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Cited by 42Retinal Diseases and TreatmentsRetinal and Macular SurgeryOcular Diseases and Behçet’s Syndrome

Prophylactic laser treatment hastens choroidal neovascularization in unilateral age-related maculopathy: final results of the drusen laser study

Owens, Sarah L., Bunce, Catey, Brannon, Alan J., Xing, Wen, Chisholm, Iain H., Gross, Mirjam, Guymer, Robyn H., Holz, Frank G. +1 more·2006·American Journal of Ophthalmology
DOI 10.1016/j.ajo.2005.08.019
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Abstract

Purpose The Drusen Laser Study evaluated macular laser to prevent choroidal neovascularization (CNV) and vision loss in high-risk age-related maculopathy (ARM).Design Prospective, interventional, randomized, controlled clinical trial in five hospital centers.Methods Patients in the unilateral group had neovascular ARM and drusen in the study eye. Study eyes were randomized to laser-treated or no-laser groups. For patients in the bilateral drusen group, eyes were randomized to right eye, laser or no laser; and left eye, alternative. Laser treatment comprised 12 argon spots. Outcome was best-corrected visual acuity and CNV signs, which were monitored for 3 years.Results In the unilateral group, vision loss occurred in 21 (28.8%) of 73 patients in laser vs 13 (19.7%) of 66 no-laser patients (P=.214). Incidence of CNV was 27 (29.7%) of 91 in laser vs 15 (17.65%) of 85 no-laser patients (P=.061). CNV onset was approximately 6 months earlier in laser-treated compared with no-laser patients (P=.05). In the bilateral group, vision loss occurred in six (8.3%) of 72 laser-treated vs 10 (13.9%) of 72 fellow eyes (P=.3877). CNV incidence was 12 (11.6%) of 103 in laser-treated vs seven (6.8%) of 103 fellow eyes (P=.225). There was no difference in onset of CNV.Conclusions Results do not support prophylactic laser of the fellow eye of patients with neovascular ARM. Its role in patients with bilateral drusen remains unclear.

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  • Laser treatment did seem to delay the development of choroidal neovascularisation by 6 months in studies that included patients with unilateral advanced age-related macular degeneration.

    “Laser treatment did seem to delay the development of choroidal neovascularisation by 6 months in studies that included patients with unilateral advanced age-related macular degeneration.157,158”

    From Age-related macular degeneration (2008) · cites this paper as [157]

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Authors
Owens, S. L., Bunce, C., Brannon, A. J., Xing, W., Chisholm, I. H., Gross, M., Guymer, R. H., Holz, F. G., & Bird, A. C.
Affiliations
  • Moorfields Eye Hospital NHS Foundation Trust (GB)
  • Moorfields Eye Hospital (GB)
  • The University of Melbourne (AU)
  • Heidelberg University (DE)
Corresponding author
Owens, Sarah L.
ORCID
Venue
American Journal of Ophthalmology
Publisher
Elsevier BV
Published
2006-02
Volume
141
Issue
2
Pages
276-281
ISSN
0002-9394 (ISSN-L)
DOI
10.1016/j.ajo.2005.08.019
OpenAlex
W1983972989
Cited by
42
References
20
Citations by year
2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 3
FWCI
4.27
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
choroidal neovascularization, age-related maculopathy, drusen, argon laser, blindness prevention, best-corrected visual acuity, fellow eye
MeSH terms
Aged, Aged, 80 and over, Female, Humans, Functional Laterality, Macular Degeneration, Male, Middle Aged, Prospective Studies, Visual Acuity, Retinal Drusen, Incidence, Laser Coagulation, Choroidal Neovascularization

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