (44.0% overall, 41.8% in HFrEF, 46.7% in HFbEF, 45.5% in HFpEF). There was a temporal increase in diabetes frequency in HF patients (43.2%-45.8%; P trend <.0001), including among those with HFrEF (42.0%-43.6%; P trend <.0001), HFbEF (46.0%-49.2%; P trend <.0001), or HFpEF (43.6%-46.8%, P trend <.0001). Diabetic patients had a longer hospital stay (adjusted odds ratio 1.14, 95% CI 1.12-1.16), but lower in-hospital mortality (adjusted odds ratio 0.93 [0.89-0.97]) compared with those without diabetes, with limited differences in quality measures. Temporal trends in diabetes were not associated with in-hospital mortality or length of stay. There were no temporal interactions of most HF quality measures with diabetes status.Conclusions Approximately 44% of hospitalized HF patients have diabetes, and this proportion has been increasing over the past 10years, particularly among those patients with new-onset HFpEF.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Approximately 45% of people admitted for HFpEF have diabetes.
“Approximately 45% of people admitted for HFpEF have diabetes, and most people with HFpEF have obesity (320,321).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [320]
Most people with HFpEF have obesity.
“Approximately 45% of people admitted for HFpEF have diabetes, and most people with HFpEF have obesity (320,321).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025 (2025) · cites this paper as [320]
Most people with HFpEF have obesity.
“Increasing evidence has demonstrated the benefits of GLP-1 RA or dual GIP/GLP-1 RA on symptoms and outcomes for people with HFpEF and obesity, and while most people with HFpEF have obesity, approximately 45% have diabetes (304,305).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [304]
Increasing evidence has demonstrated benefits of GLP-1 RA or dual GIP/GLP-1 RA on symptoms and outcomes for people with HFpEF and obesity.
“Increasing evidence has demonstrated the benefits of GLP-1 RA or dual GIP/GLP-1 RA on symptoms and outcomes for people with HFpEF and obesity, and while most people with HFpEF have obesity, approximately 45% have diabetes (304,305).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [304]
Approximately 45% of people with HFpEF have diabetes.
“Increasing evidence has demonstrated the benefits of GLP-1 RA or dual GIP/GLP-1 RA on symptoms and outcomes for people with HFpEF and obesity, and while most people with HFpEF have obesity, approximately 45% have diabetes (304,305).”
From 10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026 (2026) · cites this paper as [304]
About 45% of people suffering from HFpEF have diabetes, with a significantly increasing proportion in those with new-onset HFpEF.
“In the past decade, HFpEF has taken on great importance in individuals with diabetes who represent about 45% of people suffering from this type of HF, with a significantly increasing proportion in those with new-onset HFpEF [73].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [73]
A slight increase in T2DM prevalence was reported in North America over time.
“and a slight increase in the prevalence was reported in North America over time.49,52”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [49]
In registries of hospitalized HF patients in North America and Europe, the prevalence of T2DM is around 40-45%.
“In registries of hospitalized HF patients in North America and Europe, the prevalence of T2DM is around 40-45%, 49 -52”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [49]
Cites
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works
2013 ACCF/AHA Guideline for the Management of Heart Failure
Yancy, C. W., Jessup, M., Bozkurt, B., Butler, J., Casey, D. E., Drazner, M. H., Fonarow, G. C., Geraci, S. A., Horwich, T., Januzzi, J. L., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.05.019 · Cited by 12,536 · see citing works
Self-citationEmpagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Zinman, B., Wanner, C., Lachin, J. M., Fitchett, D., Bluhmki, E., Hantel, S., Mattheus, M., Devins, T., Johansen, O. E., Woerle, H. J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504720 · Cited by 12,315 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595 · see citing works
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus
Scirica, B. M., Bhatt, D. L., Braunwald, E., Steg, P. G., Davidson, J., Hirshberg, B., Ohman, P., Frederich, R., Wiviott, S. D., Hoffman, E. B., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1307684 · Cited by 3,470 · see citing works
International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes
The International Expert Committee (2009) · Diabetes Care · doi:10.2337/dc09-9033 · Cited by 3,185 · see citing works
Forecasting the Impact of Heart Failure in the United States
Heidenreich, P. A., Albert, N. M., Allen, L. A., Bluemke, D. A., Butler, J., Fonarow, G. C., Ikonomidis, J. S., Khavjou, O., Konstam, M. A., Maddox, T. M., et al. (2013) · Circulation Heart Failure · doi:10.1161/hhf.0b013e318291329a · Cited by 2,802 · see citing works
ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs105 · Cited by 2,644 · see citing works
Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012
Menke, A., Casagrande, S., Geiss, L., & Cowie, C. C. (2015) · JAMA · doi:10.1001/jama.2015.10029 · Cited by 2,362 · see citing works
Economic Costs of Diabetes in the U.S. in 2012
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc12-2625 · Cited by 2,153 · see citing works
Boyle, J. P., Thompson, T. J., Gregg, E. W., Barker, L. E., & Williamson, D. F. (2010) · Population Health Metrics · doi:10.1186/1478-7954-8-29 · Cited by 1,309 · see citing works
Molecular mechanisms of diabetic cardiomyopathy
Bugger, H., & Abel, E. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3171-6 · Cited by 903 · see citing works
Braunstein, J. B., Anderson, G. F., Gerstenblith, G., Weller, W. E., Niefeld, M. R., Herbert, R. J., & Wu, A. W. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00947-1 · Cited by 778 · see citing works
Diabetic cardiomyopathy, causes and effects
Boudina, S., & Abel, E. D. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9131-7 · Cited by 730 · see citing works
Scirica, B. M., Braunwald, E., Raz, I., Cavender, M. A., Morrow, D. A., Jarolim, P., Udell, J. A., Mosenzon, O., Im, K., Umez-Eronini, A. A., et al. (2014) · Circulation · doi:10.1161/circulationaha.114.010389 · Cited by 725 · see citing works
Heart failure prevalence, incidence, and mortality in the elderly with diabetes
Bertoni, A. G., Hundley, W. G., Massing, M. W., Bonds, D. E., Burke, G. L., & Goff, D. C. (2004) · Diabetes Care · doi:10.2337/diacare.27.3.699 · Cited by 596 · see citing works
Cavender, M. A., Steg, P. G., Smith, S. C., Eagle, K., Ohman, E. M., Goto, S., Kuder, J., Im, K., Wilson, P. W. F., & Bhatt, D. L. (2015) · Circulation · doi:10.1161/circulationaha.114.014796 · Cited by 501 · see citing works
Self-citationTrends in Comorbidity, Disability, and Polypharmacy in Heart Failure
Wong, C. Y., Chaudhry, S. I., Desai, M. M., & Krumholz, H. M. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.08.017 · Cited by 319 · see citing works
Heart failure: a cardiovascular outcome in diabetes that can no longer be ignored
McMurray, J. J. V., Gerstein, H. C., Holman, R. R., & Pfeffer, M. A. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70031-2 · Cited by 303 · see citing works
International Expert Committee Report on the Role of the A1C Assay in the Diagnosis of Diabetes
Nathan, D. M. (2009) · Diabetes Care · doi:10.2337/dc09-1777 · Cited by 299 · see citing works
Diabetes in heart failure: prevalence and impact on outcome in the population
From, A. M., Leibson, C. L., Bursi, F., Redfield, M. M., Weston, S. A., Jacobsen, S. J., Rodeheffer, R. J., & Roger, V. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.05.024 · Cited by 295 · see citing works
The American Heart Association get with the guidelines program
Smaha, L. A. (2004) · American Heart Journal · doi:10.1016/j.ahj.2004.09.015 · Cited by 295 · see citing works
Suskin, N. (2000) · European Heart Journal · doi:10.1053/euhj.1999.2043 · Cited by 271 · see citing works
The Burden of Acute Heart Failure on U.S. Emergency Departments
Storrow, A. B., Jenkins, C. A., Self, W. H., Alexander, P. T., Barrett, T. W., Han, J. H., McNaughton, C. D., Heavrin, B. S., Gheorghiade, M., & Collins, S. P. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.01.006 · Cited by 256 · see citing works
Udell, J. A., Cavender, M. A., Bhatt, D. L., Chatterjee, S., Farkouh, M. E., & Scirica, B. M. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00044-3 · Cited by 254 · see citing works
Greenberg, B. H., Abraham, W. T., Albert, N. M., Chiswell, K., Clare, R., Stough, W. G., Gheorghiade, M., O'Connor, C. M., Sun, J. L., Yancy, C. W., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.05.001 · Cited by 196 · see citing works
Amato, L., Paolisso, G., Cacciatore, F., Ferrara, N., Ferrara, P., Canonico, S., Varricchio, M., & Rengo, F. (1997) · PubMed · Cited by 193 · see citing works
Dipeptidyl peptidase-4 inhibitors and heart failure: A meta-analysis of randomized clinical trials
Monami, M., Dicembrini, I., & Mannucci, E. (2014) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2014.01.017 · Cited by 191 · see citing works
Shah, A. D., Langenberg, C., Rapsomaniki, E., Denaxas, S., Pujades‐Rodríguez, M., Gale, C. P., Deanfield, J. E., Smeeth, L. L., Timmis, A., & Hemingway, H. (2015) · The Lancet · doi:10.1016/s0140-6736(15)60401-9 · Cited by 144 · see citing works
The Population Burden of Heart Failure Attributable to Modifiable Risk Factors
Avery, C. L., Loehr, L. R., Baggett, C. D., Chang, P. P., Kucharska‐Newton, A., Matsushita, K., Rosamond, W. D., & HEISS, G. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.022 · Cited by 105 · see citing works
Functional class in patients with heart failure is associated with the development of diabetes
Tenenbaum, A., Motro, M., Fisman, E. Z., Leor, J., Freimark, D., Boyko, V., Mandelzweig, L., Adler, Y., Sherer, Y., & Behar, S. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(02)01530-9 · Cited by 99 · see citing works
Diabetes and the Risk of Heart Failure
Dhingra, R., & Vasan, R. S. (2011) · Heart Failure Clinics · doi:10.1016/j.hfc.2011.08.008 · Cited by 76 · see citing works
Sud, M. K., Wang, X., Austin, P. C., Lipscombe, L. L., Newton, G. E., Tu, J. V., Vasan, R. S., & Lee, D. S. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehu462 · Cited by 70 · see citing works
Dunbar, S. B., Reilly, C. M., GARY, R. A., Higgins, M. K., Culler, S. D., Butts, B., & Butler, J. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.05.012 · Cited by 69 · see citing works
Blecker, S., Ladapo, J. A., Doran, K. M., Goldfeld, K. S., & Katz, S. D. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.08.002 · Cited by 69 · see citing works
The Human Side of Diabetes Care
Fonseca, V. A. (2008) · Diabetes Care · doi:10.2337/dc08-1873 · Cited by 66 · see citing works
Comorbid Diabetes and End-of-Life Expenditures Among Medicare Beneficiaries With Heart Failure
Blecker, S., Herbert, R. J., & Brancati, F. L. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.09.011 · Cited by 28 · see citing works
Diabetes, quality of care, and in-hospital outcomes in patients hospitalized with heart failure
Kapoor, J. R., Fonarow, G. C., Zhao, X., Kapoor, R., Hernandez, A. F., & Heidenreich, P. A. (2011) · American Heart Journal · doi:10.1016/j.ahj.2011.06.008 · Cited by 26 · see citing works
Self-citationAn Economic Evaluation of a Self-Care Intervention in Persons With Heart Failure and Diabetes
Reilly, C. M., Butler, J., Culler, S. D., GARY, R. A., Higgins, M. K., Schindler, P., Butts, B., & Dunbar, S. B. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.06.382 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 41 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Maddox, T. M., Januzzi, J. L., Allen, L. A., Breathett, K. K., Butler, J., Davis, L. L., Fonarow, G. C., Ibrahim, N. E., Lindenfeld, J., Masoudi, F. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.11.022 · Cited by 857 · see citing works
Seferović, P. M., Petrie, M. C., Filippatos, G. S., Anker, S. D., Rosano, G., Bauersachs, J., Paulus, W. J., Komajda, M., Cosentino, F., de Boer, R. A., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1170 · Cited by 708 · see citing works
Heart Failure in Type 2 Diabetes Mellitus
Kenny, H., & Abel, E. D. (2019) · Circulation Research · doi:10.1161/circresaha.118.311371 · Cited by 671 · see citing works
Pop‐Busui, R., Januzzi, J. L., Bruemmer, D., Butalia, S., Green, J. B., Horton, W. B., Knight, C. M., Levi, M., Rasouli, N., & Richardson, C. R. (2022) · Diabetes Care · doi:10.2337/dci22-0014 · Cited by 424 · see citing works
10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2025
American Diabetes Association Professional Practice Committee, ElSayed, N. A., McCoy, R. G., Aleppo, G., Balapattabi, K., Beverly, E. A., Briggs Early, K., Bruemmer, D., Das, S. R., Echouffo-Tcheugui, J. B., et al. (2025) · Diabetes Care · doi:10.2337/dc25-s010 · Cited by 339 · see citing works
Diabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging
Ng, A. C. T., Delgado, V., Borlaug, B. A., & Bax, J. J. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00465-5 · Cited by 339 · see citing works
Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy
Knapp, M., Tu, X., & Wu, R. (2018) · Acta Pharmacologica Sinica · doi:10.1038/s41401-018-0042-6 · Cited by 329 · see citing works
Maddox, T. M., Januzzi, J. L., Allen, L. A., Breathett, K., Brouse, S., Butler, J., Davis, L. L., Fonarow, G. C., Ibrahim, N. E., Lindenfeld, J., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.12.024 · Cited by 362 · see citing works
Self-citationHeart Failure With Preserved Ejection Fraction and Diabetes
McHugh, K., DeVore, A. D., Wu, J., Matsouaka, R. A., Fonarow, G. C., Heidenreich, P. A., Yancy, C. W., Green, J. B., Altman, N., & Hernandez, A. F. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.11.033 · Cited by 313 · see citing works
Yancy, C. W., Januzzi, J. L., Allen, L. A., Butler, J., Davis, L. L., Fonarow, G. C., Ibrahim, N. E., Jessup, M. L., Lindenfeld, J., Maddox, T. M., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.025 · Cited by 278 · see citing works
Diabetes, heart failure, and renal dysfunction: The vicious circles
D, E. B. M. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.07.003 · Cited by 252 · see citing works
Anker, S. D., Usman, M., Anker, M. S., Butler, J., Böhm, M., Abraham, W. T., Adamo, M., Chopra, V., Cicoira, M., Cosentino, F., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.2894 · Cited by 204 · see citing works
Filippatos, G., Butler, J., Farmakis, D., Zannad, F., Ofstad, A. P., Ferreira, J. P., Green, J. B., Rosenstock, J., Schnaidt, S., Brueckmann, M., et al. (2022) · Circulation · doi:10.1161/circulationaha.122.059785 · Cited by 131 · see citing works
Palazzuoli, A., & Iacoviello, M. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10238-6 · Cited by 122 · see citing works
10. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes—2026
American Diabetes Association Professional Practice Committee for Diabetes*, Bajaj, M., McCoy, R. G., Balapattabi, K., Bannuru, R. R., Bellini, N. J., Bennett, A. K., Beverly, E. A., Briggs Early, K., ChallaSivaKanaka, S., et al. (2026) · Diabetes Care · doi:10.2337/dc26-s010 · Cited by 107 · see citing works
SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes
Wu, X., Liu, H., Brooks, A. C., Xu, S., Luo, J., Steiner, R., Mickelsen, D. M., Moravec, C. S., Alexis, J. D., Small, E. M., et al. (2022) · Circulation Research · doi:10.1161/circresaha.121.318988 · Cited by 98 · see citing works
The impact of diabetes mellitus on the clinical phenotype of hypertrophic cardiomyopathy
Wasserstrum, Y., Villa, R. B., Fernández, X., Adler, Y., Lotan, D., Peled, Y., Klempfner, R., Kuperstein, R., Nir, S., Sabbag, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy625 · Cited by 79 · see citing works
Targeting obesity and diabetes to treat heart failure with preserved ejection fraction
Altara, R., Giordano, M., Nordén, E. S., Cataliotti, A., Kurdi, M., Bajestani, S. N., & Booz, G. W. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00160 · Cited by 61 · see citing works
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Rinaldi, L., Coviello, F., Di Martino, A., Albanese, G., Colantuoni, S., Medicamento, G., et al. (2022) · Biomolecules · doi:10.3390/biom12020176 · Cited by 62 · see citing works
Heather, L. C., Gopal, K., Srnic, N., & Ussher, J. R. (2024) · Diabetes · doi:10.2337/dbi23-0019 · Cited by 59 · see citing works
Lejeune, S., Roy, C., Slimani, A., Pasquet, A., Vancraeynest, D., Vanoverschelde, J., Gerber, B. L., Beauloye, C., & Pouleur, A. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01242-5 · Cited by 56 · see citing works
Dapagliflozin for Heart Failure with Preserved Ejection Fraction: Will the DELIVER Study Deliver?
Williams, D. M., & Evans, M. (2020) · Diabetes Therapy · doi:10.1007/s13300-020-00911-0 · Cited by 55 · see citing works
Monma, Y., Shindo, T., Eguchi, K., Kurosawa, R., Kagaya, Y., Ikumi, Y., Ichijo, S., Nakata, T., Miyata, S., Matsumoto, A., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa221 · Cited by 55 · see citing works
Diabetes and Progression of Heart Failure
Echouffo-Tcheugui, J. B., Ndumele, C. E., Zhang, S., Florido, R., Matsushita, K., Coresh, J., Skali, H., Shah, A. M., & Selvin, E. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.03.378 · Cited by 54 · see citing works
Lee, K. S., Park, D.-I., Lee, J., Oh, O., Kim, N., & Nam, G. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03527-x · Cited by 52 · see citing works
Evans, M., Morgan, A. R., Patel, D., Dhatariya, K., Greenwood, S. A., Newland‐Jones, P., Hicks, D., Yousef, Z. R., Moore, J., Kelly, B., et al. (2020) · Diabetes Therapy · doi:10.1007/s13300-020-00963-2 · Cited by 48 · see citing works
Metabolic rewiring and inter-organ crosstalk in diabetic HFpEF
Luo, L., Zuo, Y., & Dai, L. (2025) · Cardiovascular Diabetology · doi:10.1186/s12933-025-02707-7 · Cited by 51 · see citing works
SGLT2 inhibitors: a focus on cardiac benefits and potential mechanisms
Muric, M. D., Zivkovic, V. I., Joksimović, J., Sretenovic, J. Z., Davidović, G., Simovic, S. M., Djoković, D., Muric, N. N., Bolevich, S., & Jakovljevic, V. L. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10079-9 · Cited by 44 · see citing works
Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart
Fu, Q., Wang, Q., & Xiang, Y. K. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.02.002 · Cited by 43 · see citing works
Chen, J. C., Wang, Q., Li, R., Li, Z., Jiang, Q., Yan, F., & Ye, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122187 · Cited by 40 · see citing works
Corrination of a GLP-1 Receptor Agonist for Glycemic Control without Emesis
Borner, T., Workinger, J. L., Tinsley, I. C., Fortin, S. M., Stein, L. M., Chepurny, O. G., Holz, G. G., Wierzba, A. J., Gryko, D., Nexø, E., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107768 · Cited by 39 · see citing works
Hanff, T. C., Cohen, J. B., Zhao, L., Javaheri, A., Zamani, P. L., Prenner, S. B., Rietzschel, E. R., Jia, Y., Walsh, A. M., Maranville, J., et al. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.11.011 · Cited by 34 · see citing works
Vetrone, L. M., Zaccardi, F., Webb, D. R., Seidu, S., Gholap, N. N., Pitocco, D., Davies, M. J., & Khunti, K. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1253-5 · Cited by 32 · see citing works
Glucose-Lowering Therapies and Heart Failure in Type 2 Diabetes Mellitus
Vijayakumar, S., Vaduganathan, M., & Butler, J. (2018) · Circulation · doi:10.1161/circulationaha.117.032099 · Cited by 32 · see citing works
Chiang, C., Ueng, K.-C., Chao, T., Lin, T., Wu, Y.-J., Wang, K.-L., Sung, S., Yeh, H., Li, Y., Liu, P., et al. (2020) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000359 · Cited by 30 · see citing works
Severe Hypoglycemia and Incident Heart Failure Among Adults With Type 2 Diabetes
Echouffo-Tcheugui, J. B., Kazé, A. D., Fonarow, G. C., & Dagogo-Jack, S. E. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab794 · Cited by 28 · see citing works
Kubota, Y., & Shimizu, W. (2022) · JACC Asia · doi:10.1016/j.jacasi.2022.03.009 · Cited by 29 · see citing works
A risk prediction model for heart failure hospitalization in type 2 diabetes mellitus
Williams, B. A., Geba, D., Cordova, J. M., & Shetty, S. S. (2019) · Clinical Cardiology · doi:10.1002/clc.23298 · Cited by 28 · see citing works
SGLT-2 Inhibitors in Heart Failure and Type-2 Diabetes: Hitting Two Birds with One Stone?
Santos‐Ferreira, D., Gonçalves-Teixeira, P., & Fontes‐Carvalho, R. (2019) · Cardiology · doi:10.1159/000504694 · Cited by 27 · see citing works
Mechanick, J. I., Pessah-Pollack, R., Camacho, P., Correa, R., Figaro, M. K., Garber, J. R., Jasim, S., Pantalone, K. M., Trence, D., & Upala, S. (2017) · Endocrine Practice · doi:10.4158/ep171866.gl · Cited by 25 · see citing works
Chapter 1: The Burden of Heart Failure.
Pratley, R., Guan, X., Moro, R., & Lago, R. D. (2024) · American Journal of Medicine · doi:10.1016/j.amjmed.2023.04.018 · Cited by 21 · see citing works
Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific
Tan, E. S. J., Tay, W. T., Teng, T. K., Sim, D., Leong, K. T. G., Yeo, P. S. D., Ong, H. Y., Jaufeerally, F. R., Ng, T. P., Poppe, K., et al. (2019) · Heart · doi:10.1136/heartjnl-2018-314077 · Cited by 24 · see citing works
Gandin, I., Saccani, S., Coser, A., Scagnetto, A., Cappelletto, C., Candido, R., Barbati, G., & Lenarda, A. D. (2023) · PLoS ONE · doi:10.1371/journal.pone.0281878 · Cited by 23 · see citing works
Chiang, C., Lin, S.-Y., Lin, T., Wang, T., Yeh, H., Chen, J., Tsai, C., Hung, Y.-J., Li, Y., Liu, P., et al. (2018) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2018.01.001 · Cited by 22 · see citing works
Oikonomou, E. K., Mourouzis, K., Fountoulakis, P. N., Papamikroulis, G.-A., Siasos, G., Antonopoulos, A. S., Vogiatzi, G., Tsalamadris, S., Vavuranakis, M., & Tousoulis, D. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9682-3 · Cited by 22 · see citing works
Martinez, C., Zheng, A., & Xiao, Q. (2024) · Antioxidants · doi:10.3390/antiox13111330 · Cited by 26 · see citing works
Ziaeian, B., Hernandez, A. F., DeVore, A. D., Wu, J., Xu, H., Heidenreich, P. A., Matsouaka, R., Bhatt, D. L., Yancy, C. W., & Fonarow, G. C. (2019) · American Heart Journal · doi:10.1016/j.ahj.2019.01.006 · Cited by 21 · see citing works
Zoppini, G., Bergamini, C., Mantovani, A., Dauriz, M., Targher, G., Rossi, A., & Bonora, E. (2018) · PLoS ONE · doi:10.1371/journal.pone.0209794 · Cited by 20 · see citing works
Capillaries as a Therapeutic Target for Heart Failure
Yoshida, Y., Shimizu, I., & Minamino, T. (2022) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.rv17064 · Cited by 20 · see citing works
How Diabetes and Heart Failure Modulate Each Other and Condition Management
Randhawa, V. K., Dhanvantari, S., & Connelly, K. A. (2020) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2020.11.014 · Cited by 20 · see citing works
Williams, D. M., & Evans, M. (2020) · Diabetes Therapy · doi:10.1007/s13300-020-00889-9 · Cited by 19 · see citing works
Carrera, M. J., Moliner, P., Llauradó, G., Enjuanes, C., Conangla, L., Chillarón, J. J., Ballesta, S., Climent, E., Colet, J. C., & Roux, J. A. F. L. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm11010006 · Cited by 18 · see citing works
Diabetes, Heart Failure, and COVID-19: An Update
Hebbard, C., Lee, B., Katare, R., & Garikipati, V. N. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.706185 · Cited by 19 · see citing works
Zhong, L., Li, J., Yu, J., Cao, X., Du, J., Liang, L., Yang, M., Yue, Y., Zhao, M., Zhou, T., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117250 · Cited by 17 · see citing works
Valensi, P. E. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02436-3 · Cited by 18 · see citing works
Ai, S., Wang, X., Wang, S., Zhao, Y., Guo, S., Li, G., Chen, Z., Lin, F., Guo, S. J., Li, Y., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01540-6 · Cited by 17 · see citing works
Heart failure and diabetes: Clinical significance and epidemiology of this two‐way association
Jerkins, T. W., McGill, J. B., & Bell, D. S. H. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15062 · Cited by 16 · see citing works
Cattadori, G., Pantanetti, P., & Ambrosio, G. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107835 · Cited by 16 · see citing works
Vuori, M. A., Reinikainen, J., Söderberg, S., Bergdahl, E., Jousilahti, P., Tunstall‐Pedoe, H., Zeller, T., Westermann, D., Sans, S., Linneberg, A. R., et al. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01378-4 · Cited by 16 · see citing works
Diabetes Mellitus and Heart Failure
Siao, W.-Z., Chen, Y.-H., Tsai, C., Lee, C.-M., & Jong, G. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12101698 · Cited by 16 · see citing works
Khandait, H., Sodhi, S., Khandekar, N., & Bhattad, V. (2025) · CardioRenal Medicine · doi:10.1159/000542633 · Cited by 17 · see citing works
The application of procyanidins in diabetes and its complications: a review of preclinical studies
Zhang, Y., Li, M., Liu, H., Fan, Y., & Liu, H. H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1532246 · Cited by 15 · see citing works
Mekhaimar, M., Dargham, S., El-Shazly, M., Suwaidi, J. A., Jneid, H., & Khalil, C. A. (2020) · Heart Failure Reviews · doi:10.1007/s10741-020-10012-6 · Cited by 15 · see citing works
Alrob, O. A., Sankaralingam, S., Al-Azzam, S. I., Nusairat, B., Qattoum, M. N., & Nusair, M. B. (2022) · Medicina · doi:10.3390/medicina59010060 · Cited by 15 · see citing works
Muñoz‐Rivas, N., Jiménez‐García, R., Méndez‐Bailón, M., Hernández‐Barrera, V., de Miguel‐Díez, J., Lorenzo-Villalba, N., de Miguel-Yanes, J. M., & López‐de‐Andrés, A. (2018) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2018.08.011 · Cited by 14 · see citing works
Lin, Y., Xie, M., Zhang, L., Zhang, Y., Zhang, P., Chen, X., Ji, M., Gao, L., He, Q., Wu, Z., et al. (2025) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.124.016975 · Cited by 13 · see citing works
Furukawa, N., Matsui, H., Sunaga, H., Nagata, K., Hirayama, M., Obinata, H., Yokoyama, T., Ohno, K., Kurabayashi, M., & Koitabashi, N. (2024) · Scientific Reports · doi:10.1038/s41598-024-75757-8 · Cited by 12 · see citing works
Mahtani, K., Patel, B., Wang, B. Z., & Barron, A. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.08.015 · Cited by 12 · see citing works
Cavallari, I., Maddaloni, E., Pieralice, S., Mulè, M. T., Buzzetti, R., Ussia, G. P., Pozzilli, P., & Grigioni, F. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa427 · Cited by 12 · see citing works
Xu, Q., Ding, H., Li, S., Dong, S., Li, L., Shi, B., Zhong, M., & Zhang, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.785799 · Cited by 11 · see citing works
Glycemic Markers and Heart Failure Subtypes: The Multi-Ethnic Study of Atherosclerosis (MESA)
Echouffo-Tcheugui, J. B., Ogunmoroti, O., Golden, S. H., Bertoni, A. G., Mongraw‐Chaffin, M., Pandey, A., Ndumele, C. E., & Michos, E. D. (2022) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2022.01.011 · Cited by 11 · see citing works
Targeting the Metabolic-Inflammatory Circuit in Heart Failure With Preserved Ejection Fraction
Yap, E. P., Ja, K. P. M. M., & Ramachandra, C. J. A. (2022) · Current Heart Failure Reports · doi:10.1007/s11897-022-00546-1 · Cited by 11 · see citing works
Ethnic Differences in Atrial Fibrillation Among Patients with Heart Failure in Asia
Tan, E. S. J., Goh, V. J., Santema, B. T., Tay, W. T., Teng, T. K., Yap, J. J. L., Tromp, J., Hung, C., Chopra, V., Anand, I. S., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12696 · Cited by 11 · see citing works
COHEN, L. P., Vittinghoff, E., Pletcher, M. J., Allen, N. B., Shah, S. J., Wilkins, J. T., Chang, P. P., Ndumele, C. E., Newman, A. B., Ives, D. G., et al. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.11.008 · Cited by 11 · see citing works
Zhou, Y., Wang, M., Wang, S., Li, N., Zhang, S., Tang, S., Shi, Q., Zhao, Y., Li, J., Zeng, Y., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.727188 · Cited by 12 · see citing works
Masip, J., Povar-Echeverría, M., Peacock, W. F., Jacob, J., Gil, V., Herrero, P., Llorens, P., Alquézar‐Arbé, A., Sánchez, C., Martín‐Sánchez, F. J., et al. (2022) · Internal and Emergency Medicine · doi:10.1007/s11739-022-02965-3 · Cited by 11 · see citing works
Yuan, P., Liu, J., Xiong, S., Yang, L., Guan, J., Dong, G., & Shi, D. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116558 · Cited by 10 · see citing works
Guo, Z., Li, Y.-K., An, S.-Y., & Zheng, J. (2025) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-025-01661-4 · Cited by 10 · see citing works
Vericiguat and Cardiovascular Outcomes in Heart Failure by Baseline Diabetes Status
Khan, M. S., Butler, J., Young, R., Lewis, B. S., Escobedo, J., Refsgaard, J. C., Reyes, E. B., Roessig, L., Blaustein, R. O., Lam, C. S. P., et al. (2024) · JACC Heart Failure · doi:10.1016/j.jchf.2024.05.007 · Cited by 9 · see citing works
Martínez-Morata, I., Domingo‐Relloso, A., Zhang, Y., Fretts, A. M., Pichler, G., García‐Pinilla, J. M., Umans, J. G., Cole, S. A., Sun, Y., Shimbo, D., et al. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.123.033772 · Cited by 9 · see citing works
Mehta, A., Bhattacharya, S., Estep, J. D., & Faiman, C. (2020) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2020.04.005 · Cited by 9 · see citing works
Winell, K., Pietilä, A., & Salomaa, V. V. (2019) · Annals of Medicine · doi:10.1080/07853890.2019.1602734 · Cited by 9 · see citing works
Lawson, C. A., Zaccardi, F., McCann, G. P., Davies, M. J., Kadam, U. T., & Khunti, K. K. (2019) · JAMA Network Open · doi:10.1001/jamanetworkopen.2019.16447 · Cited by 9 · see citing works
Arévalo‐Lorido, J. C., Carretero‐Gómez, J., Gómez‐Huelgas, R., Llàcer, P., Manzano, L., Simón, M. A. Q., Roca, B., Franco, Á. G., Cepeda, J. M., & Pérez‐Barquero, M. M. (2020) · International Journal of Clinical Practice · doi:10.1111/ijcp.13661 · Cited by 9 · see citing works
Nguyen, C., Luthra, R., Kuti, E. L., & Willey, V. J. (2020) · Current Medical Research and Opinion · doi:10.1080/03007995.2020.1832455 · Cited by 8 · see citing works
Diabetes mellitus and the causes of hospitalisation in people with heart failure
Malik, A., Garland, E., Drozd, M., Palin, V., Giannoudi, M., Straw, S., Jex, N., Walker, A. M., Gierula, J., Paton, M. F., et al. (2022) · Diabetes and Vascular Disease Research · doi:10.1177/14791641211073943 · Cited by 8 · see citing works
Elevated ITGA1 levels in type 2 diabetes: implications for cardiac function impairment
Su, M., Hou, Y., Cai, S., Li, W., Wei, Y., Wang, R., Wu, M., Liu, M., Chang, J., Yang, K., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06109-4 · Cited by 8 · see citing works
Kim, J., Wang, S.-S., Sikirica, S., & Shafrin, J. (2023) · medRxiv · doi:10.57264/cer-2023-0190 · Cited by 6 · see citing works
An evaluation of canagliflozin for the treatment of type 2 diabetes: an update
Minami, T., Kameda, A., & Terauchi, Y. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1939675 · Cited by 8 · see citing works
Kim, J. Y., Kim, N. H., Lee, J. Y., Kim, D., & Kim, S. G. (2025) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvaf053 · Cited by 7 · see citing works
Yu, H., Basu, S., Tang, W., Penland, R. C., Greasley, P. J., Oscarsson, J., Boulton, D. W., & Hallow, K. M. (2021) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.1987 · Cited by 7 · see citing works
Cheng, J. W. M., Colucci, V. J., Kalus, J. S., & Spinler, S. A. (2023) · Annals of Pharmacotherapy · doi:10.1177/10600280231154021 · Cited by 7 · see citing works
Koliaki, C. C., & Katsilambros, N. L. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17010155 · Cited by 7 · see citing works
Cox, Z. L., Lai, P., Lewis, C. M., & Lindenfeld, J. M. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.07.069 · Cited by 6 · see citing works
Dysglycemia and incident heart failure among blacks: The jackson heart study
Echouffo-Tcheugui, J. B., Mwasongwe, S. E., Musani, S. K., Hall, M. E., Correa, A., Hernandez, A. F., Golden, S. H., Mentz, R. J., & Bertoni, A. G. (2021) · American Heart Journal · doi:10.1016/j.ahj.2021.11.003 · Cited by 6 · see citing works
Renal risk stratification in left ventricular assist device therapy
Givens, R. C., & Topkara, V. K. (2017) · Expert Review of Medical Devices · doi:10.1080/17434440.2018.1418663 · Cited by 6 · see citing works
Aging and Heart Failure with Preserved Ejection Fraction
Larson, K. F., Malik, A., & Brozovich, F. V. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210035 · Cited by 11 · see citing works
Zuo, G., Wang, L., Huang, L., Ren, Y., Ge, Z., Hu, Z., Zhang, J., & Chen, S. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166979 · Cited by 5 · see citing works
Aging and Heart Failure with Preserved Ejection Fraction
Larson, K. F., Malik, A., & Brozovich, F. V. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00233.x · Cited by 5 · see citing works
Intersection Between Diabetes and Heart Failure: Is SGLT2i the “One Stone for Two Birds” Approach?
Zhang, Q., Kang, Y., Tang, S., & Yu, C.-M. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01591-3 · Cited by 2 · see citing works
- Authors
- Echouffo-Tcheugui, J. B., Xu, H., DeVore, A. D., Schulte, P. J., Butler, J., Yancy, C. W., Bhatt, D. L., Hernandez, A. F., Heidenreich, P. A., & Fonarow, G. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Duke Clinical Research Institute (US)
- Mayo Clinic (US)
- Stony Brook University (US)
- Northwestern University (US)
- VA Palo Alto Health Care System (US)
- University of California, Los Angeles (US)
- Corresponding author
- Echouffo-Tcheugui, Justin B.
- ORCID
- Venue
- American Heart Journal
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 182
- Pages
- 9-20
- ISSN
- 0002-8703 (ISSN-L)
- OpenAlex
- W2508250664
- Cited by
- 160
- References
- 41
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 24 · 2023: 16 · 2022: 28 · 2021: 21 · 2020: 22 · 2019: 13 · 2018: 11 · 2017: 5
- FWCI
- 7.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of California, Los Angeles
- Ahmanson Foundation
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, heart failure, temporal trends, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, in-hospital mortality, length of hospital stay, quality of care, new-onset diabetes, hospitalized patients
- MeSH terms
- Aged, Aged, 80 and over, Diabetes Mellitus, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Registries, Socioeconomic Factors, Stroke Volume, United States, Comorbidity, Prevalence, Hospital Mortality
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
