Cited by 203Retinal Diseases and TreatmentsRetinal Imaging and AnalysisRetinal and Macular Surgery

The DOI matches its Crossref record; 52 of the 53 references it cites were found in a registry or an index.

Pathogenesis of lesions in late age-related macular disease

Holz, Frank G., Pauleikhoff, Daniel, Klein, Ronald, Bird, Alan C.·2004·American Journal of Ophthalmology

DOI 10.1016/j.ajo.2003.11.026

Open this paper in CoChat — free account

Abstract

Purpose To review the evidence that exists concerning the pathogenesis of lesions in late age-related macular disease (AMD).Design Review of the literature.Methods A review of both experimental evidence and clinical observations that address these problems.Results There is good evidence that choroidal neovascularization (CNV) is due to a change in the balance of growth factors derived from the retinal pigment epithelial basolateral plasma membrane domain (retinal pigment epithelium). Retinal angiomatous proliferation may also have a similar pathogenesis involving the apical domain. Detachment of the retinal pigment epithelium is likely to be a consequence of increased resistance of the Bruch membrane to water flow due to deposition of lipids. Geographic atrophy is preceded by accumulation of autofluorescent material in the retinal pigment epithelium and possible causal relationships between the two have been demonstrated.Conclusion There is increasing understanding concerning the sequence of events that lead to those lesions causing loss of central vision in AMD. Therapeutic approaches that address the underlying mechanisms are more likely to succeed than current treatment options. Such an approach has already been initiated in the management of choroidal neovascularization.

Integrity signals

Registry

Crossref · 10.1016/j.ajo.2003.11.026

Cites

52 of 52 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Age-related Macular Degeneration With Verteporfin
Treatment of Age-related Macular Degeneration With Photodynamic Therapy (TAP) Study Group (1999) · Archives of Ophthalmology · doi:10.1001/archopht.117.10.1329 · Cited by 2,192
Vascular endothelial growth factors and angiogenesis in eye disease
Witmer, A. N. (2003) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00043-5 · Cited by 945
In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics.
Delori, F. C., Dorey, C. K., Staurenghi, G., Arend, O., Goger, D. G., & Weiter, J. J. (1995) · PubMed · Cited by 938
Photoreceptor loss in age-related macular degeneration.
Curcio, C. A., Medeiros, N. E., & Millican, C. L. (1996) · PubMed · Cited by 802
Morphometric analysis of Bruch's membrane, the choriocapillaris, and the choroid in aging.
Ramrattan, R. S., van der Schaft, T. L., Mooy, C. M., de Bruijn, W. C., Mulder, P. G. H., & de Jong, P. T. (1994) · PubMed · Cited by 744
Pathogenesis of Disciform Detachment of the Neuroepithelium
Donald, J. S., & Gass, M. (1967) · American Journal of Ophthalmology · doi:10.1016/0002-9394(67)90030-x · Cited by 680
RETINAL ANGIOMATOUS PROLIFERATION IN AGE–RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2012) · Retina · doi:10.1097/iae.0b013e31823f9b3b · Cited by 660
RETINAL ANGIOMATOUS PROLIFERATION IN AGE-RELATED MACULAR DEGENERATION
Yannuzzi, L. A., Negrão, S., Iida, T., CARVALHO, C., Rodriguez-Coleman, H., Slakter, J. S., Freund, K. B., Sorenson, J. A., Orlock, D. A., & Borodoker, N. (2001) · Retina · doi:10.1097/00006982-200110000-00003 · Cited by 658
TREATMENT OF AGE-RELATED MACULAR DEGENERATION WITH PHOTODYNAMIC THERAPY (TAP) STUDY GROUP. PHOTODYNAMIC THERAPY OF SUBFOVEAL CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION WITH VERTEPORFIN: TWO-YEAR RESULTS OF 2 RANDOMIZED CLINICAL TRIALS-TAP REPORT 2
Bressler, N. M. (2001) · Cited by 599
Prevention of Experimental Choroidal Neovascularization With Intravitreal Anti–Vascular Endothelial Growth Factor Antibody Fragment
Krzystolik, M. G. (2002) · Archives of Ophthalmology · doi:10.1001/archopht.120.3.338 · Cited by 591

Show all 53 references

Research works printed but not linked: 3

1986, Argon laser photocoagulation for neovascular maculopathy. Three-year results from randomized clinical trials, Arch Ophthalmol, 104, 503
Moore, 1995, Age related variation in the hydraulic conductivity of Bruch's membrane, Invest Ophthalmol Vis Sci, 36, 1290
Rozanowska, 2002, Photoreactivity of aged human RPE melanosomes, Invest Ophthalmol Vis Sci, 43, 2088

Sorted by citations

The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828
Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Mandai, M., Watanabe, A., Kurimoto, Y., Hirami, Y., Morinaga, C., Daimon, T., Fujihara, M., Akimaru, H., Sakai, N., Shibata, Y., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1608368 · Cited by 1,570
Intravitreal Bevacizumab (Avastin) for Neovascular Age-Related Macular Degeneration
Avery, R. L., Pieramici, D. J., Rabena, M., CASTELLARIN, A. A., Nasir, M. A., & Giust, M. J. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2005.11.019 · Cited by 1,134
Systemic Bevacizumab (Avastin) Therapy for Neovascular Age-Related Macular DegenerationTwelve-Week Results of an Uncontrolled Open-Label Clinical Study
Michels, S., Rosenfeld, P. J., Puliafito, C. A., MARCUS, E., & Venkatraman, A. (2005) · Ophthalmology · doi:10.1016/j.ophtha.2005.02.007 · Cited by 665
Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration
Holz, F. G., Bindewald-Wittich, A., Fleckenstein, M., Dreyhaupt, J., Scholl, H. P. N., & Schmitz-Valckenberg, S. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2006.11.041 · Cited by 619
FUNDUS AUTOFLUORESCENCE IMAGING
Schmitz-Valckenberg, S., Holz, F. G., Bird, A. C., & Spaide, R. F. (2008) · Retina · doi:10.1097/iae.0b013e318164a907 · Cited by 538
Age-related macular degeneration
Coleman, H. R., Chan, C.-C., Ferris, F. L., & Chew, E. Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61759-6 · Cited by 542
Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue
Maminishkis, A., Chen, S., Jalickee, S., Banzon, T., Shi, G., Wang, F. E., Ehalt, T., Hammer, J. A., & Miller, S. S. (2006) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.05-1622 · Cited by 401
Age‐related maculopathy and the impact of blue light hazard
Algvere, P. V., Marshall, J., & Seregard, S. (2006) · Acta Ophthalmologica Scandinavica · doi:10.1111/j.1600-0420.2005.00627.x · Cited by 399
Membranoproliferative Glomerulonephritis Type II (Dense Deposit Disease)
Appel, G. B., Cook, H. T., Hageman, G. S., Jennette, J. C., Kashgarian, M. J., Kirschfink, M., Lambris, J. D., Lanning, L. D., Lutz, H. U., Meri, S., et al. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010078 · Cited by 378
Obesity and Eye Diseases
Cheung, N., & Wong, T. Y. (2007) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2006.12.003 · Cited by 355
OCT angiography and evaluation of the choroid and choroidal vascular disorders
Borrelli, E., Sarraf, D., Freund, K. B., & Sadda, S. R. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.07.002 · Cited by 326
Ranibizumab: Phase III clinical trial results.
Rosenfeld, P. J., Rich, R., & Lalwani, G. A. (2006) · PubMed · doi:10.1016/j.ohc.2006.05.009 · Cited by 301
High-Resolution Spectral Domain-OCT Imaging in Geographic Atrophy Associated with Age-Related Macular Degeneration
Fleckenstein, M., Issa, P. C., Helb, H. –., Schmitz-Valckenberg, S., Finger, R. P., Scholl, H. P. N., Loeffler, K. U., & Holz, F. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1967 · Cited by 283
Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography
Keane, P. A., Patel, P. J., Liakopoulos, S., Heussen, F. M., Sadda, S. R., & Tufail, A. (2012) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2012.01.006 · Cited by 291
Photoreceptor Layer Thinning over Drusen in Eyes with Age-Related Macular Degeneration Imaged In Vivo with Spectral-Domain Optical Coherence Tomography
Schuman, S. G., Koreishi, A. F., Farsiu, S., Jung, S., Izatt, J. A., & Toth, C. A. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2008.10.006 · Cited by 282
Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease)
Abrera-Abeleda, M. A., Nishimura, C. J., Smith, J. L. H., Sethi, S., McRae, J. L., Murphy, B. F., Silvestri, G., Skerka, C., Józsi, M., Zipfel, P. F., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.038315 · Cited by 215
Changes in cortical grey matter density associated with long-standing retinal visual field defects
Boucard, C. C., Hernowo, A. T., Maguire, R. P., Jansonius, N. M., Roerdink, J. B. T. M., Hooymans, J. M. M., & Cornelissen, F. W. (2009) · Brain · doi:10.1093/brain/awp119 · Cited by 214
Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy
Zhang, S. X., & Ma, J. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.09.002 · Cited by 213
αB Crystallin Is Apically Secreted within Exosomes by Polarized Human Retinal Pigment Epithelium and Provides Neuroprotection to Adjacent Cells
Sreekumar, P. G., Kannan, R., Kitamura, M., Spee, C. K., Barrón, E., Ryan, S. J., & Hinton, D. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012578 · Cited by 207
Ion channels in the RPE
WIMMERS, S., KARL, M., & STRAUSS, O. (2007) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.12.002 · Cited by 207
Imaging individual neurons in the retinal ganglion cell layer of the living eye
Rossi, E. A., Granger, C. E., Sharma, R., Yang, Q., Saito, K., Schwarz, C., Walters, S., Nozato, K., Zhang, J., Kawakami, T., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613445114 · Cited by 205
Fundus Autofluorescence and Progression of Age-related Macular Degeneration
Schmitz-Valckenberg, S., Fleckenstein, M., Scholl, H. P. N., & Holz, F. G. (2009) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2008.10.004 · Cited by 203
Roles for VEGF in the adult
Maharaj, A. S. R., & D'Amore, P. A. (2007) · Microvascular Research · doi:10.1016/j.mvr.2007.03.004 · Cited by 202
Treatment with 670 nm Light Up Regulates Cytochrome C Oxidase Expression and Reduces Inflammation in an Age-Related Macular Degeneration Model
Begum, R., Powner, M. B., Hudson, N., Hogg, C. R., & Jeffery, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057828 · Cited by 179
Retinal Pigment Epithelial Detachment
Zayit‐Soudry, S., Moroz, I., & Loewenstein, A. (2007) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2007.02.008 · Cited by 166
An update on the genetics of age-related macular degeneration
Scholl, H. P. N., Fleckenstein, M., Issa, P. C., Keilhauer, C. N., Holz, F. G., & Weber, B. H. F. (2007) · PubMed Central · doi:10.5283/epub.35844 · Cited by 156
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells
Krohne, T. U., Stratmann, N. K., Kopitz, J., & Holz, F. G. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2009.12.011 · Cited by 159
Animal models of ocular angiogenesis: from development to pathologies
Liu, C., Wang, Z., Sun, Y., & Chen, J. (2017) · The FASEB Journal · doi:10.1096/fj.201700336r · Cited by 157
Expression of VLDLR in the Retina and Evolution of Subretinal Neovascularization in the Knockout Mouse Model’s Retinal Angiomatous Proliferation
Hu, W., Jiang, A., Liang, J., Meng, H., Chang, B., Gao, H., & Qiao, X. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0870 · Cited by 117
REDUCED CHORIOCAPILLARIS FLOW IN EYES WITH TYPE 3 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION
Borrelli, E., Souied, E. H., Freund, K. B., Querques, G., Mière, A., Gal‐Or, O., Sacconi, R., Sadda, S. R., & Sarraf, D. (2018) · Retina · doi:10.1097/iae.0000000000002198 · Cited by 127
Heat shock proteins as gatekeepers of proteolytic pathways—Implications for age-related macular degeneration (AMD)
Kaarniranta, K., Salminen, A., Eskelinen, E., & Kopitz, J. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.01.001 · Cited by 126
Vascular endothelial growth factor: Therapeutic possibilities and challenges for the treatment of ischemia
Crafts, T. D., Jensen, A. R., Blocher-Smith, E. C., & Markel, T. A. (2014) · Cytokine · doi:10.1016/j.cyto.2014.08.005 · Cited by 115
Clinicopathologic Correlation of Anti–Vascular Endothelial Growth Factor–Treated Type 3 Neovascularization in Age-Related Macular Degeneration
Li, M., Dolz‐Marco, R., Messinger, J. D., Wang, L., Feist, R. M., Girkin, C. A., Gattoussi, S., Ferrara, D., Curcio, C. A., & Freund, K. B. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.08.019 · Cited by 110
CFH, C3 and ARMS2 Are Significant Risk Loci for Susceptibility but Not for Disease Progression of Geographic Atrophy Due to AMD
Scholl, H. P. N., Fleckenstein, M., Fritsche, L. G., Schmitz-Valckenberg, S., Göbel, A. P., Adrion, C., Herold, C., Keilhauer, C. N., Mackensen, F., Mößner, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007418 · Cited by 105
The Ubiquitin–Proteasome System in Retinal Health and Disease
Campello, L., Esteve-Rudd, J., Cuenca, N., & Martín‐Nieto, J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-012-8391-5 · Cited by 110
Dense deposit disease
Smith, R. J., Harris, C. L., & Pickering, M. C. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.04.005 · Cited by 101
Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action
Krohne, T. U., Kaemmerer, E., Holz, F. G., & Kopitz, J. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.10.014 · Cited by 101
BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration
Zhu, D., Wu, J., Spee, C. K., Ryan, S. J., & Hinton, D. R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809393200 · Cited by 98
The role of complement in C3 glomerulopathy
Zipfel, P. F., Skerka, C., Chen, Q., Wiech, T., Goodship, T. H. J., Johnson, S. A., Frémeaux‐Bacchi, V., Nester, C., de Córdoba, S. R., Noris, M., et al. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.03.012 · Cited by 91
Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells
Kalariya, N. M., Ramana, K. V., Sk, S., & van Kuijk, F. J. G. M. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.09.010 · Cited by 91
Age-related Macular Degeneration and Risk of Coronary Heart Disease and Stroke: The Cardiovascular Health Study
Sun, C., Klein, R., & Wong, T. Y. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.03.046 · Cited by 90
Cone Structure Imaged With Adaptive Optics Scanning Laser Ophthalmoscopy in Eyes With Nonneovascular Age-Related Macular Degeneration
Zayit‐Soudry, S., Duncan, J. L., Syed, R., Menghini, M., & Roorda, A. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-12433 · Cited by 87
Vitreomacular traction and exudative age‐related macular degeneration
Schulze, S. D., Hoerle, S., Mennel, S., & Kroll, P. B. (2008) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2008.01210.x · Cited by 89
VEGF-A 165 b Is Cytoprotective and Antiangiogenic in the Retina
Magnussen, A., Rennel, E., Hua, J., Bevan, H. S., Beazley‐Long, N., Lehrling, C., Gammons, M. V. R., Floege, J., Harper, S. J., Agostini, H. T., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4296 · Cited by 86
Retinal Pigment Epithelial Cells Synthesize Laminins, Including Laminin 5, and Adhere to Them through α3- and α6-Containing Integrins
Aisenbrey, S., Zhang, M., Bacher, D., Yee, J., Brunken, W. J., & Hunter, D. D. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1590 · Cited by 88
Correlation between Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence at the Margins of Geographic Atrophy
Brar, M., Kozak, I., Cheng, L., Bartsch, D., Yuson, R. M. S., Nigam, N., Oster, S. F., Mojana, F., & Freeman, W. R. (2009) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2009.04.022 · Cited by 84
Quality of life in age-related macular degeneration: a review of available vision-specific psychometric tools
Finger, R. P., Fleckenstein, M., Holz, F. G., & Scholl, H. P. N. (2008) · Quality of Life Research · doi:10.1007/s11136-008-9327-4 · Cited by 79
Morphometric analyses of the visual pathways in macular degeneration
Hernowo, A. T., Prins, D., Baseler, H. A., Plank, T., Gouws, A. D., Hooymans, J. M. M., Morland, A. B., Greenlee, M. W., & Cornelissen, F. W. (2013) · Cortex · doi:10.1016/j.cortex.2013.01.003 · Cited by 84
Inflammation in Dry Age-Related Macular Degeneration
Rodrigues, E. B. (2007) · Ophthalmologica · doi:10.1159/000099293 · Cited by 73
Angiopoietin-1 Suppresses Choroidal Neovascularization and Vascular Leakage
Lee, J., Park, D. Y., Park, D. Y., Park, I., Chang, W., Nakaoka, Y., Komuro, I., Yoo, O.-J., & Koh, G. Y. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-13897 · Cited by 72
Human Retinal Pigment Epithelium: In Vivo Cell Morphometry, Multispectral Autofluorescence, and Relationship to Cone Mosaic
Granger, C. E., Yang, Q., Song, H., Saitô, K., Nozato, K., Latchney, L. R., Leonard, B. T., Chung, M. M., Williams, D. R., & Rossi, E. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24677 · Cited by 71
Structural brain MRI studies in eye diseases: are they clinically relevant? A review of current findings
Prins, D., Hanekamp, S., & Cornelissen, F. W. (2015) · Acta Ophthalmologica · doi:10.1111/aos.12825 · Cited by 74
Potential Sources and Roles of Adaptive Immunity in Age-Related Macular Degeneration: Shall We Rename AMD into Autoimmune Macular Disease?
Camelo, S. (2014) · Autoimmune Diseases · doi:10.1155/2014/532487 · Cited by 72
SUBFOVEAL CHOROIDAL THICKNESS IN RETINAL ANGIOMATOUS PROLIFERATION
Yamazaki, T., Koizumi, H., Yamagishi, T., & Kinoshita, S. (2014) · Retina · doi:10.1097/iae.0000000000000086 · Cited by 68
Serous pigment epithelial detachment in age-related macular degeneration: comparison of different treatments
Lommatzsch, A. P., Heimes, B., Gutfleisch, M., Spital, G., Zeimer, M. B., & Pauleikhoff, D. (2009) · Eye · doi:10.1038/eye.2008.425 · Cited by 67
Concordance of Disease Progression in Bilateral Geographic Atrophy Due to AMD
Fleckenstein, M., Adrion, C., Schmitz-Valckenberg, S., Göbel, A. P., Bindewald-Wittich, A., Scholl, H. P. N., Mansmann, U., & Holz, F. G. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3547 · Cited by 60
PRIMARY INTRAVITREAL BEVACIZUMAB FOR SUBFOVEAL CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION
Arévalo, J. F., Fromow-Guerra, J., Sánchez, J. G., Maia, M., Berrocal, M. H., Wu, L., Saravia, M., & Costa, R. A. (2008) · Retina · doi:10.1097/iae.0b013e3181884ff4 · Cited by 60
Environmental cadmium and lead exposures and age-related macular degeneration in U.S. adults: The National Health and Nutrition Examination Survey 2005 to 2008
Wu, E. W., Schaumberg, D. A., & Park, S. K. (2014) · Environmental Research · doi:10.1016/j.envres.2014.05.023 · Cited by 58
Functional loss in early age-related maculopathy: the ischaemia postreceptoral hypothesis
Feigl, B., Brown, B. H., Lovie‐Kitchin, J. E., & Swann, P. (2006) · Eye · doi:10.1038/sj.eye.6702389 · Cited by 55
Role of Optical Coherence Tomography Imaging in Predicting Progression of Age-Related Macular Disease: A Survey
Elsharkawy, M., Elrazzaz, M., Ghazal, M. A., Alhalabi, M. T., Soliman, A., Mahmoud, A. H., El-Daydamony, E., Atwan, A., Thanos, A., Sandhu, H. S., et al. (2021) · Diagnostics · doi:10.3390/diagnostics11122313 · Cited by 58
Age-Related Macular Degeneration: An Exponentially Emerging Imminent Threat of Visual Impairment and Irreversible Blindness
Chaudhuri, M., Hassan, Y., Vemana, P. P. S. B., Pattanashetty, M. S. B., Abdin, Z. U., & Siddiqui, H. F. (2023) · Cureus · doi:10.7759/cureus.39624 · Cited by 62
Subclinical Atherosclerotic Cardiovascular Disease and Early Age-Related Macular Degeneration in a Multiracial Cohort
Klein, R. (2007) · Archives of Ophthalmology · doi:10.1001/archopht.125.4.534 · Cited by 53
Anti-inflammatory and Antiangiogenic Effects of Nanoparticle-Mediated Delivery of a Natural Angiogenic Inhibitor
Jin, J., Zhou, K., Park, K., Hu, Y., Xu, X., Zheng, Z. J., Tyagi, P., Kompella, U. B., & Ma, J. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6229 · Cited by 48
Prevalence, Natural Course, and Prognostic Role of Refractile Drusen in Age-Related Macular Degeneration
Oishi, A., Thiele, S., Nadal, J., Oishi, M., Fleckenstein, M., Schmid, M. C., Holz, F. G., & Schmitz-Valckenberg, S. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.16-20781 · Cited by 47
RESPONSE OF PIGMENT EPITHELIAL DETACHMENTS TO INTRAVITREAL AFLIBERCEPT AMONG PATIENTS WITH TREATMENT-RESISTANT NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
Broadhead, G., Hong, T., Zhu, M., Li, H., Schlub, T. E., Wijeyakumar, W., & Chang, A. (2015) · Retina · doi:10.1097/iae.0000000000000409 · Cited by 46
Optical coherence tomography angiography in age-related macular degeneration: The game changer
Lupidi, M., Cerquaglia, A., Chhablani, J. K., Fiore, T., Singh, S. R., Piccolino, F. C., Corbucci, R., Coscas, F., COSCAS, G. J., & Cagini, C. (2018) · European Journal of Ophthalmology · doi:10.1177/1120672118766807 · Cited by 47
What determines the switch between atrophic and neovascular forms ofage related macular degeneration? - the role of BMP4 induced senescence
Zhu, D., Deng, X., Xu, J., & Hinton, D. R. (2009) · Aging · doi:10.18632/aging.100078 · Cited by 45
Intravitreales Bevacizumab bei der neovaskulären altersabhängigen Makuladegeneration
Ladewig, M. S., Ziemssen, F., Jaissle, G. B., Helb, H. –., Scholl, H. P. N., Eter, N., Bartz-Schmidt, K. U., & Holz, F. G. (2006) · Der Ophthalmologe · doi:10.1007/s00347-006-1352-5 · Cited by 45
Drusen maculopathy: a risk factor for visual deterioration
Algvere, P. V., Kvanta, A., & Seregard, S. (2016) · Acta Ophthalmologica · doi:10.1111/aos.13011 · Cited by 44
Phillyrin Mitigates Apoptosis and Oxidative Stress in Hydrogen Peroxide-Treated RPE Cells through Activation of the Nrf2 Signaling Pathway
Du, Y., You, L., Ni, B., Sai, N., Wang, W., Sun, M., Xu, R., Yao, Y., Zhang, Z., Qu, C., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2684672 · Cited by 42
Effect of intravitreal ranibizumab in avascular pigment epithelial detachment
Ritter, M., Bolz, M., Sacu, S., Deák, G. G., Kiss, C., Prünte, C. F., & Schmidt-Erfurth, U. M. (2009) · Eye · doi:10.1038/eye.2009.265 · Cited by 42
Intravitreal Bevacizumab for Subfoveal Choroidal Neovascularization in Age-Related Macular Degeneration at Twenty-four Months: The Pan-American Collaborative Retina Study
Arévalo, J. F., Sánchez, J. G., Wu, L., Berrocal, M. H., Alezzandrini, A., Restrepo, N. A., Maia, M., Farah, M. E., Brito, M., Díaz-Llopis, M., et al. (2010) · Ophthalmology · doi:10.1016/j.ophtha.2010.01.056 · Cited by 40
Dense deposit disease: new insights
Walker, P. D. (2007) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3280bdc0f4 · Cited by 40
The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis
Zhang, R., Liu, Z., Zhang, H., Zhang, Y., & Lin, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146808 · Cited by 40
Surface-Based Analyses of Anatomical Properties of the Visual Cortex in Macular Degeneration
Prins, D., Plank, T., Baseler, H. A., Gouws, A. D., Beer, A., Morland, A. B., Greenlee, M. W., & Cornelissen, F. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0146684 · Cited by 41
Occipital Proton Magnetic Resonance Spectroscopy (1H-MRS) Reveals Normal Metabolite Concentrations in Retinal Visual Field Defects
Boucard, C. C., Hoogduin, J. M., van der Grond, J., & Cornelissen, F. W. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000222 · Cited by 38
Alcohol linked to enhanced angiogenesis in rat model of choroidal neovascularization
Bora, P. S., Kaliappan, S., Xu, Q., Kumar, S., Wang, Y., Kaplan, H. J., & Bora, N. S. (2006) · FEBS Journal · doi:10.1111/j.1742-4658.2006.05163.x · Cited by 39
Choroidal circulatory disturbances associated with retinal angiomatous proliferation on indocyanine green angiography
Koizumi, H., Iida, T., Saito, M., Nagayama, D., & Maruko, I. (2007) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-007-0705-3 · Cited by 37
AAV-Mediated Gene Therapy for Retinal Disorders in Large Animal Models
Stieger, K., Lhériteau, E., Moullier, P., & Rolling, F. (2009) · ILAR Journal · doi:10.1093/ilar.50.2.206 · Cited by 38
Sorafenib prevents human retinal pigment epithelium cells from light-induced overexpression of VEGF, PDGF and PlGF
Kernt, M., Neubauer, A. S., Liegl, R. G.-H., Hirneiß, C., Alge, C. S., Wolf, A., ULBIG, M. W., & Kampik, A. (2010) · British Journal of Ophthalmology · doi:10.1136/bjo.2010.182162 · Cited by 37
Ranibizumab for retinal angiomatous proliferation in age-related macular degeneration
Atmani, K., Voigt, M., Tien, V. L., Querques, G., COSCAS, G. J., Soubrane, G., & Souied, E. H. (2010) · Eye · doi:10.1038/eye.2010.9 · Cited by 35
Combined intravitreal bevacizumab and photodynamic therapy for neovascular age-related macular degeneration
Ladewig, M. S., Karl, S. E., Hamelmann, V., Helb, H. –., Scholl, H. P. N., Holz, F. G., & Eter, N. (2007) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-007-0654-x · Cited by 34
Retinal pigment epithelium cell damage by A2-E and its photo-derivatives.
Hammer, M., Richter, S., Guehrs, K.-H., & Schweitzer, D. (2006) · PubMed · Cited by 33
Mechanisms of protection of retinal pigment epithelial cells from oxidant injury by humanin and other mitochondrial-derived peptides: Implications for age-related macular degeneration
Sreekumar, P. G., & Kannan, R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101663 · Cited by 32
Photobiology of lipofuscin granules in the retinal pigment epithelium cells of the eye: norm, pathology, age
Feldman, T. B., Dontsov, A. E., Yakovleva, M. A., & Оstrovsky, М. А. (2022) · Biophysical Reviews · doi:10.1007/s12551-022-00989-9 · Cited by 30
New Components of ‘Basal Laminar Deposits’ in Age-Related Macular Degeneration
Reale, E., Groos, S., Eckardt, U., Eckardt, C., & Luciano, L. (2008) · Cells Tissues Organs · doi:10.1159/000187632 · Cited by 29
Beyond AREDS Formulations, What Is Next for Intermediate Age-Related Macular Degeneration (iAMD) Treatment? Potential Benefits of Antioxidant and Anti-inflammatory Apocarotenoids as Neuroprotectors
Camelo, S., Latil, M., Veillet, S., Dilda, P. J., & Lafont, R. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/4984927 · Cited by 30
Genotoxic Effects of Carotenoid Breakdown Products in Human Retinal Pigment Epithelial Cells
Kalariya, N. M., Ramana, K. V., Srivastava, S. K., & van Kuijk, F. J. G. M. (2009) · Current Eye Research · doi:10.1080/02713680903046855 · Cited by 27
Retinal Pigment Epithelium Pigment Granules: Norms, Age Relations and Pathology
Dontsov, A. E., & Оstrovsky, М. А. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073609 · Cited by 28
ORAL ADMINISTRATION OF LUMIRACOXIB REDUCES CHOROIDAL NEOVASCULAR MEMBRANE DEVELOPMENT IN THE RAT LASER-TRAUMA MODEL
Hu, W., Criswell, M. H., Ottlecz, A., Cornell, T. L., Danis, R. P., Lambrou, G. N., & Ciulla, T. A. (2005) · Retina · doi:10.1097/00006982-200512000-00015 · Cited by 27
Reliability of Retinal Pathology Quantification in Age-Related Macular Degeneration: Implications for Clinical Trials and Machine Learning Applications
Müller, P. L., Liefers, B. J., Treis, T., Rodrigues, F. G., Olvera‐Barrios, A., Paul, B., Dhingra, N., Lotery, A. J., Bailey, C., Taylor, P. M., et al. (2021) · Translational Vision Science & Technology · doi:10.1167/tvst.10.3.4 · Cited by 26
Transplantation von retinalem Pigmentepithel (RPE) nach CNV-Exzision bei altersabhängiger Makuladegeneration
Bindewald-Wittich, A., Roth, F., van Meurs, J., & Holz, F. G. (2004) · Der Ophthalmologe · doi:10.1007/s00347-004-1077-2 · Cited by 26
Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein b-100 genes
Sallo, F. B., Bereczki, E., Csont, T., Luthert, P. J., Munro, P., Ferdinandy, P., Sántha, M., & Lengyel, I. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.03.006 · Cited by 25
Lysosomal stress and lipid peroxidation products induce VEGF-121 and VEGF-165 expression in ARPE-19 cells
Bergmann, M., Holz, F. G., & Kopitz, J. (2011) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-011-1682-0 · Cited by 25
Die Rolle des retinalen Pigmentepithels im Rahmen visueller Funktionen
Strauß, O. (2009) · Der Ophthalmologe · doi:10.1007/s00347-008-1869-x · Cited by 26
Ocular hazards of blue-light therapy in dermatology
Walker, D. P., Vollmer-Snarr, H. R., & Eberting, C. L. D. (2011) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2010.11.040 · Cited by 24
Central Retinal Findings in Bothnia Dystrophy Caused by RLBP1 Sequence Variation
Burstedt, M. S. I. (2010) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2010.167 · Cited by 24
Light-induced release of A2E photooxidation toxic products from lipofuscin granules of human retinal pigment epithelium
Dontsov, A. E., Sakina, N. L., Golubkov, A. M., & Оstrovsky, М. А. (2009) · Doklady Biochemistry and Biophysics · doi:10.1134/s1607672909020112 · Cited by 24
Beta-adrenergic receptor regulation of growth factor protein levels in human choroidal endothelial cells
Steinle, J. J., Cappocia, F. C., & Jiang, Y. (2008) · Growth Factors · doi:10.1080/08977190802442070 · Cited by 22

Authors: Holz, F. G., Pauleikhoff, D., Klein, R., & Bird, A. C.
Affiliations: Heidelberg University (DE)
St. Franziskus Hospital (DE)
University of Wisconsin–Madison (US)
University of London (GB)
Corresponding author: Bird, Alan C.
ORCID: Holz, Frank G.
Pauleikhoff, Daniel
Klein, Ronald
Bird, Alan C.
Venue: American Journal of Ophthalmology
Publisher: Elsevier BV
Published: 2004-03
Volume: 137
Issue: 3
Pages: 504-510
ISSN: 0002-9394 (ISSN-L)
DOI: 10.1016/j.ajo.2003.11.026
OpenAlex: W2168896662
Cited by: 203
References: 53
Citations by year: 2025: 2 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 8 · 2015: 4 · 2014: 9 · 2013: 11 · 2012: 13
FWCI: 2.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Ophthalmology (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Health Sciences › Medicine › Ophthalmology › Retinal and Macular Surgery
Keywords: age-related macular degeneration, choroidal neovascularization, retinal pigment epithelium, retinal angiomatous proliferation, pigment epithelial detachment, Bruch's membrane, geographic atrophy, lipofuscin accumulation, growth factors, pathogenesis
MeSH terms: Humans, Macular Degeneration, Vision Disorders

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pathogenesis of lesions in late age-related macular disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks