Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration
Abstract
Purpose To test if fundus autofluorescence (FAF) patterns around geographic atrophy (GA) have an impact on GA progression rates over time in atrophic age-related macular degeneration (AMD).Design Prospective longitudinal multicenter natural history study.Methods Standardized digital FAF images were obtained from 195 eyes of 129 patients with GA using confocal scanning laser ophthalmoscopy (excitation 488 nm, emission >500 nm). Areas of GA were quantified and patterns of abnormal FAF in the junctional zone were classified. Repeated FAF images were obtained over a median follow-up period of 1.80 years (interquartile range [IQR], 1.28 to 3.34).Results Areas of GA (median, 7.04 mm(2) at baseline; IQR, 3.12 to 10.0) showed a median enlargement of 1.52 mm(2)/year (IQR, 0.81 to 2.33). Progression rates in eyes with the banded (median 1.81 mm(2)/year) and the diffuse FAF pattern (1.77 mm(2)/year) were significantly higher compared to eyes without FAF abnormalities (0.38 mm(2)/year) and focal FAF patterns (0.81 mm(2)/year, P < .0001). Within the group of the diffuse pattern, eyes with a diffuse trickling pattern could be identified that exhibited an even higher spread rate (median 3.02 mm(2)/year) compared to the other diffuse types (1.67 mm(2)/year, P = .001).Conclusions The results indicate that distinct phenotypic FAF patterns have an impact on disease progression in eyes with atrophic AMD and may therefore serve as prognostic determinants. The findings underscore the relevance of FAF imaging and the pathogenetic role of excessive retinal pigment epithelium (RPE) lipofuscin (LF) accumulation in GA. Natural history data and identification of high-risk characteristics will be helpful to design interventional studies aiming at slowing the spread of atrophy.
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Specific patterns of fundus autofluorescence were associated with progression of geographic atrophy.
“Specific patterns of fundus autofluorescence were associated with progression of geographic atrophy; this technique could be an important imaging method to monitor patients with geographic atrophy associated with age-related macular degeneration.132”
From Age-related macular degeneration (2008) · cites this paper as [132]
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- Authors
- Holz, F. G., Bindewald-Wittich, A., Fleckenstein, M., Dreyhaupt, J., Scholl, H. P. N., & Schmitz-Valckenberg, S.
- Affiliations
- University of Bonn (DE)
- Heidelberg University (DE)
- Corresponding author
- Holz, Frank G.
- ORCID
- Venue
- American Journal of Ophthalmology
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 143
- Issue
- 3
- Pages
- 463-472.e2
- ISSN
- 0002-9394 (ISSN-L)
- OpenAlex
- W2032463068
- Cited by
- 619
- References
- 62
- Citations by year
- 2026: 39 · 2025: 29 · 2024: 37 · 2023: 25 · 2022: 16 · 2021: 41 · 2020: 36 · 2019: 32 · 2018: 28 · 2017: 34 · 2016: 37 · 2015: 40 · 2014: 30 · 2013: 37 · 2012: 40
- FWCI
- 13.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- geographic atrophy, age-related macular degeneration, disease progression, retinal pigment epithelium, lipofuscin accumulation, junctional zone, prognostic factors, natural history (disease)
- MeSH terms
- Aged, Atrophy, Female, Fluorescence, Fundus Oculi, Humans, Macular Degeneration, Male, Ophthalmoscopy, Pigment Epithelium of Eye, Prospective Studies, Disease Progression
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