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Cited by 203Retinal Diseases and TreatmentsRetinal Imaging and AnalysisRetinal and Macular Surgery

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Pathogenesis of lesions in late age-related macular disease

Holz, Frank G., Pauleikhoff, Daniel, Klein, Ronald, Bird, Alan C.·2004·American Journal of Ophthalmology
DOI 10.1016/j.ajo.2003.11.026
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Abstract

Purpose To review the evidence that exists concerning the pathogenesis of lesions in late age-related macular disease (AMD).Design Review of the literature.Methods A review of both experimental evidence and clinical observations that address these problems.Results There is good evidence that choroidal neovascularization (CNV) is due to a change in the balance of growth factors derived from the retinal pigment epithelial basolateral plasma membrane domain (retinal pigment epithelium). Retinal angiomatous proliferation may also have a similar pathogenesis involving the apical domain. Detachment of the retinal pigment epithelium is likely to be a consequence of increased resistance of the Bruch membrane to water flow due to deposition of lipids. Geographic atrophy is preceded by accumulation of autofluorescent material in the retinal pigment epithelium and possible causal relationships between the two have been demonstrated.Conclusion There is increasing understanding concerning the sequence of events that lead to those lesions causing loss of central vision in AMD. Therapeutic approaches that address the underlying mechanisms are more likely to succeed than current treatment options. Such an approach has already been initiated in the management of choroidal neovascularization.

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Crossref · 10.1016/j.ajo.2003.11.026

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Citations

Cites

Research works printed but not linked: 3

  1. 1986, Argon laser photocoagulation for neovascular maculopathy. Three-year results from randomized clinical trials, Arch Ophthalmol, 104, 503
  2. Moore, 1995, Age related variation in the hydraulic conductivity of Bruch's membrane, Invest Ophthalmol Vis Sci, 36, 1290
  3. Rozanowska, 2002, Photoreactivity of aged human RPE melanosomes, Invest Ophthalmol Vis Sci, 43, 2088

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Metadata

Authors
Holz, F. G., Pauleikhoff, D., Klein, R., & Bird, A. C.
Affiliations
  • Heidelberg University (DE)
  • St. Franziskus Hospital (DE)
  • University of Wisconsin–Madison (US)
  • University of London (GB)
Corresponding author
Bird, Alan C.
ORCID
Venue
American Journal of Ophthalmology
Publisher
Elsevier BV
Published
2004-03
Volume
137
Issue
3
Pages
504-510
ISSN
0002-9394 (ISSN-L)
DOI
10.1016/j.ajo.2003.11.026
OpenAlex
W2168896662
Cited by
203
References
53
Citations by year
2025: 2 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 11 · 2012: 13
FWCI
2.97
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
Keywords
age-related macular degeneration, choroidal neovascularization, retinal pigment epithelium, retinal angiomatous proliferation, pigment epithelial detachment, Bruch's membrane, geographic atrophy, lipofuscin accumulation, growth factors, pathogenesis
MeSH terms
Humans, Macular Degeneration, Vision Disorders

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