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Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort
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“While many composite biomarkers of aging have shown some evidence of comparable predictive accuracy across genetic ancestry populations 24 70 71, establishing diverse cohorts with non-European ancestries to validate new composite biomarkers of aging remains a priority.”
From Validation of biomarkers of aging (2024) · cites this paper as [70]
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The 1000 Genomes Project Consortium, authors, C., Auton, A., Abecasis, G. R., Steering committee, Altshuler, D. M., Durbin, R. M., Abecasis, G. R., Bentley, D. R., Chakravarti, A., et al. (2015) · Nature · doi:10.1038/nature15393 · Cited by 18,247
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Zou, H. (2006) · Journal of the American Statistical Association · doi:10.1198/016214506000000735 · Cited by 7,470
Clinical use of current polygenic risk scores may exacerbate health disparities
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the CARDIoGRAMplusC4D Consortium (2015) · Nature Genetics · doi:10.1038/ng.3396 · Cited by 2,447
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Validation of biomarkers of aging
Moqri, M., Herzog, C., Poganik, J. R., Ying, K., Justice, J. N., Belsky, D. W., Higgins-Chen, A. T., Chen, B. H., Cohen, A. A., Fuellen, G., et al. (2024) · Nature Medicine · doi:10.1038/s41591-023-02784-9 · Cited by 361
Privé, F. (2022) · Bioinformatics · doi:10.1093/bioinformatics/btac348 · Cited by 33
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Metadata
- Authors
- Privé, F., Aschard, H., Carmi, S., Folkersen, L., Hoggart, C., O’Reilly, P. F., & Vilhjálmsson, B. J.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 109
- Issue
- 1
- Pages
- 12-23
- ISSN
- 0002-9297
- Cited by
- 375
- References
- 18
- Language
- en
- Update notices
- erratum (2022-02-03)
- Licence
- Funders
- Danish National Research Foundation
- Lundbeckfonden (R248-2017-2003, R335-2019-2339)
- Aarhus Universitet (58024)
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