Effect of patient age on increasing morbidity and mortality following urogynecologic surgery
Abstract
Objective The purpose of this study was to estimate the effect of age on the risk of in-hospital mortality and morbidity following urogynecologic surgery and to compare risks associated with obliterative versus reconstructive procedures for prolapse in elderly women.Study design We conducted a retrospective cohort study utilizing data from 1998 to 2002 from the Nationwide Inpatient Sample. Multivariable logistic regression was performed to obtain odds ratios estimating the effect of age on risk of death and complications, adjusting for comorbidities and demographic factors.Results There were 264,340 women in our study population. Increasing age was associated with higher mortality risks per 1000 women (< 60 years, 0.1; 60-69 years, 0.5; 70-79 years, 0.9; > or = 80 years, 2.8; P < .01) and higher complication risks per 1000 women (< 60 years, 140; 60-69 years, 130; 70-79 years, 160; > or = 80 years, 200; P < .01). Using multivariable logistic regression, increasing age was associated with an increased risk of death (60-69 years, odds ratio [OR] 3.4 [95% CI 1.7-6.9]; 70-79 years, OR 4.9 [95% CI 2.2-10.9]; > or = 80 years, OR 13.6 [95% CI 5.9-31.4]), compared with women < 60 years. The risk of peri-operative complications was also higher in elderly women 80 years of age and older (OR 1.4 [95% CI 1.3-1.5]) compared with younger women. Elderly women 80 years and over who underwent obliterative procedures had a lower risk of complication compared with those who underwent reconstructive procedures for prolapse (17.0% vs 24.7%, P < .01).Conclusion Although the absolute risk of death is low, elderly women have a higher risk of mortality and morbidity following urogynecologic surgery.
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Many studies addressing perioperative outcomes and frailty, including in gynecologic surgery, are retrospective in nature or database driven.
“Many studies--including those looking at gynecologic surgery--addressing perioperative outcomes and frailty are retrospective in nature or database driven leaving opportunity for further understanding the impact of frailty on gynecologic surgery outcomes in prospective surgical trials.7–16”
Coexisting comorbidities can lead to worse treatment outcomes.
“Coexisting co-morbidities, also common in women with urinary incontinence, can lead to worse treatment outcomes (19–21)”
From Urinary incontinence and disability in community-dwelling women: A cross-sectional study: Urinary Incontinence and Disability in Ambulatory Women (2015) · cites this paper as [21]
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Self-citation
- Authors
- Sung, V. W., Weitzen, S., Sokol, E. R., Rardin, C. R., & Myers, D. L.
- Affiliations
- Brown University (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2006-05
- Volume
- 194
- Issue
- 5
- Pages
- 1411-1417
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2059926618
- Cited by
- 177
- References
- 25
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 9 · 2023: 11 · 2022: 3 · 2021: 11 · 2020: 16 · 2019: 13 · 2018: 8 · 2017: 16 · 2016: 15 · 2015: 10 · 2014: 12 · 2013: 4 · 2012: 5
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Child Health and Human Development
- Topics
- Health Sciences › Medicine › Rheumatology › Pelvic floor disorders treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac, Anesthesia and Surgical Outcomes
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- patient age, older women, urogynecologic surgery, postoperative mortality, postoperative complications, pelvic organ prolapse, surgical risk
- MeSH terms
- Aged, Aged, 80 and over, Aging, Female, Humans, Intraoperative Complications, Middle Aged, Postoperative Complications, Retrospective Studies, Urogenital Surgical Procedures, Uterine Prolapse, Cohort Studies, Logistic Models, Risk Assessment, Plastic Surgery Procedures
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